Longitudinal study of risk factors for decreased cross-sectional area of psoas major and paraspinal muscle in 1849 individuals

This 10-year retrospective observational study investigated longitudinal losses in psoas major and paraspinal muscle area in 1849 healthy individuals (1690 male, 159 female) screened using computed tomography. Logistic regression analysis revealed significant decreases in psoas major and paraspinal...

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Bibliographic Details
Published in:	Scientific reports Vol. 11; no. 1; pp. 1 - 9
Main Authors:	Murata, Yoichi, Nakamura, Eiichiro, Tsukamoto, Manabu, Nakagawa, Toru, Takeda, Masaru, Kozuma, Mio, Kadomura, Takayuki, Narusawa, Kenichiro, Shimizu, Kenji, Uchida, Soshi, Hayashi, Takeshi, Sakai, Akinori
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 20-08-2021 Nature Publishing Group Nature Portfolio
Subjects:	692/1537/805 692/308/174 Age groups Aging Back pain Body mass index Calories Computed tomography Confidence intervals Environmental health Hospitals Humanities and Social Sciences Longitudinal studies Low back pain Medical imaging multidisciplinary Multivariate analysis Muscle strength Musculoskeletal system Observational studies Orthopedics Physical activity Regression analysis Risk factors Risk reduction Sarcopenia Science Science (multidisciplinary) Sexes Surgery
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Summary:	This 10-year retrospective observational study investigated longitudinal losses in psoas major and paraspinal muscle area in 1849 healthy individuals (1690 male, 159 female) screened using computed tomography. Logistic regression analysis revealed significant decreases in psoas major and paraspinal muscle area at 10 years relative to the baseline area regardless of age or sex, starting at 30 years of age. Only aging [≥ 50 s (odds ratio [OR]: 1.72; 95% confidence interval [CI] 1.05–2.84; p = 0.03) and ≥ 60 s (OR: 2.67; 95% CI 1.55–4.60; p < 0.001)] was a risk factor for decreases in psoas major area. Age ≥ 60 years (OR: 2.05; 95% CI 1.24–3.39; p = 0.005), body mass index ≥ 25 kg/m 2 (OR: 1.32; 95% CI 1.01–1.73; p = 0.04), and visceral fat ≥ 100 cm 2 (OR: 1.61; 95% CI 1.20–2.15; p = 0.001) were risk factors for decreases in paraspinal muscle area. Physical activity ≥ 900 kcal/week (OR: 0.68; 95% CI 0.50–0.94; p = 0.02) attenuated paraspinal muscle area loss in male. Our study demonstrated that walking > 45 min daily (Calories = METs (walking: 3.0) × duration of time (h) × weight (60 kg) × 1.05) can reduce paraspinal muscle loss, which may in turn decrease the risk of falls, low-back pain, and sarcopenia.
ISSN:	2045-2322 2045-2322
DOI:	10.1038/s41598-021-96448-8