Search Results - "Krötz, Florian"

Reactive Oxygen Species: Players in the Platelet Game by Krötz, Florian, Sohn, Hae-Young, Pohl, Ulrich

“…Platelets participate not only in thrombus formation but also in the regulation of vessel tone, the development of atherosclerosis, angiogenesis, and in…”
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An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 by Koczulla, Rembert, von Degenfeld, Georges, Kupatt, Christian, Krötz, Florian, Zahler, Stefan, Gloe, Torsten, Issbrücker, Katja, Unterberger, Pia, Zaiou, Mohamed, Lebherz, Corinna, Karl, Alexander, Raake, Philip, Pfosser, Achim, Boekstegers, Peter, Welsch, Ulrich, Hiemstra, Pieter S, Vogelmeier, Claus, Gallo, Richard L, Clauss, Matthias, Bals, Robert

“…Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin…”
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SHP-2 regulates growth factor dependent vascular signalling and function by Mannell, Hanna, Krotz, Florian

“…Cellular responses to the environment are mediated by intracellular signalling pathways monitoring several essential cellular processes, such as proliferation,…”
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Atrial Natriuretic Peptide Induces Mitogen-Activated Protein Kinase Phosphatase-1 in Human Endothelial Cells via Rac1 and NAD(P)H Oxidase/Nox2-Activation by Fürst, Robert, Brueckl, Corinna, Kuebler, Wolfgang M, Zahler, Stefan, Krötz, Florian, Görlach, Agnes, Vollmar, Angelika M, Kiemer, Alexandra K

“…The cardiovascular hormone atrial natriuretic peptide (ANP) exerts anti-inflammatory effects on tumor necrosis factor-α–activated endothelial cells by inducing…”
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An angiogenic role for the human peptide antibiotic LL-37/hCAP-18 by Koczulla, Rembert, von Degenfeld, Georges, Kupatt, Christian, Krötz, Florian, Zahler, Stefan, Gloe, Torsten, Issbrücker, Katja, Unterberger, Pia, Zaiou, Mohamed, Lebherz, Corinna, Karl, Alexander, Raake, Philip, Pfosser, Achim, Boekstegers, Peter, Welsch, Ulrich, Hiemstra, Pieter S., Vogelmeier, Claus, Gallo, Richard L., Clauss, Matthias, Bals, Robert

“…Antimicrobial peptides are effector molecules of the innate immune system and contribute to host defense and regulation of inflammation. The human cathelicidin…”
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Prothrombotic effects of tumor necrosis factor alpha in vivo are amplified by the absence of TNF-alpha receptor subtype 1 and require TNF-alpha receptor subtype 2 by Pircher, Joachim, Merkle, Monika, Wörnle, Markus, Ribeiro, Andrea, Czermak, Thomas, Stampnik, Yvonn, Mannell, Hanna, Niemeyer, Markus, Vielhauer, Volker, Krötz, Florian

“…Elevated serum levels of the proinflammatory cytokine tumor necrosis factor alpha (TNFα) correlate with an increased risk for atherothrombotic events and TNFα…”
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Membrane Potential-Dependent Inhibition of Platelet Adhesion to Endothelial Cells by Epoxyeicosatrienoic Acids by Krötz, Florian, Riexinger, Tobias, Buerkle, Martin A, Nithipatikom, Kasem, Gloe, Torsten, Sohn, Hae-Young, Campbell, William B, Pohl, Ulrich

“…OBJECTIVE—Epoxyeicosatrienoic acids (EETs) are potent vasodilators produced by endothelial cells. In many vessels, they are an endothelium-derived…”
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The tyrosine phosphatase SHP-1 regulates hypoxia inducible factor-1α (HIF-1α) protein levels in endothelial cells under hypoxia by Alig, Stefan K, Stampnik, Yvonn, Pircher, Joachim, Rotter, Raffaela, Gaitzsch, Erik, Ribeiro, Andrea, Wörnle, Markus, Krötz, Florian, Mannell, Hanna

“…The tyrosine phosphatase SHP-1 negatively influences endothelial function, such as VEGF signaling and reactive oxygen species (ROS) formation, and has been…”
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Hepatitis C virus induced endothelial inflammatory response depends on the functional expression of TNFα receptor subtype 2 by Pircher, Joachim, Czermak, Thomas, Merkle, Monika, Mannell, Hanna, Krötz, Florian, Ribeiro, Andrea, Vielhauer, Volker, Nadjiri, Jonathan, Gaitzsch, Erik, Niemeyer, Markus, Porubsky, Stefan, Gröne, Hermann-Josef, Wörnle, Markus

“…In hepatitis C virus (HCV) infection, morbidity and mortality often result from extrahepatic disease manifestations. We provide evidence for a role of…”
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Advances in magnetofection—magnetically guided nucleic acid delivery by Schillinger, Ulrike, Brill, Thomas, Rudolph, Carsten, Huth, Stephanie, Gersting, Sören, Krötz, Florian, Hirschberger, Johannes, Bergemann, Christian, Plank, Christian

“…Magnetofection is nucleic acid delivery to cells supported and site-specifically guided by the attractive forces of magnetic fields acting on nucleic acid…”
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LL37 inhibits the inflammatory endothelial response induced by viral or endogenous DNA by Merkle, Monika, Pircher, Joachim, Mannell, Hanna, Krötz, Florian, Blüm, Philipp, Czermak, Thomas, Gaitzsch, Erik, Schneider, Christine, Köppel, Simone, Ribeiro, Andrea, Wörnle, Markus

“…Abstract In viral infection, morbidity and mortality often result from extrahepatic disease manifestations such as vasculitis. We hereby show that human…”
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Mycophenolate Acid Inhibits Endothelial NAD(P)H Oxidase Activity and Superoxide Formation by a Rac1-Dependent Mechanism by Krötz, Florian, Keller, Matthias, Derflinger, Sabine, Schmid, Holger, Gloe, Torsten, Bassermann, Florian, Duyster, Justus, Cohen, Clemens D, Schuhmann, Christoph, Klauss, Volker, Pohl, Ulrich, Stempfle, Hans-Ulrich, Sohn, Hae-Young

“…Endothelial dysfunction precedes hypertension and atherosclerosis and predicts cardiac allograft vasculopathy and death in heart transplant recipients…”
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Selective inhibition of cyclooxygenase-2 enhances platelet adhesion in hamster arterioles in vivo by BUERKLE, Martin A, LEHRER, Selim, SOHN, Hae-Young, CONZEN, Peter, POHL, Ulrich, KRÖTZ, Florian

“…Selective inhibitors of cyclooxygenase-2 (Cox-2) are reported to cause cardiovascular side effects in patients at risk. However, direct proof of prothrombotic…”
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Viral pathogens as novel activators of procoagulant signalling by Krötz, Florian

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NAD(P)H oxidase–dependent platelet superoxide anion release increases platelet recruitment by Krötz, Florian, Sohn, Hae Young, Gloe, Torsten, Zahler, Stefan, Riexinger, Tobias, Schiele, Thomas M., Becker, Bernhard F., Theisen, Karl, Klauss, Volker, Pohl, Ulrich

“…Platelets, although not phagocytotic, have been suggested to release O 2−. Since O 2−-producing reduced nicotinamide adenine dinucleotide (phosphate) (NAD(P)H)…”
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Targeted Endothelial Gene Delivery by Ultrasonic Destruction of Magnetic Microbubbles Carrying Lentiviral Vectors by Mannell, Hanna, Pircher, Joachim, Räthel, Thomas, Schilberg, Katharina, Zimmermann, Katrin, Pfeifer, Alexander, Mykhaylyk, Olga, Gleich, Bernhard, Pohl, Ulrich, Krötz, Florian

“…ABSTRACT Purpose Site specific vascular gene delivery is a promising tool for treatment of cardiovascular diseases. By combining ultrasound mediated…”
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Selective COX-2 inhibitors and risk of myocardial infarction by Krotz, Florian, Schiele, Thomas M, Klauss, Volker, Sohn, Hae-Young

“…Selective inhibitors of cyclooxygenase-2 (COX-2, 'coxibs') are highly effective anti-inflammatory and analgesic drugs that exert their action by preventing the…”
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Magnetofection—A highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo by Krötz, Florian, Wit, Cor de, Sohn, Hae-Young, Zahler, Stefan, Gloe, Torsten, Pohl, Ulrich, Plank, Christian

“…Delivery of antisense oligodesoxynucleotides (ODN) into primary cells is a specific strategy for research with therapeutic perspectives but…”
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The Endothelial Tyrosine Phosphatase SHP-1 Plays an Important Role for Vascular Haemostasis in TNFα-Induced Inflammation In Vivo by Krötz, Florian, Wörnle, Markus, Koch, Elisabeth, Niemeyer, Markus, Mannell, Hanna, Alig, Stefan, Pircher, Joachim, Czermak, Thomas, Gaitzsch, Erik

“…Introduction. Inflammation and endothelium-derived superoxides are important pathomechanisms in atherothrombotic diseases. We could previously show that the…”
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Response of VEGF to activation of viral receptors and TNFα in human mesangial cells by Merkle, Monika, Ribeiro, Andrea, Belling, Franziska, Mannell, Hanna, Krötz, Florian, Pircher, Joachim, Wörnle, Markus

“…Vascular endothelial growth factor (VEGF) plays an important role in glomerular homeostasis as well as in the pathogenesis of kidney diseases as…”
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