Search Results - "Krämer, Günter"

Management of epilepsy in older adults: A critical review by the ILAE Task Force on Epilepsy in the elderly by Piccenna, Loretta, O'Dwyer, Rebecca, Leppik, Ilo, Beghi, Ettore, Giussani, Giorgia, Costa, Cinzia, DiFrancesco, Jacopo C., Dhakar, Monica B., Akamatsu, Naoki, Cretin, Benjamin, Krämer, Günter, Faught, Edward, Kwan, Patrick

“…Older adults represent a highly heterogeneous population, with multiple diverse subgroups. Therefore, an individualized approach to treatment is essential to…”
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“Tell me how do I feel” – Emotion recognition and theory of mind in symptomatic mesial temporal lobe epilepsy by Broicher, Sarah D., Kuchukhidze, Giorgi, Grunwald, Thomas, Krämer, Günter, Kurthen, Martin, Jokeit, Hennric

“…► MTLE as significant risk factor for deficits in social cognition. ► Deficits beyond weaknesses that are associated with an epileptic disorder in general. ►…”
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Mechanisms of Cotranslational Maturation of Newly Synthesized Proteins by Kramer, Günter, Shiber, Ayala, Bukau, Bernd

“…The timely production of functional proteins is of critical importance for the biological activity of cells. To reach the functional state, newly synthesized…”
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Therapeutic drug monitoring of the newer antiepileptic drugs by JOHANNESSEN, Svein I, BATTINO, Dina, BERRY, David J, BIALER, Meir, KRÄMER, Günter, TOMSON, Torbjörn, PATSALOS, Philip N

“…The aim of the present review is to discuss the potential value of therapeutic drug monitoring (TDM) of the newer antiepileptic drugs (AEDs) felbamate,…”
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Cotranslational assembly of protein complexes in eukaryotes revealed by ribosome profiling by Shiber, Ayala, Döring, Kristina, Friedrich, Ulrike, Klann, Kevin, Merker, Dorina, Zedan, Mostafa, Tippmann, Frank, Kramer, Günter, Bukau, Bernd

“…The folding of newly synthesized proteins to the native state is a major challenge within the crowded cellular environment, as non-productive interactions can…”
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The ribosome as a platform for co-translational processing, folding and targeting of newly synthesized proteins by Ban, Nenad, Bukau, Bernd, Kramer, Günter, Boehringer, Daniel

“…The early events in the life of newly synthesized proteins in the cellular environment are remarkably complex. Concurrently with their synthesis by the…”
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Interactions between nascent proteins translated by adjacent ribosomes drive homomer assembly by Bertolini, Matilde, Fenzl, Kai, Kats, Ilia, Wruck, Florian, Tippmann, Frank, Schmitt, Jaro, Auburger, Josef Johannes, Tans, Sander, Bukau, Bernd, Kramer, Günter

“…Accurate assembly of newly synthesized proteins into functional oligomers is crucial for cell activity. In this study, we investigated whether direct…”
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Selective 40S Footprinting Reveals Cap-Tethered Ribosome Scanning in Human Cells by Bohlen, Jonathan, Fenzl, Kai, Kramer, Günter, Bukau, Bernd, Teleman, Aurelio A.

“…Translation regulation occurs largely during the initiation phase. Here, we develop selective 40S footprinting to visualize initiating 40S ribosomes on…”
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Structure and function of the molecular chaperone Trigger Factor by Hoffmann, Anja, Bukau, Bernd, Kramer, Günter

“…Newly synthesized proteins often require the assistance of molecular chaperones to efficiently fold into functional three-dimensional structures. At first,…”
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Condensation of Ded1p Promotes a Translational Switch from Housekeeping to Stress Protein Production by Iserman, Christiane, Desroches Altamirano, Christine, Jegers, Ceciel, Friedrich, Ulrike, Zarin, Taraneh, Fritsch, Anatol W., Mittasch, Matthäus, Domingues, Antonio, Hersemann, Lena, Jahnel, Marcus, Richter, Doris, Guenther, Ulf-Peter, Hentze, Matthias W., Moses, Alan M., Hyman, Anthony A., Kramer, Günter, Kreysing, Moritz, Franzmann, Titus M., Alberti, Simon

“…Cells sense elevated temperatures and mount an adaptive heat shock response that involves changes in gene expression, but the underlying mechanisms,…”
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Reshaping of the conformational search of a protein by the chaperone trigger factor by Mashaghi, Alireza, Kramer, Günter, Bechtluft, Philipp, Zachmann-Brand, Beate, Driessen, Arnold J. M., Bukau, Bernd, Tans, Sander J.

“…The bacterial chaperone named trigger factor is found to stabilize protein folding intermediates that eventually convert to the native state, suggesting that…”
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Co-translational mechanisms of protein maturation by Gloge, Felix, Becker, Annemarie H, Kramer, Günter, Bukau, Bernd

“…•Co-translational folding is influenced by translational pausing mechanisms.•The ribosome is providing a folding environment for nascent chains.•Action of…”
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SecA Cotranslationally Interacts with Nascent Substrate Proteins In Vivo by Huber, Damon, Jamshad, Mohammed, Hanmer, Ruby, Schibich, Daniela, Döring, Kristina, Marcomini, Isabella, Kramer, Günter, Bukau, Bernd

“…SecA is an essential component of the Sec machinery in bacteria, which is responsible for transporting proteins across the cytoplasmic membrane. Recent work…”
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Operon structure and cotranslational subunit association direct protein assembly in bacteria by Shieh, Yu-Wei, Minguez, Pablo, Bork, Peer, Auburger, Josef J., Guilbride, D. Lys, Kramer, Günter, Bukau, Bernd

“…Assembly of protein complexes is considered a posttranslational process involving random collision of subunits. We show that within the Escherichia coli…”
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DENR promotes translation reinitiation via ribosome recycling to drive expression of oncogenes including ATF4 by Bohlen, Jonathan, Harbrecht, Liza, Blanco, Saioa, Clemm von Hohenberg, Katharina, Fenzl, Kai, Kramer, Günter, Bukau, Bernd, Teleman, Aurelio A.

“…Translation efficiency varies considerably between different mRNAs, thereby impacting protein expression. Translation of the stress response master-regulator…”
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Selective ribosome profiling as a tool for studying the interaction of chaperones and targeting factors with nascent polypeptide chains and ribosomes by Becker, Annemarie H, Oh, Eugene, Weissman, Jonathan S, Kramer, Günter, Bukau, Bernd

“…A plethora of factors is involved in the maturation of newly synthesized proteins, including chaperones, membrane targeting factors and enzymes. Many factors…”
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Trigger Factor Reduces the Force Exerted on the Nascent Chain by a Cotranslationally Folding Protein by Nilsson, Ola B., Müller-Lucks, Annika, Kramer, Günter, Bukau, Bernd, von Heijne, Gunnar

“…Cotranslational protein folding can generate pulling forces on the nascent chain that can affect the instantaneous translation rate and thereby possibly feed…”
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Selective Ribosome Profiling Reveals the Cotranslational Chaperone Action of Trigger Factor In Vivo by Oh, Eugene, Becker, Annemarie H., Sandikci, Arzu, Huber, Damon, Chaba, Rachna, Gloge, Felix, Nichols, Robert J., Typas, Athanasios, Gross, Carol A., Kramer, Günter, Weissman, Jonathan S., Bukau, Bernd

“…As nascent polypeptides exit ribosomes, they are engaged by a series of processing, targeting, and folding factors. Here, we present a selective ribosome…”
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A chemical kinetic basis for measuring translation initiation and elongation rates from ribosome profiling data by Sharma, Ajeet K, Sormanni, Pietro, Ahmed, Nabeel, Ciryam, Prajwal, Friedrich, Ulrike A, Kramer, Günter, O'Brien, Edward P

“…Analysis methods based on simulations and optimization have been previously developed to estimate relative translation rates from next-generation sequencing…”
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Selective ribosome profiling to study interactions of translating ribosomes in yeast by Galmozzi, Carla V., Merker, Dorina, Friedrich, Ulrike A., Döring, Kristina, Kramer, Günter

“…A number of enzymes, targeting factors and chaperones engage ribosomes to support fundamental steps of nascent protein maturation, including enzymatic…”
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