Search Results - "Krüger, Dennis"

Active Site Hydrophobicity and the Convergent Evolution of Paraoxonase Activity in Structurally Divergent Enzymes: The Case of Serum Paraoxonase 1 by Blaha-Nelson, David, Krüger, Dennis M, Szeler, Klaudia, Ben-David, Moshe, Kamerlin, Shina Caroline Lynn

“…Serum paraoxonase 1 (PON1) is a native lactonase capable of promiscuously hydrolyzing a broad range of substrates, including organophosphates, esters, and…”
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Protein-RNA interactions: structural characteristics and hotspot amino acids by Krüger, Dennis M, Neubacher, Saskia, Grossmann, Tom N

“…Structural information about protein-RNA complexes supports the understanding of crucial recognition processes in the cell, and it can allow the development of…”
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Structure-Based Design of Non-natural Macrocyclic Peptides That Inhibit Protein–Protein Interactions by Krüger, Dennis M, Glas, Adrian, Bier, David, Pospiech, Nicole, Wallraven, Kerstin, Dietrich, Laura, Ottmann, Christian, Koch, Oliver, Hennig, Sven, Grossmann, Tom N

“…Macrocyclic peptides can interfere with challenging biomolecular targets including protein–protein interactions. Whereas there are various approaches that…”
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Long Time-Scale Atomistic Simulations of the Structure and Dynamics of Transcription Factor-DNA Recognition by Liao, Qinghua, Lüking, Malin, Krüger, Dennis M, Deindl, Sebastian, Elf, Johan, Kasson, Peter M, Lynn Kamerlin, Shina Caroline

“…Recent years have witnessed an explosion of interest in computational studies of DNA binding proteins, including both coarse-grained and atomistic simulations…”
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Highly Efficient Thermal and Light-Induced Spin-State Switching of an Fe(II) Complex in Direct Contact with a Solid Surface by Bernien, Matthias, Naggert, Holger, Arruda, Lucas M, Kipgen, Lalminthang, Nickel, Fabian, Miguel, Jorge, Hermanns, Christian F, Krüger, Alex, Krüger, Dennis, Schierle, Enrico, Weschke, Eugen, Tuczek, Felix, Kuch, Wolfgang

“…Spin crossover (SCO) complexes possess a bistable spin state that reacts sensitively to changes in temperature or excitation with light. These effects have…”
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The Apeli: An Affordable, Low-Emission and Fuel-Flexible Tier 4 Advanced Biomass Cookstove by Krüger, Dennis, Mutlu, Özge

“…Based on the decision of representatives from the West African region and feedback from locals in Togo, an advanced continuous-feed, forced-draft, biomass…”
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Correction to “Micelle Maker: An Online Tool for Generating Equilibrated Micelles as Direct Input for Molecular Dynamics Simulations” by Krüger, Dennis M., Kamerlin, Shina C. L.

“…[This corrects the article DOI: 10.1021/acsomega.7b00820.]…”
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NMSim web server: integrated approach for normal mode-based geometric simulations of biologically relevant conformational transitions in proteins by Krüger, Dennis M, Ahmed, Aqeel, Gohlke, Holger

“…The NMSim web server implements a three-step approach for multiscale modeling of protein conformational changes. First, the protein structure is coarse-grained…”
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CNA web server: rigidity theory-based thermal unfolding simulations of proteins for linking structure, (thermo-)stability, and function by Krüger, Dennis M, Rathi, Prakash Chandra, Pfleger, Christopher, Gohlke, Holger

“…The Constraint Network Analysis (CNA) web server provides a user-friendly interface to the CNA approach developed in our laboratory for linking results from…”
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PRDM16-DT is a novel lncRNA that regulates astrocyte function in Alzheimer’s disease by Schröder, Sophie, Fuchs, Ulrike, Gisa, Verena, Pena, Tonatiuh, Krüger, Dennis M., Hempel, Nina, Burkhardt, Susanne, Salinas, Gabriela, Schütz, Anna-Lena, Delalle, Ivana, Sananbenesi, Farahnaz, Fischer, Andre

“…Astrocytes provide crucial support for neurons, contributing to synaptogenesis, synaptic maintenance, and neurotransmitter recycling. Under pathological…”
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A Single-Cell Transcriptomic Analysis of the Mouse Hippocampus After Voluntary Exercise by Methi, Aditi, Islam, Md Rezaul, Kaurani, Lalit, Sakib, M Sadman, Krüger, Dennis M., Pena, Tonatiuh, Burkhardt, Susanne, Liebetanz, David, Fischer, André

“…Exercise has been recognized as a beneficial factor for cognitive health, particularly in relation to the hippocampus, a vital brain region responsible for…”
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How Good Are State-of-the-Art Docking Tools in Predicting Ligand Binding Modes in Protein–Protein Interfaces? by Krüger, Dennis M, Jessen, Gisela, Gohlke, Holger

“…Protein–protein interfaces (PPIs) are an important class of drug targets. We report on the first large-scale validation study on docking into PPIs…”
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Demonstration of a Top-Lit Updraft Based Pyrolytic Burner with Low Emission Operation and Automatic Process Control by Krüger, Dennis, Mutlu, Özge Çepelioğullar

“…In this study, a small-scale (4.7 kWfuel) biomass burner based on “top-lit updraft” (TLUD) technology with automatic process control was developed for process…”
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Translocation of an Intracellular Protein via Peptide-Directed Ligation by Stiller, Christiane, Krüger, Dennis M, Brauckhoff, Nicolas, Schmidt, Marcel, Janning, Petra, Salamon, Hazem, Grossmann, Tom N

“…Ligand-directed reactions allow chemical transformations at very low reactant concentrations and can thus provide access to efficient approaches for the…”
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Amyloid‑β Peptide Interactions with Amphiphilic Surfactants: Electrostatic and Hydrophobic Effects by Österlund, Nicklas, Kulkarni, Yashraj S, Misiaszek, Agata D, Wallin, Cecilia, Krüger, Dennis M, Liao, Qinghua, Mashayekhy Rad, Farshid, Jarvet, Jüri, Strodel, Birgit, Wärmländer, Sebastian K. T. S, Ilag, Leopold L, Kamerlin, Shina C. L, Gräslund, Astrid

“…The amphiphilic nature of the amyloid-β (Aβ) peptide associated with Alzheimer’s disease facilitates various interactions with biomolecules such as lipids and…”
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Highly Efficient and Bidirectional Photochromism of Spirooxazine on Au(111) by Nickel, Fabian, Bernien, Matthias, Krüger, Dennis, Miguel, Jorge, Britton, Andrew J, Arruda, Lucas M, Kipgen, Lalminthang, Kuch, Wolfgang

“…Controlling molecules in direct contact with surfaces is central to molecular electronics. Photochromic molecules immobilized and contacted by a surface…”
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Regulation of Zbp1 by miR-99b-5p in microglia controls the development of schizophrenia-like symptoms in mice by Kaurani, Lalit, Islam, Md Rezaul, Heilbronner, Urs, Krüger, Dennis M, Zhou, Jiayin, Methi, Aditi, Strauss, Judith, Pradhan, Ranjit, Schröder, Sophie, Burkhardt, Susanne, Schuetz, Anna-Lena, Pena, Tonatiuh, Erlebach, Lena, Bühler, Anika, Budde, Monika, Senner, Fanny, Kohshour, Mojtaba Oraki, Schulte, Eva C, Schmauß, Max, Reininghaus, Eva Z, Juckel, Georg, Kronenberg-Versteeg, Deborah, Delalle, Ivana, Odoardi, Francesca, Flügel, Alexander, Schulze, Thomas G, Falkai, Peter, Sananbenesi, Farahnaz, Fischer, Andre

“…Current approaches to the treatment of schizophrenia have mainly focused on the protein-coding part of the genome; in this context, the roles of microRNAs have…”
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Blood‐derived microRNAs are related to cognitive domains in the general population by Melas, Konstantinos, Talevi, Valentina, Imtiaz, Mohammed Aslam, Etteldorf, Rika, Estrada, Santiago, Krüger, Dennis M., Pena‐Centeno, Tonatiuh, Aziz, N. Ahmad, Fischer, André, Breteler, Monique M. B.

“…INTRODUCTION Blood‐derived microRNAs (miRNAs) are potential candidates for detecting and preventing subclinical cognitive dysfunction. However, replication of…”
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Exercise as a model to identify microRNAs linked to human cognition: a role for microRNA-409 and microRNA-501 by Goldberg, Maria, Islam, Md Rezaul, Kerimoglu, Cemil, Lancelin, Camille, Gisa, Verena, Burkhardt, Susanne, Krüger, Dennis M., Marquardt, Till, Malchow, Berend, Schmitt, Andrea, Falkai, Peter, Sananbenesi, Farahnaz, Fischer, Andre

“…MicroRNAs have been linked to synaptic plasticity and memory function and are emerging as potential biomarkers and therapeutic targets for cognitive diseases…”
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The plasma miRNAome in ADNI: Signatures to aid the detection of at‐risk individuals by Krüger, Dennis M., Pena‐Centeno, Tonatiuh, Liu, Shiwei, Park, Tamina, Kaurani, Lalit, Pradhan, Ranjit, Huang, Yen‐Ning, Risacher, Shannon L., Burkhardt, Susanne, Schütz, Anna‐Lena, Wan, Yang, Shaw, Leslie M., Brodsky, Alexander S., DeStefano, Anita L., Lin, Honghuang, Schroeder, Robert, Krunic, Andre, Hempel, Nina, Sananbenesi, Farahnaz, Blusztajn, Jan Krzysztof, Saykin, Andrew J., Delalle, Ivana, Nho, Kwangsik, Fischer, Andre

“…INTRODUCTION MicroRNAs are short non‐coding RNAs that control proteostasis at the systems level and are emerging as potential prognostic and diagnostic…”
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