Search Results - "Krętowski, Rafał"

Novel Dual PI3K/mTOR Inhibitor, Apitolisib (GDC-0980), Inhibits Growth and Induces Apoptosis in Human Glioblastoma Cells by Omeljaniuk, Wioleta Justyna, Krętowski, Rafał, Ratajczak-Wrona, Wioletta, Jabłońska, Ewa, Cechowska-Pasko, Marzanna

“…Deregulated PI3K/AKT/mTOR signalling commonly exists in glioblastoma, making this axis an attractive target for therapeutic manipulation. Given that activation…”
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Phenylbutyrate—a pan-HDAC inhibitor—suppresses proliferation of glioblastoma LN-229 cell line by Kusaczuk, Magdalena, Krętowski, Rafał, Bartoszewicz, Marek, Cechowska-Pasko, Marzanna

“…Phenylbutyrate (PBA) is a histone deacetylase inhibitor known for inducing differentiation, cell cycle arrest, and apoptosis in various cancer cells. However,…”
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The Influence of Mesotrione on Human Colorectal Adenocarcinoma Cells and Possibility of Its Toxicity Mitigation by Cichoric Acid by Jabłońska-Trypuć, Agata, Wydro, Urszula, Wołejko, Elżbieta, Kalinowska, Monika, Świderski, Grzegorz, Krętowski, Rafał, Naumowicz, Monika, Kondzior, Paweł, Cechowska-Pasko, Marzanna, Lewandowski, Włodzimierz

“…Mesotrione, as a widely used herbicide, is present in the environment in detectable amounts, causing serious damage. Here, we aimed to investigate the effect…”
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Selected Fungicides as Potential EDC Estrogenic Micropollutants in the Environment by Jabłońska-Trypuć, Agata, Wydro, Urszula, Wołejko, Elżbieta, Makuła, Marcin, Krętowski, Rafał, Naumowicz, Monika, Sokołowska, Gabriela, Serra-Majem, Lluis, Cechowska-Pasko, Marzanna, Łozowicka, Bożena, Kaczyński, Piotr, Wiater, Józefa

“…An increasing level of pesticide exposition is being observed as a result of the consumption of large amounts of fruits, vegetables and grain products, which…”
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Possible Mechanisms of the Prevention of Doxorubicin Toxicity by Cichoric Acid-Antioxidant Nutrient by Jabłońska-Trypuć, Agata, Krętowski, Rafał, Kalinowska, Monika, Świderski, Grzegorz, Cechowska-Pasko, Marzanna, Lewandowski, Włodzimierz

“…Skin is the largest organ in the human body, and which protects organism against unfavorable external factors e.g., chemicals, environment pollutants,…”
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Glucose deficiency reduces collagen synthesis in breast cancer MCF7 cells by Cechowska-Pasko, Marzanna, Krętowski, Rafał, Bańkowski, Edward

“…We decided to study the effect of glucose deprivation on collagen metabolism in MCF7 cells. The incorporation of [3H]‐proline into collagenase‐sensitive and…”
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The Reduced Graphene Oxide (rGO) Induces Apoptosis, Autophagy and Cell Cycle Arrest in Breast Cancer Cells by Krętowski, Rafał, Cechowska-Pasko, Marzanna

“…Reduced graphene oxide (rGO) has already been reported as a potential cytostatic agent in various cancers. However, the mechanisms underlying rGO's…”
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A Preliminary Study of the Effect of Quercetin on Cytotoxicity, Apoptosis, and Stress Responses in Glioblastoma Cell Lines by Kusaczuk, Magdalena, Krętowski, Rafał, Naumowicz, Monika, Stypułkowska, Anna, Cechowska-Pasko, Marzanna

“…A growing body of evidence indicates that dietary polyphenols show protective effects against various cancers. However, little is known yet about their…”
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Marizomib (Salinosporamide A) Promotes Apoptosis in A375 and G361 Melanoma Cancer Cells by Piskorz, Wiktoria Monika, Krętowski, Rafał, Cechowska-Pasko, Marzanna

“…Malignant melanoma-a tumor originating from melanocytes-is characterized by dynamic growth and frequent metastases in the early stage of development. Current…”
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Newly Synthesized Doxorubicin Complexes with Selected Metals-Synthesis, Structure and Anti-Breast Cancer Activity by Jabłońska-Trypuć, Agata, Świderski, Grzegorz, Krętowski, Rafał, Lewandowski, Włodzimierz

“…Doxorubicin (DOX) is very effective chemotherapeutic agent, however it has several major drawbacks. Therefore the motivation for developing novel drug…”
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Corrigendum to “The modulating effect of lipid bilayer/p-coumaric acid interactions on electrical properties of model lipid membranes and human glioblastoma cells” [Bioorg. Chem. 92 (2019) 103242] by Naumowicz, Monika, Kusaczuk, Magdalena, Kruszewski, Marcin Andrzej, Gál, Miroslav, Krętowski, Rafał, Cechowska-Pasko, Marzanna, Kotyńska, Joanna

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The Preliminary Study on the Proapoptotic Effect of Reduced Graphene Oxide in Breast Cancer Cell Lines by Krętowski, Rafał, Jabłońska-Trypuć, Agata, Cechowska-Pasko, Marzanna

“…Breast cancer is the most common cancer diagnosed in women, however traditional therapies have several side effects. This has led to an urgent need to explore…”
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The Effect of Silica Nanoparticles (SiNPs) on Cytotoxicity, Induction of Oxidative Stress and Apoptosis in Breast Cancer Cell Lines by Krętowski, Rafał, Jabłońska-Trypuć, Agata, Cechowska-Pasko, Marzanna

“…Breast cancer is one of the most common cancers in women. Silica nanoparticles (SiNPs) belong to the group of often-used nanoparticles in biomedical…”
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The Proteasome Inhibitor Marizomib Evokes Endoplasmic Reticulum Stress and Promotes Apoptosis in Human Glioblastoma Cells by Kusaczuk, Magdalena, Tyszka, Natalia, Krętowski, Rafał, Cechowska-Pasko, Marzanna

“…Proteasomes play an important role in the physiology of cancer cells, and inhibition of their activity may be used as a promising therapeutic strategy against…”
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The Pro-Apoptotic Effect of Silica Nanoparticles Depends on Their Size and Dose, as Well as the Type of Glioblastoma Cells by Krętowski, Rafał, Kusaczuk, Magdalena, Naumowicz, Monika, Cechowska-Pasko, Marzanna

“…Despite intensive investigations, nanoparticle-induced cellular damage is an important problem that has not been fully elucidated yet. Here, we report that…”
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The Synergistic Effect of Reduced Graphene Oxide and Proteasome Inhibitor in the Induction of Apoptosis through Oxidative Stress in Breast Cancer Cell Lines by Krętowski, Rafał, Szynaka, Beata, Jabłońska-Trypuć, Agata, Kiełtyka-Dadasiewicz, Anna, Cechowska-Pasko, Marzanna

“…Reduced graphene oxide (rGO) and a proteasome inhibitor (MG-132) are some of the most commonly used compounds in various biomedical applications. However, the…”
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Molecular and Cellular Effects of Chemical Chaperone-TUDCA on ER-Stressed NHAC-kn Human Articular Chondrocytes Cultured in Normoxic and Hypoxic Conditions by Kusaczuk, Magdalena, Naumowicz, Monika, Krętowski, Rafał, Cukierman, Bartosz, Cechowska-Pasko, Marzanna

“…Osteoarthritis (OA) is considered one of the most common arthritic diseases characterized by progressive degradation and abnormal remodeling of articular…”
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Silica nanoparticle-induced oxidative stress and mitochondrial damage is followed by activation of intrinsic apoptosis pathway in glioblastoma cells by Kusaczuk, Magdalena, Krętowski, Rafał, Naumowicz, Monika, Stypułkowska, Anna, Cechowska-Pasko, Marzanna

“…Recently, the focus of oncological research has been on the optimization of therapeutic strategies targeted at malignant diseases. Nanomedicine utilizing…”
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Traumatic acid toxicity mechanisms in human breast cancer MCF-7 cells by Jabłońska-Trypuć, Agata, Krętowski, Rafał, Wołejko, Elżbieta, Wydro, Urszula, Butarewicz, Andrzej

“…Traumatic acid (TA) – an oxidative derivative of unsaturated fatty acids, belongs to the cytokinins category – a group of plant hormones, which play an…”
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Anethole prevents hydrogen peroxide-induced apoptosis and collagen metabolism alterations in human skin fibroblasts by Galicka, Anna, Krętowski, Rafał, Nazaruk, Jolanta, Cechowska-Pasko, Marzanna

“…The collagen metabolism alterations triggered by reactive oxygen species are involved in the development of various connective tissue diseases and skin aging…”
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