Search Results - "Kozakai, Sao"

Impaired antigen‐specific lymphocyte priming in mice after Toll‐like receptor 4 activation via induction of monocytic myeloid‐derived suppressor cells by Tsukamoto, Hiroki, Kozakai, Sao, Kobayashi, Yohei, Takanashi, Risako, Aoyagi, Takuya, Numasaki, Muneo, Ohta, Shoichiro, Tomioka, Yoshihisa

“…In sepsis, the pathology involves a shift from a proinflammatory state toward an immunosuppressive phase. We previously showed that an agonistic anti‐TLR4…”
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Leucine-rich repeat 2 of human Toll-like receptor 4 contains the binding site for inhibitory monoclonal antibodies by Tsukamoto, Hiroki, Ukai, Ippo, Yamagata, Yuki, Takeuchi, Shino, Kubota, Kanae, Kozakai, Sao, Suzuki, Naoto, Kimoto, Masao, Tomioka, Yoshihisa

“…•A novel anti-TLR4 mAb HTB2 was obtained by cross-block screening against HT52.•HTB2 inhibits LPS-induced TLR4 activation.•HT52 and HTB2 epitopes were…”
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An inhibitory epitope of human Toll‐like receptor 4 resides on leucine‐rich repeat 13 and is recognized by a monoclonal antibody by Tsukamoto, Hiroki, Yamagata, Yuki, Ukai, Ippo, Takeuchi, Shino, Okubo, Misaki, Kobayashi, Yohei, Kozakai, Sao, Kubota, Kanae, Mumasaki, Muneo, Kanemitsu, Yoshitomi, Matsumoto, Yotaro, Tomioka, Yoshihisa

“…Lipopolysaccharide (LPS)‐induced activation of Toll‐like receptor 4 (TLR4) elicits the innate immune response and can trigger septic shock if excessive. Two…”
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An inhibitory epitope of human Toll‐like receptor 4 resides on leucine‐rich repeat 13 and is recognized by a monoclonal antibody by Tsukamoto, Hiroki, Yamagata, Yuki, Ukai, Ippo, Takeuchi, Shino, Okubo, Misaki, Kobayashi, Yohei, Kozakai, Sao, Kubota, Kanae, Numasaki, Muneo, Kanemitsu, Yoshitomi, Matsumoto, Yotaro, Tomioka, Yoshihisa

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Lipopolysaccharide (LPS)-binding protein stimulates CD14-dependent Toll-like receptor 4 internalization and LPS-induced TBK1–IKKϵ–IRF3 axis activation by Tsukamoto, Hiroki, Takeuchi, Shino, Kubota, Kanae, Kobayashi, Yohei, Kozakai, Sao, Ukai, Ippo, Shichiku, Ayumi, Okubo, Misaki, Numasaki, Muneo, Kanemitsu, Yoshitomi, Matsumoto, Yotaro, Nochi, Tomonori, Watanabe, Kouichi, Aso, Hisashi, Tomioka, Yoshihisa

“…Toll-like receptor 4 (TLR4) is an indispensable immune receptor for lipopolysaccharide (LPS), a major component of the Gram-negative bacterial cell wall…”
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