Search Results - "Kozono, Toshiro"

Factor VIIa inhibitors: Target hopping in the serine protease family using X-ray structure determination by Shiraishi, Takuya, Kadono, Shojiro, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Iikura, Hitoshi, Esaki, Tohru, Koga, Takaki, Hattori, Kunihiro, Watanabe, Yoshiaki, Sakamoto, Akihisa, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Esaki, Keiko, Ohta, Masateru, Sato, Haruhiko, Kozono, Toshiro

“…We succeeded in target hopping in the serine protease family using crystal structures of human FVIIa/TF in complex with peptide mimetic inhibitors. Selective…”
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Design and Synthesis of Peptidomimetic Factor VIIa Inhibitors by Shiraishi, Takuya, Kadono, Shojiro, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Iikura, Hitoshi, Esaki, Tohru, Koga, Takaki, Hattori, Kunihiro, Watanabe, Yoshiaki, Sakamoto, Akihisa, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Esaki, Keiko, Ohta, Masateru, Sato, Haruhiko, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is regarded as a promising target for developing new anticoagulant drugs. In previous…”
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Structure-based design of P3 moieties in the peptide mimetic factor VIIa inhibitor by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Suzuki, Tsukasa, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. Structure-based designs…”
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Novel interactions of large P3 moiety and small P4 moiety in the binding of the peptide mimetic factor VIIa inhibitor by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Yoshihashi, Kazutaka, Kitazawa, Takehisa, Suzuki, Tsukasa, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…Selective factor VIIa-tissue factor complex (FVIIa/TF) inhibition is seen as a promising target for developing new anticoagulant drugs. A novel peptide mimetic…”
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Design and Synthesis of N-terminal Cyclic Motilin Partial Peptides: A Novel Pure Motilin Antagonist by HARAMURA, Masayuki, OKAMACHI, Akira, TSUZUKI, Kouichi, YOGO, Kenji, IKUTA, Makoto, KOZONO, Toshiro, TAKANASHI, Hisanori, MURAYAMA, Eigoro

“…Motilin antagonist was designed and synthesized on the basis of the structure-activity relationship analysis of porcine motilin that we reported recently. The…”
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Structure-Activity Study of Intact Porcine Motilin by HARAMURA, Masayuki, TSUZUKI, Kouichi, OKAMACHI, Akira, YOGO, Kenji, IKUTA, Makoto, KOZONO, Toshiro, TAKANASHI, Hisanori, MURAYAMA, Eigoro

“…Biologically important sites on intact porcine motilin (pMTL) were explored using its partial peptides. The partial peptides were synthesized using Fmoc…”
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Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D3 Analogues, Including 2-epi-ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity by SAITO, Nozomi, SUHARA, Yoshitomo, KURIHARA, Masaaki, FUJISHIMA, Toshie, HONZAWA, Shinobu, TAKAYANAGI, Hitoshi, KOZONO, Toshiro, MATSUMOTO, Masahiko, OHMORI, Masayuki, MIYATA, Naoki, TAKAYAMA, Hiroaki, KITTAKA, Atsushi

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Discovery and structure–activity relationship of coumarin derivatives as TNF-α inhibitors by Cheng, Jie-Fei, Chen, Mi, Wallace, David, Tith, Sovouthy, Arrhenius, Thomas, Kashiwagi, Hirotaka, Ono, Yoshiyuki, Ishikawa, Akira, Sato, Haruhiko, Kozono, Toshiro, Sato, Hediki, Nadzan, Alex M.

“…A series of coumarin-based TNF-α inhibitors 1 has been synthesized to establish structure–activity relationship. The discovery and structure–activity…”
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Industrial Synthesis of Maxacalcitol, the Antihyperparathyroidism and Antipsoriatic Vitamin D3 Analogue Exhibiting Low Calcemic Activity by Shimizu, Hitoshi, Shimizu, Kazuki, Kubodera, Noboru, Mikami, Tetsuhiro, Tsuzaki, Kaname, Suwa, Hiroyuki, Harada, Koji, Hiraide, Akira, Shimizu, Motoki, Koyama, Kaichiro, Ichikawa, Yoshihide, Hirasawa, Daisuke, Kito, Yasushi, Kobayashi, Mio, Kigawa, Masaharu, Kato, Masahiro, Kozono, Toshiro, Tanaka, Hideki, Tanabe, Makoto, Iguchi, Masanori, Yoshida, Mitsutaka

“…Maxacalcitol, the 22-oxa-derivative of 1α,25-dihydroxyvitamin D3 and used currently as an antihyperparathyroidism and antipsoriatic drug, has been synthesized…”
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Crystal structure of human factor VIIa/tissue factor in complex with peptide mimetic inhibitor by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…The 3D structure of human factor VIIa/soluble tissue factor in complex with a peptide mimetic inhibitor, propylsulfonamide- d-Thr-Met- p-aminobenzamidine, is…”
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Design and efficient synthesis of 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D3 Analogues, including 2-epi-ED-71 and their 20-epimers with HL-60 cell differentiation activity by Saito, Nozomi, Suhara, Yoshitomo, Kurihara, Masaaki, Fujishima, Toshie, Honzawa, Shinobu, Takayanagi, Hitoshi, Kozono, Toshiro, Matsumoto, Masahiko, Ohmori, Masayuki, Miyata, Naoki, Takayama, Hiroaki, Kittaka, Atsushi

“…A concise and efficient synthetic approach to 2 alpha-(omega-hydroxyalkoxy)-1 alpha,25-dihydroxyvitamin D(3) (4a-c), including 2-epi-ED-71, was developed…”
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Design and Efficient Synthesis of 2α-(ω-Hydroxyalkoxy)-1α,25-dihydroxyvitamin D 3 Analogues, Including 2- e pi -ED-71 and Their 20-Epimers with HL-60 Cell Differentiation Activity by Saito, Nozomi, Suhara, Yoshitomo, Kurihara, Masaaki, Fujishima, Toshie, Honzawa, Shinobu, Takayanagi, Hitoshi, Kozono, Toshiro, Matsumoto, Masahiko, Ohmori, Masayuki, Miyata, Naoki, Takayama, Hiroaki, Kittaka, Atsushi

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Discovery and structure-activity relationship of coumarin derivatives as TNF-α inhibitors by CHENG, Jie-Fei, MI CHEN, SATO, Hediki, NADZAN, Alex M, WALLACE, David, TITH, Sovouthy, ARRHENIUS, Thomas, KASHIWAGI, Hirotaka, ONO, Yoshiyuki, ISHIKAWA, Akira, SATO, Haruhiko, KOZONO, Toshiro

“…The discovery and structure-activity relationship of a novel series of coumarin-based TNF-alpha inhibitors is described. Starting from the initial lead 1a,…”
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Design and Synthesis of Novel Tetra-Peptide Motilin Agonists by Haramura, Masayuki, Tsuzuki, Kouichi, Okamachi, Akira, Yogo, Kenji, Ikuta, Makoto, Kozono, Toshiro, Takanashi, Hisanori, Murayama, Eigoro

“…A series of novel tetra-peptide motilin agonists, having the general structure H-Phe-Val-X-Ile-NH 2, were designed, on the basis of structure–activity…”
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Design and Synthesis of Motilin Antagonists Derived from the [1−4] Fragment of Porcine Motilin by Haramura, Masayuki, Okamachi, Akira, Tsuzuki, Kouichi, Yogo, Kenji, Ikuta, Makoto, Kozono, Toshiro, Takanashi, Hisanori, Murayama, Eigoro

“…A series of cyclic peptides having the general structure H-Phe-c[-Nε-Lys-X-NH-(CH2) n -CO-] were designed on the basis of structure−activity relationship…”
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Industrial Synthesis of Maxacalcitol, the Antihyperparathyroidism and Antipsoriatic Vitamin D 3 Analogue Exhibiting Low Calcemic Activity by Shimizu, Hitoshi, Shimizu, Kazuki, Kubodera, Noboru, Mikami, Tetsuhiro, Tsuzaki, Kaname, Suwa, Hiroyuki, Harada, Koji, Hiraide, Akira, Shimizu, Motoki, Koyama, Kaichiro, Ichikawa, Yoshihide, Hirasawa, Daisuke, Kito, Yasushi, Kobayashi, Mio, Kigawa, Masaharu, Kato, Masahiro, Kozono, Toshiro, Tanaka, Hideki, Tanabe, Makoto, Iguchi, Masanori, Yoshida, Mitsutaka

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Design and Synthesis of N-terminal Cyclic Motilin Partial Peptides by HARAMURA, Masayuki, OKAMACHI, Akira, TSUZUKI, Kouichi, YOGO, Kenji, IKUTA, Makoto, KOZONO, Toshiro, TAKANASHI, Hisanori, MURAYAMA, Eigoro

“…Motilin antagonist was designed and synthesized on the basis of the structure-activity relationship analysis of porcine motilin that we reported recently. The…”
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Structure of human factor VIIa/tissue factor in complex with a peptide-mimetic inhibitor: high selectivity against thrombin by introducing two charged groups in P2 and P4 by Kadono, Shojiro, Sakamoto, Akihisa, Kikuchi, Yasufumi, Oh-eda, Masayoshi, Yabuta, Naohiro, Koga, Takaki, Hattori, Kunihiro, Shiraishi, Takuya, Haramura, Masayuki, Kodama, Hirofumi, Ono, Yoshiyuki, Esaki, Toru, Sato, Haruhiko, Watanabe, Yoshiaki, Itoh, Susumu, Ohta, Masateru, Kozono, Toshiro

“…The crystal structure of human factor VIIa/soluble tissue factor (FVIIa/sTF) in complex with a highly selective peptide‐mimetic FVIIa inhibitor which shows…”
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Synthesis and biological activity of KCB-328 and its analogues: Novel class III antiarrhythmic agents with little reverse frequency dependence by Kim, Dong-Ick, Kim, Hak-Yeop, Kwon, Lae-Sung, Park, Sung-Dae, Jeon, Gee-Ho, Jung, Kyung-Yun, Min, Jae-Ki, Nam, Woong-Hyun, Lee, Kiho, Chung, You-Sup, Tanabe, Shigeru, Kozono, Toshiro

“…A series of 3,4-dimethoxyphenethylamine derivatives was prepared, and their prolongation effects on effective refractory period of contractile response (ERPc)…”
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Flat revertant inducers, styryl diphenylamine derivatives, inhibit growth and metastasis of murine tumor cells in vivo by Ohizumi, I, Tanemura, M, Tsunenari, T, Sato, K, Kozono, T, Kaiho, S

“…Previously, we reported that a novel styryl diphenylamine derivative, RX-465, reverts the transformed phenotype of human fibrosarcoma HT1080 cells in vitro. To…”
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