Search Results - "Kozak, Leslie"

Brown Fat and the Myth of Diet-Induced Thermogenesis by Kozak, Leslie P.

“…The notion that brown adipose tissue (BAT) in mice or humans maintains energy balance by burning off excess calories seems incompatible with evolutionary…”
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Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure by Ziętak, Marika, Kovatcheva-Datchary, Petia, Markiewicz, Lidia H., Ståhlman, Marcus, Kozak, Leslie P., Bäckhed, Fredrik

“…Maintenance of body temperature in cold-exposed animals requires induction of thermogenesis and management of fuel. Here, we demonstrated that reducing ambient…”
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Bile acids induce uncoupling protein 1-dependent thermogenesis and stimulate energy expenditure at thermoneutrality in mice by Zietak, Marika, Kozak, Leslie P

“…It has been proposed that diet-induced obesity at thermoneutrality (TN; 29°C) is reduced by a UCP1-dependent thermogenesis; however, it has not been shown how…”
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A Recurring Problem With the Analysis of Energy Expenditure in Genetic Models Expressing Lean and Obese Phenotypes by BUTLER, Andrew A, KOZAK, Leslie P

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Mitochondrial turnover: a phenotype distinguishing brown adipocytes from interscapular brown adipose tissue and white adipose tissue by Gospodarska, Emilia, Nowialis, Pawel, Kozak, Leslie P

“…To determine the differences between brown adipocytes from interscapular brown tissue (iBAT) and those induced in white adipose tissue (WAT) with respect to…”
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Uncoupling Protein 1 and Sarcolipin Are Required to Maintain Optimal Thermogenesis, and Loss of Both Systems Compromises Survival of Mice under Cold Stress by Rowland, Leslie A., Bal, Naresh C., Kozak, Leslie P., Periasamy, Muthu

“…The importance of brown adipose tissue as a site of nonshivering thermogenesis has been well documented. Emerging studies suggest that skeletal muscle is also…”
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Npvf: Hypothalamic Biomarker of Ambient Temperature Independent of Nutritional Status by Jaroslawska, Julia, Chabowska-Kita, Agnieszka, Kaczmarek, Monika M, Kozak, Leslie P

“…The mechanism by which mice, exposed to the cold, mobilize endogenous or exogenous fuel sources for heat production is unknown. To address this issue we…”
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Changes in gene expression foreshadow diet-induced obesity in genetically identical mice by Koza, Robert A, Nikonova, Larissa, Hogan, Jessica, Rim, Jong-Seop, Mendoza, Tamra, Faulk, Christopher, Skaf, Jihad, Kozak, Leslie P

“…High phenotypic variation in diet-induced obesity in male C57BL/6J inbred mice suggests a molecular model to investigate non-genetic mechanisms of obesity…”
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Obesity and related consequences to ageing by Jura, Magdalena, Kozak, Leslie.P.

“…Obesity has become a major public health problem. Given the current increase in life expectancy, the prevalence of obesity also raises steadily among older age…”
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Isolation and identification of endogenous RFamide‐related peptides 1 and 3 in the mouse hypothalamus by Gospodarska, Emilia, Kozak, Leslie P., Jaroslawska, Julia

“…Although the RFamide‐related peptide (RFRP) preproprotein sequence is known in mice, until now, the molecular structure of the mature, functional peptides…”
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Mest and Sfrp5 are biomarkers for healthy adipose tissue by Jura, Magdalena, Jarosławska, Julia, Chu, Dinh Toi, Kozak, Leslie P.

“…Obesity depends on a close interplay between genetic and environmental factors. However, it is unknown how these factors interact to cause changes in the obese…”
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Diet-induced adipose tissue expansion is mitigated in mice with a targeted inactivation of mesoderm specific transcript (Mest) by Anunciado-Koza, Rea P, Manuel, Justin, Mynatt, Randall L, Zhang, Jingying, Kozak, Leslie P, Koza, Robert A

“…Interindividual variation of white adipose tissue (WAT) expression of mesoderm specific transcript (Mest), a paternally-expressed imprinted gene belonging to…”
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Genetic variation in brown fat activity and body weight regulation in mice: Lessons for human studies by Kozak, Leslie P.

“…The recent characterization of brown fat in humans has generated much excitement on the possibility that increased energy expenditure by heat production by…”
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The critical period for brown adipocyte development: Genetic and environmental influences by Chabowska‐Kita, Agnieszka, Kozak, Leslie P.

“…Objective The current review summarizes recent advances in the origin of brown adipocytes in rodents and humans. Methods This review describes recent insights…”
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Expression of Adipocyte Biomarkers in a Primary Cell Culture Models Reflects Preweaning Adipobiology by Chu, Dinh-Toi, Malinowska, Elzbieta, Gawronska-Kozak, Barbara, Kozak, Leslie P.

“…A cohort of genes was selected to characterize the adipogenic phenotype in primary cell cultures from three tissue sources. We compared the quantitative…”
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The early nutritional environment of mice determines the capacity for adipose tissue expansion by modulating genes of caveolae structure by Kozak, Leslie P, Newman, Susan, Chao, Pei-Min, Mendoza, Tamra, Koza, Robert A

“…While the phenomenon linking the early nutritional environment to disease susceptibility exists in many mammalian species, the underlying mechanisms are…”
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C57BL/6J mice as a polygenic developmental model of diet‐induced obesity by Chu, Dinh‐Toi, Malinowska, Elzbieta, Jura, Magdalena, Kozak, Leslie P.

“…Susceptibility to obesity changes during the course of life. We utilized the C57BL/6J (B6) and 129S mouse as a genetic model for variation in diet‐induced…”
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Inactivation of UCP1 and the Glycerol Phosphate Cycle Synergistically Increases Energy Expenditure to Resist Diet-induced Obesity by Anunciado-Koza, Rea, Ukropec, Jozef, Koza, Robert A., Kozak, Leslie P.

“…Our current paradigm for obesity assumes that reduced thermogenic capacity increases susceptibility to obesity, whereas enhanced thermogenic capacity protects…”
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Neotenic phenomenon in gene expression in the skin of Foxn1- deficient (nude) mice - a projection for regenerative skin wound healing by Kur-Piotrowska, Anna, Kopcewicz, Marta, Kozak, Leslie P, Sachadyn, Pawel, Grabowska, Anna, Gawronska-Kozak, Barbara

“…Mouse fetuses up to 16 day of embryonic development and nude (Foxn1- deficient) mice are examples of animals that undergo regenerative (scar-free) skin…”
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Genetic variability affects the development of brown adipocytes in white fat but not in interscapular brown fat by Xue, Bingzhong, Rim, Jong-Seop, Hogan, Jessica C, Coulter, Ann A, Koza, Robert A, Kozak, Leslie P

“…Cold exposure induces brown adipocytes in retroperitoneal fat (RP) of adult A/J mice but not in C57BL/6J (B6) mice. In contrast, induction of the mitochondrial…”
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