Search Results - "Kozlowski, R Z"

Relationship between membrane potential, delayed rectifier K+ currents and hypoxia in rat pulmonary arterial myocytes by Turner, J L, Kozlowski, R Z

“…Pulmonary arteries constrict in response to hypoxia, a process thought to involve oxygen sensing by K+ channels. We therefore investigated the effects of…”
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Ca(2+)-activated Cl- currents in pulmonary arterial myocytes by Clapp, L H, Turner, J L, Kozlowski, R Z

“…Currents from smooth muscle cells isolated from the pulmonary arterial tree of the rat were recorded under voltage clamp using the whole cell configuration of…”
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Electrophysiological effects of endothelin‐1 and their relationship to contraction in rat renal arterial smooth muscle by Betts, Luisa C, Kozlowski, Roland Z

“…The electophysiological effects of endothelin‐1 (ET‐1) and their relationship to contraction remain unclear in the renal circulation. Using endotheliumdenuded…”
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Differential effects of hypoxia on the intracellular Ca2+ concentration of myocytes isolated from different regions of the rat pulmonary arterial tree by Bakhramov, A, Evans, A M, Kozlowski, R Z

“…Hypoxic pulmonary vasoconstriction (HPV) may be mediated, in part, by an oxygen-sensing mechanism intrinsic to pulmonary arterial smooth muscle. It has been…”
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Kv channel subunit expression in rat pulmonary arteries by Davies, A R, Kozlowski, R Z

“…Hypoxic pulmonary vasoconstriction (HPV) is a mechanism whereby capillary perfusion is modulated to match alveolar ventilation by diverting blood flow away…”
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Turnover rate of the cardiac Na(+)-Ca2+ exchanger in guinea-pig ventricular myocytes by Powell, T, Noma, A, Shioya, T, Kozlowski, R Z

“…1. Single guinea-pig ventricular myocytes were voltage clamped using the whole-cell configuration of the patch-clamp technique and membrane current generated…”
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Ion channels, oxygen sensation and signal transduction in pulmonary arterial smooth muscle by Kozlowski, R Z

“…In contrast to systemic arteries those of the pulmonary circulation constrict in response to hypoxia: a mechanism known as "hypoxic pulmonary vasoconstriction"…”
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Dual effects of diazoxide on ATP‐K+ currents recorded from an insulin‐secreting cell line by Kozlowski, R.Z., Hales, C.N., Ashford, M.L.J.

“…1 The effects of diazoxide on ATP‐K+ channel currents, recorded from the insulin‐secreting cell line, CRI‐G1, were studied using patch‐clamp techniques. 2…”
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Functional Evidence for a Novel Suramin-Insensitive Pyrimidine Receptor in Rat Small Pulmonary Arteries by Hartley, S. Anthony, Kato, Kenichi, Salter, Katie J, Kozlowski, Roland Z

“…Uridine nucleotides are known to cause constriction of pulmonary arterial smooth muscle. However, the P2 receptor subtypes underlying the contractile effects…”
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Endothelin receptor coupling to potassium and chloride channels in isolated rat pulmonary arterial myocytes by Salter, K J, Kozlowski, R Z

“…Endothelin (endothelin)-1 may in important role in the control of pulmonary arterial tone, part of its action being due to a putative ability to regulate…”
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Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide‐sensitive channels in an insulin‐secreting cell line by Sturgess, N.C., Kozlowski, R.Z., Carrington, C.A., Hales, C.N., Ashford, M.L.J.

“…1 The effects of various sulphonylureas and diazoxide on insulin secretion and the activity of various channels have been studied using tissue culture and…”
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A novel anionic conductance affects action potential duration in isolated rat ventricular myocytes by Spencer, C Ian, Uchida, Wataru, Kozlowski, Roland Z

“…Effects of extracellular anions were studied in electrophysiological experiments on freshly isolated rat ventricular myocytes. Under current‐clamp, action…”
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Electrophysiological Consequences of Purinergic Receptor Stimulation in Isolated Rat Pulmonary Arterial Myocytes by Hartley, S. Anthony, Kozlowski, Roland Z

“…Neither the electrophysiological effects of purinergic receptor stimulation nor the role of ATP in regulating the tone of pulmonary arterial smooth muscle has…”
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An outwardly rectifying anionic background current in atrial myocytes from the human heart by Li, H., Zhang, H., Hancox, J.C., Kozlowski, R.Z.

“…This report describes a hitherto unreported anionic background current from human atrial cardiomyocytes. Under whole-cell patch-clamp with anion-selective…”
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Barbiturates inhibit ATP‐K+ channels and voltage‐activated currents in CRI‐G1 insulin‐secreting cells by Kozlowski, R.Z., Ashford, M.L.J.

“…1 Patch‐clamp recording techniques were used to examine the effects of barbiturates upon the ATP‐K+ channel, and voltage‐activated channels present in the…”
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Functional protein microarrays for parallel characterisation of p53 mutants by Boutell, Jonathan M., Hart, Darren J., Godber, Benjamin L. J., Kozlowski, Roland Z., Blackburn, Jonathan M.

“…Understanding the way in which single nucleotide polymorphisms and mutations in the human genome result in individual susceptibility to disease is a major goal…”
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Nucleotide‐dependent activation of KATP channels by diazoxide in CRI‐G1 insulin‐secreting cells by Kozlowski, R.Z., Ashford, M.L.J.

“…1 Patch‐clamp recording techniques were used, to examine the effects of diazoxide on KATP currents in CRI‐G1 insulin‐secreting cells in the presence of…”
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Modulation of cardiac L‐type Ca2+ channels by GTPγS in response to isoprenaline, forskolin and photoreleased nucleotides by Kozlowski, R.Z., Goodstadt, L.J., Twist, V.W., Powell, T.

“…1 Using the patch‐clamp recording technique, we have investigated the effects of chronic intracellular application of guanosine thiotriphosphate (GTPγS) by…”
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Flash photolysis of intracellular caged GTP gamma S increases L-type Ca2+ currents in cardiac myocytes by Kozlowski, R Z, Twist, V W, Brown, A M, Powell, T

“…L-type calcium currents were recorded from isolated ventricular myocytes using standard patch-clamp methods. Rapid release of photolabile guanosine…”
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Ca(2+)-activated Cl- and K+ channels and their modulation by endothelin-1 in rat pulmonary arterial smooth muscle cells by Salter, K J, Turner, J L, Albarwani, S, Clapp, L H, Kozlowski, R Z

“…Using the patch-clamp recording technique, we observed that endothelin-1 (ET-1; 0.8-16 nM) enhanced a voltage-activated outward current (Iout) and induced…”
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