Search Results - "Kozai, Shigetada"

Synthesis and Anti-HIV-1 and Anti-HCMV Activity of 1-Substituted 3-(3,5-Dimethylbenzyl)uracil Derivatives by Maruyama, Tokumi, Kozai, Shigetada, Demizu, Yosuke, Witvrouw, Myriam, Pannecouque, Christophe, Balzarini, Jan, Snoecks, Robert, Andrei, Graciella, Clercq, Erik De

“…3-(3,5-Dimethylbenzyl)uracil (3) was treated with alkyl halides in the presence of alkali to give 1-substituted congeners. Condensation of 3 with alcohols…”
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Synthesis and Antiviral Activity of 1,3-Disubstituted Uracils against HIV-1 and HCMV by Maruyama, Tokumi, Kozai, Shigetada, Yamasaki, Tetsuo, Witvrouw, Myriam, Pannecouque, Christophe, Balzarini, Jan, Snoeck, Robert, Andrei, Graciella, De Clercq, Erik

“…The development of new non-nucleoside reverse transcriptase inhibitors (NNRTIs) is an efficient strategy for finding new therapeutic agents against human…”
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Synthesis of 9-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)adenine bearing a selectively removable protecting group by MARUYAMA, T, TAKAMATSU, S, KOZAI, S, SATOH, Y, IZAWA, K

“…A facile and practical method to introduce fluorine at the up-side of the 2'-carbon of nucleosides is described. 6-Chloropurine riboside 3 was converted to the…”
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Synthesis and Biological Activity of 9-(2, 6-Difluorobenzyl)-9H-purines Bearing Chlorine by KOZAI, Shigetada, MARUYAMA, Tokumi

“…Mitsunobu reaction of 2, 6-dichloropurine with 2, 6-difluorobenzyl alcohol gave 2, 6-dichloro-9-(2, 6-difluorobenzyl)-9H-purine and 7-benzylated congener in…”
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Synthesis and Hypnotic Activities of 4-Thio Analogues of N3-Substituted Uridines by KOZAI, Shigetada, MARUYAMA, Tokumi, KIMURA, Toshiyuki, YAMAMOTO, Ikuo

“…Reaction of tri-O-acetyluridine (1) with benzyl bromide or 2-chloroacetophenone in the presence of K2CO3 gave the N3-substituted analogues 2a, c. Condensation…”
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Introduction of a benzoyl group onto riboside in aqueous solution: One-step synthesis of 6-chloropurine 2′,3′-di- O-benzoylriboside by Kozai, Shigetada, Takamatsu, Satoshi, Izawa, Kunisuke, Maruyama, Tokumi

“…A benzoyl group was introduced onto the 3′-hydroxyl group of 6-chloropurine riboside by treatment with benzoylating agents in the presence of an organic or…”
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Reaction of N3-benzyluracil and N-hydroxymethylphthalimide with the Mitsunobu reagent: synthesis of hydrazylmethyluracils by Kozai, Shigetada, Takaoka, Shigeru, Maruyama, Tokumi

“…N 3-Benzyluracil was treated with N-hydroxymethylphthalimide in the presence of the Mitsunobu reagent to give an unusual product bearing a hydrazylmethyl group…”
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Reaction of 7-(2-Mesyloxy-2-phenylethyl)theophylline with Amines: Synthesis of 1,2,3,6-Tetrahydro-6-imino-2-oxo-7 H -purine Derivatives by Kozai, Shigetada, Ogimoto, Kyoko, Maruyama, Tokumi

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Antiviral Activity of 3-(3,5-Dimethylbenzyl)Uracil Derivatives Against Hiv-1 and HCMV by Maruyama, Tokumi, Demizu, Yosuke, Kozai, Shigetada, Witvrouw, Myriam, Pannecouque, Christophe, Balzarini, Jan, Snoecks, Robert, Andrei, Graciella, De Clercq, Erik

“…Antiviral activity of 1,3-disubstituted uracil derivatives was evaluated against HIV-1 and HCMV. It appears that the nitrogen of the 1-cyanomethyl group is…”
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Introduction of a Benzyl Group onto the 2′-OH of 6-Chloropurine 3′-O-Benzoylriboside by Kozai, Shigetada, Fuzikawa, Tomoyo, Harumoto, Keisuke, Maruyama, Tokumi

“…A new method to introduce a benzyl group onto the 2′-OH of purine ribonucleoside is described. Thus, 6-chloropurine 3′-O-benzoylriboside and its 5′-O-trityl…”
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A New Method for the Synthesis of 2′-O-Benzyladenosine Using Mitsunobu Reaction by Kozai, Shigetada, Fuzikawa, Tomoyo, Harumoto, Keisuke, Maruyama, Tokumi

“…A new method to introduce a benzyl group onto the 2′-OH of purine ribonucleoside is described. Thus, 6-chloropurine 3′-O-benzoylriboside and its 5′-O-trityl…”
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SYNTHESIS of 2′-DEOXY-2′-FLUOROGUANYL-(3′,5′)-GUANOSINE by Maruyama, Tokumi, Kozai, Shigetada, Nakamura, Kazuo, Irie, Masachika

“…The protected analogue of 2-amnio-6-chloropurine arabinoside (3b) was subjected to reaction with diethylaminosulfur trifluoride (DAST) and subsequently treated…”
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Synthesis of 9-(2-Deoxy-2-fluoro-β-D-arabinofuranosyl)adenine Bearing a Slectively Removable Protecting Group by MARUYAMA, Tokumi, TAKAMATSU, Satoshi, KOZAI, Shigetada, SATOH, Yoshiko, IZAWA, Kunisuke

“…A facile and practicam method to infroduce fluorine at the up-side of the 2'-carbon of nucleosides is described. 6-Chloropurine riboside 3 was converted to the…”
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A NEW METHOD FOR THE SYNTHESIS OF N 2-ALKYLGUANOSINES USING MITSUNOBU REACTION AS A KEY STEP by Kozai, Shigetada, Yorikane, Aya, Maruyama, Tokumi

“…Peracetylated guanosine was reacted with POCl 3 to give an 2-acetamido-6-chloro-9H-purine derivative, which was condensed with primary or secondary alcohols to…”
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SYNTHESIS OF N 2-ALKYLGUANOSINE USING MITSUNOBU REACTION AS A KEY STEP by Maruyama, Tokumi, Yorikane, Aya, Kozai, Shigetada

“…Peracetylated guanosine was reacted with POCl 3 to give an 2-acetamido-6- chloro-9H-purine derivative, which was condensed with primary or secondary alcohols…”
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Method for the Synthesis of Uric Acid Derivatives by Maruyama, Tokumi, Kozai, Shigetada, Sasaki, Fumi

“…A general procedure to obtain tetra-substituted uric acid by stepwise N-alkylation is described. 2,6-Dichloropurine (1) was condensed with 1-propanol by…”
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Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1 by Maruyama, Tokumi, Kozai, Shigetada, Demizu, Yosuke, Witvrouw, Myriam, Pannecouque, Christophe, Balzarini, Jan, Snoeck, Robert, Andrei, Graciella, De Clercq, Erik

“…1,3-disubstituted uracils were obtained from uracil by the stepwise alkylation at N-1 and N-3 position with alkyl halide/alkali or alcohol under Mitsunobu…”
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Synthesis and antiviral activity of 1-substituted 3-(3,5-dimethylbenzyl)uracil against HIV-1 by Maruyama, Tokumi, Kozai, Shigetada, Demizu, Yosuke, Witvrouw, Myriam, Pannecouque, Christophe, Balzarini, Jan, Snoeck, Robert, Andrei, Graciella, De Clercq, Erik

“…1,3-Disubstituted uracils were obtained from uracil by the stepwise alkylation at N-1 and N-3 position with alkyl halide/alkali or alcohol under Mitsunobu…”
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Reaction of 7-(2-mesyloxy-2-phenylethyl)theophylline with amines: Synthesis of 1,2,3,6-tetrahydro-6-imino-2-oxo-7H-purine derivatives by Kozai, Shigetada, Ogimoto, Kyoko, Okamoto, Hideko, Maruyama, Tokumi

“…Theophylline was converted to 7-(2-phenyl-2-methanesulfonyloxy)ethyl congener and the product was treated with ammonia or primary amines in a mixture solution…”
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Synthesis and hypnotic-sedative activities of N-substituted uracil on mice by Maruyama, Tokumi, Kozai, Shigetada, Shimizu, Tomomi, Kimura, Toshiyuki, Watanabe, Kazuhito, Yamamoto, lkuo

“…N3-Phenacyl-N1-substituted uracils 3a-q were synthesized by introduction of substituents at the N1-position of 9-phenacyluracil 2, and their hypnotic and…”
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