Complex Analysis of Endothelial Markers as Potential Prognostic Indicators in Luminal Invasive Breast Carcinoma Patients: Outcomes of a Six-Year Observational Study

Complex Analysis of Endothelial Markers as Potential Prognostic Indicators in Luminal Invasive Breast Carcinoma Patients: Outcomes of a Six-Year Observational Study

(1) Background: Metastasis is a complex process in which the primary cancer cells spread to a distant organ or organs, creating a secondary tumor location, which in many patients leads to treatment failure and death. The aim of the present study was to assess the association of endothelial markers (...

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Bibliographic Details
Published in:Biomedicines Vol. 11; no. 8; p. 2246
Main Authors: Kwiatkowska, Katarzyna, Rhone, Piotr, Koziorzemska, Paulina, Formanowicz, Dorota, Ruszkowska-Ciastek, Barbara
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-08-2023
MDPI
Subjects:
Adiponectin
Analysis
Anticoagulants
Apoptosis
Blood platelets
Breast cancer
Breast carcinoma
Cancer therapies
Care and treatment
Cell adhesion & migration
Chemotherapy
Cytokines
Development and progression
Diseases
Endothelium
Estrogens
Immunotherapy
Invasiveness
LAR
Leptin
Leukocytes
Ligands
Mastectomy
Medical prognosis
Medical research
Medicine, Experimental
Metastases
Metastasis
Observational studies
Patient outcomes
Patients
Radiation therapy
Relapse
sE-selectin
sP-selectin
Surgery
Tumor necrosis factor-TNF
Tumors
Von Willebrand factor
Womens health
Poland
Taiwan
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Summary:(1) Background: Metastasis is a complex process in which the primary cancer cells spread to a distant organ or organs, creating a secondary tumor location, which in many patients leads to treatment failure and death. The aim of the present study was to assess the association of endothelial markers (i.e., sP-selectin, sE-selectin and von Willebrand factor) with the leptin-to-adiponectin ratio (LAR) and to perform an analysis of the predictive value on the survival of patients with luminal A and B invasive breast cancer (IBrC). (2) Methods: The trial included 70 treatment-naïve early-stage IBrC patients with a median age of 54.5 years and a median tumor diameter of 1.5 cm. The median duration of follow-up was 5.7 years, with a relapse rate of 15.71%. Specific immunoenzymatic kits were used to determine pre- and post-treatment concentrations of analyzed factors. (3) Results: Regardless of the treatment pattern, endothelial marker concentrations and the LAR increased after adjuvant treatment. The follow-up showed a significantly higher relapse rate in patients with IBrC who had higher pre-treatment sP-selectin and post-treatment LAR levels. According to receiver operating characteristic (ROC) analysis, a post-treatment LAR with a sensitivity of 88.9% and specificity of 57.9% discriminating cases with or without disease relapse. Additionally, a higher risk of breast cancer relapse was associated with a lower post-treatment sP-selectin concentration. (4) Conclusions: Our results showed mainly that pre-treatment sP-selectin levels and post-treatment LAR may have value as prognostic indicators and may contribute to predicting the future outcomes in patients with early-stage IBrC.
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ISSN:2227-9059
2227-9059
DOI:10.3390/biomedicines11082246