Search Results - "Krämer, Helmut"

Autophagy Keeps the Balance in Tissue Homeostasis by Buszczak, Michael, Krämer, Helmut

“…Gut cells are exposed to diverse insults that necessitate their replacement from a stem cell pool balancing differentiation and proliferation. In this issue of…”
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Cdk5-mediated Acn/Acinus phosphorylation regulates basal autophagy independently of metabolic stress by Nandi, Nilay, Krämer, Helmut

“…In neurons, autophagy counteracts consequences of aging. It is therefore of interest how basal rates of macroautophagy/autophagy can be controlled…”
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Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation by Tyra, Lauren K., Nandi, Nilay, Tracy, Charles, Krämer, Helmut

“…The expression of multiple growth-promoting genes is coordinated by the transcriptional co-activator Yorkie with its major regulatory input provided by the…”
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Allnighter pseudokinase-mediated feedback links proteostasis and sleep in Drosophila by Shekhar, Shashank, Moehlman, Andrew T., Park, Brenden, Ewnetu, Michael, Tracy, Charles, Titos, Iris, Pawłowski, Krzysztof, Tagliabracci, Vincent S., Krämer, Helmut

“…In nervous systems, retrograde signals are key for organizing circuit activity and maintaining neuronal homeostasis. We identify the conserved Allnighter (Aln)…”
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Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies by Casey, Amanda K., Moehlman, Andrew T., Zhang, Junmei, Servage, Kelly A., Krämer, Helmut, Orth, Kim

“…Protein chaperones play a critical role in proteostasis. The activity of the major endoplasmic reticulum chaperone BiP (GRP78) is regulated by Fic-mediated…”
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Intracellular Chloride and Scaffold Protein Mo25 Cooperatively Regulate Transepithelial Ion Transport through WNK Signaling in the Malpighian Tubule by Sun, Qifei, Wu, Yipin, Jonusaite, Sima, Pleinis, John M, Humphreys, John M, He, Haixia, Schellinger, Jeffrey N, Akella, Radha, Stenesen, Drew, Krämer, Helmut, Goldsmith, Elizabeth J, Rodan, Aylin R

“…With No Lysine kinase (WNK) signaling regulates mammalian renal epithelial ion transport to maintain electrolyte and BP homeostasis. Our previous studies…”
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Visual neurotransmission in Drosophila requires expression of Fic in glial capitate projections by Rahman, Mokhlasur, Ham, Hyeilin, Liu, Xinran, Sugiura, Yoshie, Orth, Kim, Krämer, Helmut

“…The authors find that the Fic domain–containing protein Fic is necessary for vision in Drosophila . Fic expression is required in the capitate projections of…”
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The glial sodium-potassium-2-chloride cotransporter is required for synaptic transmission in the Drosophila visual system by Stenesen, Drew, Moehlman, Andrew T., Schellinger, Jeffrey N., Rodan, Aylin R., Krämer, Helmut

“…The Drosophila Ncc69 gene encodes a Na + -K + -2Cl − -cotransporter (NKCC) that is critical for regulating intra- and extracellular ionic conditions in…”
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Unfolded Protein Response-regulated Drosophila Fic (dFic) Protein Reversibly AMPylates BiP Chaperone during Endoplasmic Reticulum Homeostasis by Ham, Hyeilin, Woolery, Andrew R., Tracy, Charles, Stenesen, Drew, Krämer, Helmut, Orth, Kim

“…Drosophila Fic (dFic) mediates AMPylation, a covalent attachment of adenosine monophosphate (AMP) from ATP to hydroxyl side chains of protein substrates. Here,…”
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A phosphoswitch at acinus-serine437 controls autophagic responses to cadmium exposure and neurodegenerative stress by Nandi, Nilay, Zaidi, Zuhair, Tracy, Charles, Krämer, Helmut

“…Neuronal health depends on quality control functions of autophagy, but mechanisms regulating neuronal autophagy are poorly understood. Previously, we showed…”
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In situ Dephosphorylation Assay with Recombinant Nil Phosphatase by Nandi, Nilay, Tracy, Charles, Krämer, Helmut

“…The activity of numerous autophagy-related proteins depends on their phosphorylation status, which places importance on understanding the responsible kinases…”
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Microtubule-dependent endosomal sorting of clathrin-independent cargo by Hook1 by Maldonado-Báez, Lymarie, Cole, Nelson B, Krämer, Helmut, Donaldson, Julie G

“…Many plasma membrane (PM) proteins enter cells nonselectively through clathrin-independent endocytosis (CIE). Here, we present evidence that cytoplasmic…”
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The SM protein Car/Vps33A regulates SNARE-mediated trafficking to lysosomes and lysosome-related organelles by Akbar, Mohammed A, Ray, Sanchali, Krämer, Helmut

“…The SM proteins Vps33A and Vps33B are believed to act in membrane fusions in endosomal pathways, but their specific roles are controversial. In Drosophila,…”
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The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling by Stenesen, Drew, Moehlman, Andrew T, Krämer, Helmut

“…Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by…”
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Drosophila p53 directs nonapoptotic programs in postmitotic tissue by Kurtz, Paula, Jones, Amanda E, Tiwari, Bhavana, Link, Nichole, Wylie, Annika, Tracy, Charles, Krämer, Helmut, Abrams, John M

“…is the most frequently mutated gene in human cancers, and despite intensive research efforts, genome-scale studies of p53 function in whole animal models are…”
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Adaptation to constant light requires Fic-mediated AMPylation of BiP to protect against reversible photoreceptor degeneration by Moehlman, Andrew T, Casey, Amanda K, Servage, Kelly, Orth, Kim, Krämer, Helmut

“…In response to environmental, developmental, and pathological stressors, cells engage homeostatic pathways to maintain their function. Among these pathways,…”
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Fic-mediated AMPylation tempers the unfolded protein response during physiological stress by Casey, Amanda K, Gray, Hillery F, Chimalapati, Suneeta, Hernandez, Genaro, Moehlman, Andrew T, Stewart, Nathan, Fields, Hazel A, Gulen, Burak, Servage, Kelly A, Stefanius, Karoliina, Blevins, Aubrie, Evers, Bret M, Krämer, Helmut, Orth, Kim

“…The proper balance of synthesis, folding, modification, and degradation of proteins, also known as protein homeostasis, is vital to cellular health and…”
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Drosophila mauve Mutants Reveal a Role of LYST Homologs Late in the Maturation of Phagosomes and Autophagosomes by Rahman, Mokhlasur, Haberman, Adam, Tracy, Charles, Ray, Sanchali, Krämer, Helmut

“…Chediak–Higashi syndrome (CHS) is a lethal disease caused by mutations that inactivate the lysosomal trafficking regulator protein (LYST). Patients suffer from…”
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Drosophila Vps16A is required for trafficking to lysosomes and biogenesis of pigment granules by Pulipparacharuvil, Suprabha, Akbar, Mohammed Ali, Ray, Sanchali, Sevrioukov, Evgueny A, Haberman, Adam S, Rohrer, Jack, Krämer, Helmut

“…Mutations that disrupt trafficking to lysosomes and lysosome-related organelles cause multiple diseases, including Hermansky-Pudlak syndrome. The Drosophila…”
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Fic-mediated deAMPylation is not dependent on homodimerization and rescues toxic AMPylation in flies by Casey, Amanda K., Moehlman, Andrew T., Zhang, Junmei, Servage, Kelly A., Krämer, Helmut, Orth, Kim

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