Search Results - "Kozyrev, Sergey V."

Elevated levels of IL-12/IL-23p40 in Nova Scotia Duck Tolling Retrievers with autoimmune disease and lymphoma by Nilsson, Malin, Kozyrev, Sergey V., Saellström, Sara, Johansson, Siri, Andersson, Göran, Lindblad-Toh, Kerstin, Hansson-Hamlin, Helene, Rönnberg, Henrik

“…The Nova Scotia Duck Tolling Retriever (NSDTR) is predisposed to immune mediated rheumatic disease (IMRD), steroid-responsive meningitis-arteritis (SRMA) and…”
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In sickness and health - a questionnaire based study regarding immune mediated diseases and neoplasia in Swedish Nova Scotia Duck Tolling Retrievers by Nilsson, Malin, Kozyrev, Sergey V, Lindblad-Toh, Kerstin, Rönnberg, Henrik, Hansson-Hamlin, Helene

“…The Nova Scotia Duck Tolling Retriever (NSDTR) has previously been highlighted as a breed at risk for developing immune mediated diseases and cancer. The…”
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Hierarchical Structure of Protein Sequence by Nekrasov, Alexei, Kozmin, Yuri, Kozyrev, Sergey, Ziganshin, Rustam, de Brevern, Alexandre, Anashkina, Anastasia

“…Most non-communicable diseases are associated with dysfunction of proteins or protein complexes. The relationship between sequence and structure has been…”
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A survey of ficolin-3 activity in Systemic Lupus Erythematosus reveals a link to hematological disease manifestations and autoantibody profile by Lindelöf, Linnea, Rantapää-Dahlqvist, Solbritt, Lundtoft, Christian, Sandling, Johanna K., Leonard, Dag, Sayadi, Ahmed, Rönnblom, Lars, Enocsson, Helena, Sjöwall, Christopher, Jönsen, Andreas, Bengtsson, Anders A., Hong, Mun-Gwan, Diaz-Gallo, Lina-Marcela, Bianchi, Matteo, Kozyrev, Sergey V., Lindblad-Toh, Kerstin, Nilsson Ekdahl, Kristina, Nilsson, Bo, Gunnarsson, Iva, Svenungsson, Elisabet, Eriksson, Oskar

“…The complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical pathway…”
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Variants within the SP110 nuclear body protein modify risk of canine degenerative myelopathy by Ivansson, Emma L., Megquier, Kate, Kozyrev, Sergey V., Murén, Eva, Körberg, Izabella Baranowska, Swofford, Ross, Koltookian, Michele, Tonomura, Noriko, Zeng, Rong, Kolicheski, Ana L., Hansen, Liz, Katz, Martin L., Johnson, Gayle C., Johnson, Gary S., Coates, Joan R., Lindblad-Toh, Kerstin

“…Canine degenerative myelopathy (DM) is a naturally occurring neurodegenerative disease with similarities to some forms of amyotrophic lateral sclerosis (ALS)…”
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Multiple Changes of Gene Expression and Function Reveal Genomic and Phenotypic Complexity in SLE-like Disease by Wilbe, Maria, Kozyrev, Sergey V, Farias, Fabiana H G, Bremer, Hanna D, Hedlund, Anna, Pielberg, Gerli R, Seppälä, Eija H, Gustafson, Ulla, Lohi, Hannes, Carlborg, Örjan, Andersson, Göran, Hansson-Hamlin, Helene, Lindblad-Toh, Kerstin

“…The complexity of clinical manifestations commonly observed in autoimmune disorders poses a major challenge to genetic studies of such diseases. Systemic lupus…”
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Mer-tyrosine kinase: a novel susceptibility gene for SLE related end-stage renal disease by Yavuz, Sule, Pucholt, Pascal, Sandling, Johanna K, Bianchi, Matteo, Leonard, Dag, Bolin, Karin, Imgenberg-Kreuz, Juliana, Eloranta, Maija-Leena, Kozyrev, Sergey V, Lanata, Cristina M, Jönsen, Andreas, Bengtsson, Anders A, Sjöwall, Christopher, Svenungsson, Elisabet, Gunnarsson, Iva, Rantapää-Dahlqvist, Solbritt, Nititham, Joanne, Criswell, Lindsey A, Lindblad-Toh, Kerstin, Rönnblom, Lars

“…ObjectiveLupus nephritis (LN) is a common and severe manifestation of SLE. The genetic risk for nephritis and progression to end-stage renal disease (ESRD) in…”
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Promoter Insertion/Deletion in the IRF5 Gene Is Highly Associated with Susceptibility to Systemic Lupus Erythematosus in Distinct Populations, But Exerts a Modest Effect on Gene Expression in Peripheral Blood Mononuclear Cells by LÖFGREN, SARA E., YIN, HONG, DELGADO-VEGA, ANGELICA M., SANCHEZ, ELENA, LEWÉN, SUSANNA, PONS-ESTEL, BERNARDO A., WITTE, TORSTEN, D’ALFONSO, SANDRA, ORTEGO-CENTENO, NORBERTO, MARTIN, JAVIER, ALARCÓN-RIQUELME, MARTA E., KOZYREV, SERGEY V.

“…Objective. We examined the genetic association of the promoter insertion/deletion (indel) in IRF5 gene with systemic lupus erythematosus (SLE) in distinct…”
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Aperiodic crystals, Riemann zeta function, and primes by Madison, Alexey E., Madison, Pavel A., Kozyrev, Sergey V.

“…The distribution of Riemann zeros may represent a spectrum of a certain point distribution. Potentially suitable distributions were synthesized by summing…”
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Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing by Sandling, Johanna K, Pucholt, Pascal, Hultin Rosenberg, Lina, Farias, Fabiana H G, Kozyrev, Sergey V, Eloranta, Maija-Leena, Alexsson, Andrei, Bianchi, Matteo, Padyukov, Leonid, Bengtsson, Christine, Jonsson, Roland, Omdal, Roald, Lie, Benedicte A, Massarenti, Laura, Steffensen, Rudi, Jakobsen, Marianne A, Lillevang, Søren T, Lerang, Karoline, Molberg, Øyvind, Voss, Anne, Troldborg, Anne, Jacobsen, Søren, Syvänen, Ann-Christine, Jönsen, Andreas, Gunnarsson, Iva, Svenungsson, Elisabet, Rantapää-Dahlqvist, Solbritt, Bengtsson, Anders A, Sjöwall, Christopher, Leonard, Dag, Lindblad-Toh, Kerstin, Rönnblom, Lars

“…Systemic lupus erythematosus (SLE) is an autoimmune disease with extensive heterogeneity in disease presentation between patients, which is likely due to an…”
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Unraveling the Genetics of Shared Clinical and Serological Manifestations in Patients With Systemic Inflammatory Autoimmune Diseases by Bianchi, Matteo, Kozyrev, Sergey V., Notarnicola, Antonella, Sandling, Johanna K., Pettersson, Mats, Leonard, Dag, Sjöwall, Christopher, Gunnarsson, Iva, Rantapää‐Dahlqvist, Solbritt, Bengtsson, Anders A., Jönsen, Andreas, Svenungsson, Elisabet, Enocsson, Helena, Kvarnström, Marika, Forsblad‐d'Elia, Helena, Bucher, Sara Magnusson, Norheim, Katrine B., Baecklund, Eva, Jonsson, Roland, Hammenfors, Daniel, Eriksson, Per, Mandl, Thomas, Omdal, Roald, Padyukov, Leonid, Andersson, Helena, Molberg, Øyvind, Diederichsen, Louise Pyndt, Syvänen, Ann‐Christine, Wahren‐Herlenius, Marie, Nordmark, Gunnel, Lundberg, Ingrid E., Rönnblom, Lars, Lindblad‐Toh, Kerstin

“…Objective Systemic inflammatory autoimmune diseases (SIADs) such as systemic lupus erythematosus (SLE), primary Sjögren disease (pSS), and idiopathic…”
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Functional variants in the B-cell gene BANK1 are associated with systemic lupus erythematosus by Kozyrev, Sergey V, Wojcik, Jerome, Barizzone, Nadia, González-Escribano, Maria Francisca, Zaghlool, Ammar, Sturfelt, Gunnar, Pons-Estel, Bernardo A, Svenungsson, Elisabet, Junker, Peter, Sanchez, Elena, Martin, Javier, Jönsen, Andreas, Gutierrez, Carmen, Suarez, Ana, Linga Reddy, M V Prasad, Abelson, Anna-Karin, Gunnarsson, Iva, Laustrup, Helle, Truedsson, Lennart, D'Alfonso, Sandra, Abderrahim, Hadi, Alarcón-Riquelme, Marta E, Witte, Torsten, Danieli, Maria Giovanna

“…Systemic lupus erythematosus (SLE) is a prototypical autoimmune disease characterized by production of autoantibodies and complex genetic inheritance. In a…”
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A common haplotype of interferon regulatory factor 5 ( IRF5 ) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus by Escribano, Ma Francisca González, Collaborative Groups, the Argentine and Spanish, Graham, Robert R, Baechler, Emily C, Reddy, M V Prasad Linga, Kozyrev, Sergey V, Bauer, Jason W, Martín, Javier, Gregersen, Peter K, Pons-Estel, Bernardo, Alarcón-Riquelme, Marta E, Behrens, Timothy W, Plenge, Robert M, Koeuth, Thearith, Daly, Mark, Altshuler, David, Ortmann, Ward A, Petri, Michelle

“…Systemic lupus erythematosus (SLE) is a complex autoimmune disease characterized by activation of the type I interferon (IFN) pathway. Here we convincingly…”
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Whole Exome Sequencing of Patients from Multicase Families with Systemic Lupus Erythematosus Identifies Multiple Rare Variants by Delgado-Vega, Angélica M., Martínez-Bueno, Manuel, Oparina, Nina Y., López Herráez, David, Kristjansdottir, Helga, Steinsson, Kristján, Kozyrev, Sergey V., Alarcón-Riquelme, Marta E.

“…In an effort to identify rare alleles associated with SLE, we have performed whole exome sequencing of the most distantly related affected individuals from two…”
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A rare regulatory variant in the MEF2D gene affects gene regulation and splicing and is associated with a SLE sub-phenotype in Swedish cohorts by Farias, Fabiana H G, Dahlqvist, Johanna, Kozyrev, Sergey V, Leonard, Dag, Wilbe, Maria, Abramov, Sergei N, Alexsson, Andrei, Pielberg, Gerli R, Hansson-Hamlin, Helene, Andersson, Göran, Tandre, Karolina, Bengtsson, Anders A, Sjöwall, Christopher, Svenungsson, Elisabet, Gunnarsson, Iva, Rantapää-Dahlqvist, Solbritt, Syvänen, Ann-Christine, Sandling, Johanna K, Eloranta, Maija-Leena, Rönnblom, Lars, Lindblad-Toh, Kerstin

“…Systemic lupus erythematosus (SLE) is an autoimmune disorder with heterogeneous clinical presentation and complex etiology involving the interplay between…”
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O16 pQTL analysis of ficolin-3 activity reveals a link between the lectin pathway of complement and hematological disease manifestations in systemic lupus erythematosus by Lindelöf, Linnea, Rantapää-Dahlqvist, Solbritt, Lundtoft, Christian, Sandling, Johanna K, Leonard, Dag, Sayadi, Ahmed, Rönnblom, Lars, Enocsson, Helena, Sjöwall, Christopher, Jönsen, Andreas, Bengtsson, Anders A, Hong, Mun-Gwan, Diaz-Gallo, Lina-Marcela, Bianchi, Matteo, Kozyrev, Sergey V, Lindblad-Toh, Kerstin, Ekdahl, Kristina Nilsson, Nilsson, Bo, Gunnarsson, Iva, Svenungsson, Elisabet, Eriksson, Oskar

“…ObjectiveThe complement system plays a central role in the pathogenesis of Systemic Lupus Erythematosus (SLE), but most studies have focused on the classical…”
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P13 Acquired ficolin-3 deficiency in patients with systemic lupus erythematosus by Lindelöf, Linnea, Rantapää-Dahlqvist, Solbritt, Lundtoft, Christian, Sandling, Johanna K, Leonard, Dag, Sayadi, Ahmed, Rönnblom, Lars, Enocsson, Helena, Sjöwall, Christopher, Jönsen, Andreas, Bengtsson, Anders A, Hong, Mun-Gwan, Diaz-Gallo, Lina-Marcela, Bianchi, Matteo, Kozyrev, Sergey V, Lindblad-Toh, Kerstin, Ekdahl, Kristina Nilsson, Nilsson, Bo, Gunnarsson, Iva, Svenungsson, Elisabet, Eriksson, Oskar

“…ObjectiveFicolin-3 is the main initiator of the lectin pathway of complement in humans. Case reports of ficolin-3 deficient patients have suggested that…”
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PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6 by Oparina, Nina Y, Delgado-Vega, Angelica M, Martinez-Bueno, Manuel, Magro-Checa, César, Fernández, Concepción, Castro, Rafaela Ortega, Pons-Estel, Bernardo A, D'Alfonso, Sandra, Sebastiani, Gian Domenico, Witte, Torsten, Lauwerys, Bernard R, Endreffy, Emoke, Kovács, László, Escudero, Alejandro, López-Pedrera, Chary, Vasconcelos, Carlos, da Silva, Berta Martins, Frostegård, Johan, Truedsson, Lennart, Martin, Javier, Raya, Enrique, Ortego-Centeno, Norberto, de Los Angeles Aguirre, Maria, de Ramón Garrido, Enrique, Palma, María-Jesús Castillo, Alarcon-Riquelme, Marta E, Kozyrev, Sergey V

“…To perform fine mapping of the PXK locus associated with systemic lupus erythematosus (SLE) and study functional effects that lead to susceptibility to the…”
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The genetics and biology of Irf5-mediated signaling in lupus by Kozyrev, Sergey V., Alarcon-Riquelme, Marta E.

“…Recently much attention was attracted to the importance of the type I interferon pathway in the initiation and development of the autoimmune disease systemic…”
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Fine mapping and conditional analysis identify a new mutation in the autoimmunity susceptibility gene BLK that leads to reduced half-life of the BLK protein by Delgado-Vega, Angélica M, Dozmorov, Mikhail G, Quirós, Manuel Bernal, Wu, Ying-Yu, Martínez-García, Belén, Kozyrev, Sergey V, Frostegård, Johan, Truedsson, Lennart, de Ramón, Enrique, González-Escribano, María F, Ortego-Centeno, Norberto, Pons-Estel, Bernardo A, D'Alfonso, Sandra, Sebastiani, Gian Domenico, Witte, Torsten, Lauwerys, Bernard R, Endreffy, Emoke, Kovács, László, Vasconcelos, Carlos, da Silva, Berta Martins, Wren, Jonathan D, Martin, Javier, Castillejo-López, Casimiro, Alarcón-Riquelme, Marta E

“…To perform fine mapping of the autoimmunity susceptibility gene BLK and identify functional variants involved in systemic lupus erythematosus (SLE). Genotyping…”
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