Search Results - "Kozin, S. V."

The pH partition theory predicts the accumulation and toxicity of doxorubicin in normal and low-pH-adapted cells by GERWECK, L. E, KOZIN, S. V, STOCKS, S. J

“…The accumulation and toxicity of the weak base doxorubicin has been investigated as a function of extracellular pH, intracellular pH and the cellular pH…”
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Neovascularization after irradiation: what is the source of newly formed vessels in recurring tumors? by Kozin, Sergey V, Duda, Dan G, Munn, Lance L, Jain, Rakesh K

“…Local relapse of tumors after radiation therapy remains a challenge in oncology. To devise rational approaches for preventing this relapse, we have to improve…”
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Cytoprotective and Antioxidant Effects of Meconic Acid in Model Systems by Kozin, S. V., Kravtsov, A. A., Kravchenko, S. V., Ivashchenko, L. I.

“…We studied the antioxidant and cytoprotective effects of meconic acid in the model systems. Meconic acid, similar to commercial drug Mexidol, reduced the…”
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Crystal Structure of Magnesium Comenate by Ivashchenko, L. I., Kozin, S. V., Vasil’eva, L. V., Vasil’ev, A. M., Dotsenko, V. V., Aksenov, N. A., Kravtsov, A. A.

“…The coordination compound [Mg(HCom) 2 (H 2 O) 6 ]·2H 2 O ( I ) was obtained by the reaction of comenic acid (H 2 Com) with magnesium acetate in water. The…”
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Neurotrophic Effect of Magnesium Comenate in Normal and under Conditions of Oxidative Stress in Culture of Chicken Spinal Ganglia by Shurygina, L. V., Zlishcheva, E. I., Kravtsov, A. A., Kozin, S. V.

“…The neurotrophic properties of magnesium comenate were studied under standard conditions and under conditions of oxidative stress. It was found that magnesium…”
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Changes in Free Radical Processes under the Influence of Low-Frequency Electromagnetic Field in Rats by Tekutskaya, E. E., Ryabova, I. S., Kozin, S. V., Popov, K. A., Malyshko, V. V.

“…We studied the effect of a low-frequency (LF) electromagnetic field (EMF) on the state of the antioxidant system of Wistar rats in vivo . It was found that…”
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Changes in Prooxidant-Antioxidant System Indices in the Blood and Brain of Rats with Modelled Acute Hypoxia which Consumed a Deuterium-Depleted Drinking Diet by Basov, A. A., Kozin, S. V., Bikov, I. M., Popov, K. A., Moiseev, A. V., Elkina, A. A., Dzhimak, S. S.

“…— Using the rat hypoxia model, the imbalanced work of antiradical defense enzymes with insufficient dismutase activity in blood leading to the development of…”
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Cytotoxicity of weak electrolytes after the adaptation of cells to low pH: role of the transmembrane pH gradient by KOZIN, S. V, GERWECK, L. E

“…Theory suggests that the transmembrane pH gradient may be a major determinant of the distribution of lipophilic weak electrolytes across the cell membrane. The…”
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Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer by Willett, Christopher G, Jain, Rakesh K, Boucher, Yves, di Tomaso, Emmanuelle, Duda, Dan G, Munn, Lance L, Tong, Ricky T, Chung, Daniel C, Sahani, Dushyant V, Kalva, Sanjeeva P, Kozin, Sergey V, Mino, Mari, Cohen, Kenneth S, Scadden, David T, Hartford, Alan C, Fischman, Alan J, Clark, Jeffrey W, Ryan, David P, Zhu, Andrew X, Blaszkowsky, Lawrence S, Chen, Helen X, Shellito, Paul C, Lauwers, Gregory Y

“…The effects of vascular endothelial growth factor (VEGF) blockade on the vascular biology of human tumors are not known. Here we show here that a single…”
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The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis by Garkavtsev, Igor, Kozin, Sergey V, Chernova, Olga, Xu, Lei, Winkler, Frank, Brown, Edward, Barnett, Gene H, Jain, Rakesh K

“…Gliomas are the most common primary tumours of the central nervous system, with nearly 15,000 diagnosed annually in the United States and a lethality…”
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DEVELOPMENT OF NITROFURAN DERIVATIVE: COMPOSITION AND TECHNOLOGY OF EFFERVESCENT TABLETS WITH SOLID DISPERSIONS by Elagina, A. O., Belyatskaya, A. V., Krasnyuk (Jr.), I. I., Krasnyuk, I. I., Stepanova, O. I., Fateeva, T. V., Smolyarchuk, E. A., Kozin, S. V., Plakhotnaya, O. N., Rаstopchina, O. V., Rau, J. V.

“…Taking into account the current Product specification file, the aim of the work was to develop the composition and technology for obtaining effervescent…”
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Immunohistochemical assay of murine liver tissue using monoclonal antibodies to NO-synthase 2 and TNF-α under tetrachloromethane toxic injury conditions by Pechenkina, I G, Kozin, S V, Bulanov, D V

“…Experimental data showing a significant role of enzyme NO-synthase type 2 and cytokine TNF-α enzymes in pathogenesis of CCl4-induced liver injury have been…”
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Vascular endothelial growth factor receptor-2-blocking antibody potentiates radiation-induced long-term control of human tumor xenografts by KOZIN, Sergey V, BOUCHER, Yves, HICKLIN, Daniel J, BOHLEN, Peter, JAIN, Rakesh K, SUIT, Herman D

“…Antiangiogenic therapy can enhance radiation-induced tumor growth inhibition. However, the effects of combined antiangiogenic and radiation therapy on…”
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Relative biological effectiveness of proton beams in clinical therapy by Gerweck, Leo E., Kozin, Sergey V.

“…Purpose: In clinical proton beam radiation therapy, an RBE of 1.1 relative to megavoltage X-rays is currently being employed at most treatment centers. This…”
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The cell transmembrane pH gradient in tumors enhances cytotoxicity of specific weak acid chemotherapeutics by KOZIN, Sergey V, SHKARIN, Pavel, GERWECK, Leo E

“…The extracellular pH is lower in tumor than in normal tissue, whereas their intracellular pH is similar. In this study, we show that the tumor-specific pH…”
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Thermoradiotherapy with Hydralazine: The Effect of Preirradiation of the Tumor Bed on Blood Flow and Growth Delay of Ehrlich Carcinoma by Kozin, Sergey V., Kozina, Ludmila V.

“…Ehrlich carcinoma transplanted into preirradiated calf muscle of mice was used as a model for tumor recurrence after unsuccessful radiotherapy. Due to the…”
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Antitumour effect of irradiation followed by hyperglycemia and hyperthermia: the dependence on tumour size and blood flow by Kozin, S V, Zaitsev, A V, Yarmonenko, S P

“…The interrelationship of three tumour parameters-volume, blood flow and growth delay-was evaluated after irradiation alone or combined with hyperglycemia (HG)…”
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Shift of Prooxidant–Antioxidant Balance in Laboratory Animals at Five Times Higher Deuterium Content in Drinking Water by Kozin, S. V., Lyasota, O. M., Kravtsov, A. A., Chikhirzhina, E. V., Ivlev, V. A., Popov, K. A., Dorohova, A. A., Malyshko, V. V., Moiseev, A. V., Drozdov, A. V., Dzhimak, S. S.

“…Water containing 750 ppm deuterium was used to simulate the isotopic composition of water in ice caps at the poles of Mars and tested for effect on oxidative…”
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Meconic Acid Is a Possible Neuroprotector: Justification Based on in vitro Experiments and Its Physicochemical Properties by Kozin, S. V., Ivashchenko, L. I., Kravtsov, A. A., Vasilyeva, L. V., Vasiliev, A. M., Bukov, N. N., Dorohova, A. A., Lyasota, O. M., Bespalov, A. V., Dzhimak, S. S.

“…Meconic, comenic, chelidonic, and kojic acids are the main representatives of gamma-pyronic acids. It was found that comenic acid has a neuroprotective effect,…”
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The use of a hypoxic cell radiosensitizer AK-2123 gave no improvement in thermoradiotherapy combined with hydralazine by Kozin, S V, Hasegawa, T, Kozina, L V, Imamura, M, Akagi, K, Tanaka, Y, Kagiya, V T

“…An electron-affinic compound, AK-2123, and the anti-hypertensive agent, hydralazine, were combined with radiation and hyperthermia for treatment of murine…”
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