Search Results - "Koyuki Tajima"

A comparison of vasodilation mode among selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N-(methylsulfonyl)acetamide]), its active metabolite MRE-269 and various prostacyclin receptor agonists in rat, porcine and human pulmonary arteries by Fuchikami, Chiaki, Murakami, Kohji, Tajima, Koyuki, Homan, Junko, Kosugi, Keiji, Kuramoto, Kazuya, Oka, Michiko, Kuwano, Keiichi

“…Selexipag (NS-304; [2-{4-[(5,6-diphenylpyrazin-2-yl)(isopropyl)amino]butoxy}-N- (methylsulfonyl)acetamide]) is a novel, orally available non-prostanoid…”
Get full text

Irsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats by Zhang, Xin, Tajima, Koyuki, Kageyama, Kiyoto, Kyoi, Takashi

“…To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by indomethacin…”
Get full text

Etodolac, a cyclooxygenase-2 inhibitor, attenuates paclitaxel-induced peripheral neuropathy in a mouse model of mechanical allodynia by Ito, Sunao, Tajima, Koyuki, Nogawa, Masaki, Inoue, Naoki, Kyoi, Takashi, Takahashi, Yosuke, Sasagawa, Takahiro, Nakamura, Akio, Kotera, Takashi, Ueda, Makoto, Yamashita, Yasuhiro, Banno, Kouji

“…The effect of the cyclooxygenase-2 (COX-2) inhibitor etodolac on the mechanical allodynia induced by paclitaxel was investigated in mice and compared with the…”
Get more information

The Enantiomers of Etodolac, a Racemic Anti-inflammatory Agent, Play Different Roles in Efficacy and Gastrointestinal Safety by Inoue, Naoki, Nogawa, Masaki, Ito, Sunao, Tajima, Koyuki, Kume, Sato, Kyoi, Takashi

“…The anti-inflammatory agent etodolac is used worldwide and it has a good gastrointestinal safety profile. Etodolac consists of two enantiomers, S- and…”
Get full text

Etodolac Attenuates Mechanical Allodynia in a Mouse Model of Neuropathic Pain by Inoue, Naoki, Ito, Sunao, Tajima, Koyuki, Nogawa, Masaki, Takahashi, Yosuke, Sasagawa, Takahiro, Nakamura, Akio, Kyoi, Takashi

“…Cyclooxygenase (COX) contributes to neuropathic pain after peripheral nerve injury, yet COX inhibitors are generally ineffective against mechanical allodynia…”
Get full text

Etodolac blocks the allyl isothiocyanate-induced response in mouse sensory neurons by selective TRPA1 activation by Inoue, Naoki, Ito, Sunao, Nogawa, Masaki, Tajima, Koyuki, Kyoi, Takashi

“…The excitability of nociceptors is modulated by the transient receptor potential cation channel, ankyrin subfamily, member 1 (TRPA1). We have previously…”
Get more information

Phosphodiesterase Type IV Inhibitors Prevent Ischemia-Reperfusion-Induced Gastric Injury in Rats by Kyoi, Takashi, Kitazawa, Satoru, Tajima, Koyuki, Zhang, Xin, Ukai, Yojiro

“…The effects of selective inhibitors of phosphodiesterase type IV (PDE4) on ischemia-reperfusion-induced gastric injuries were investigated in rats. Gastric…”
Get full text

P1I-86 Analgesic effect of etodolac, a selective cyclooxygenase-2 inhibitor, on partial sciatic nerve ligation-induced allodynia in mice by Sunao Ito, Koyuki Tajima, Masaki Nogawa, Naoki Inoue, Takashi Kyoi, Kenji Kuwabara

Get full text

Safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension: Japanese post-marketing surveillance data by Yamazaki, Hiroyoshi, Kobayashi, Noriko, Taketsuna, Masanori, Tajima, Koyuki, Murakami, Masahiro

“…Objective: To evaluate the long-term safety and effectiveness of tadalafil in patients with pulmonary arterial hypertension (PAH) in real-world clinical…”
Get full text

Safety and effectiveness of tadalafil in pediatric patients with pulmonary arterial hypertension: a sub-group analysis based on Japan post-marketing surveillance by Yamazaki, Hiroyoshi, Kobayashi, Noriko, Taketsuna, Masanori, Tajima, Koyuki, Suzuki, Nahoko, Murakami, Masahiro

“…Objective: To evaluate the long-term safety and effectiveness of tadalafil in pediatric patients with pulmonary arterial hypertension (PAH) in real-world…”
Get full text

Anti-ulcer drug irsogladine prevents ischemia-reperfusion-induced gastric mucosal injury in rats by Satoru Kitazawa, Koyuki Tajima, Xin Zhang, Takashi Kyoi

Get full text

Real-World Safety and Effectiveness of Tadalafil in Patients with Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia: A Japanese Post-Marketing Surveillance Study by Yamazaki, Hiroyoshi, Tsujimoto, Naoto, Koyanagi, Momoha, Katoh, Megumi C, Tajima, Koyuki, Komori, Mika

“…To evaluate the long-term safety and effectiveness of tadalafil in Japanese men with lower urinary tract symptoms secondary to benign prostatic hyperplasia in…”
Get full text

Blockade of voltage-gated calcium channel Cav1.2 and α1-adrenoceptors increases vertebral artery blood flow induced by the antivertigo agent difenidol by Murakami, Kohji, Inoue, Naoki, Fuchikami, Chiaki, Tajima, Koyuki, Hashino, Asami, Fukui, Hisashi, Noda, Kumiko, Oka, Michiko

“…Difenidol (1,1-diphenyl-4-piperidino-1-butanol hydrochloride) is an effective drug for the treatment of vertigo and dizziness. This drug is known to improve…”
Get full text

Zrsogladine maleate suppresses indomethacin-induced elevation of proinflammatory cytokines and gastric injury in rats by Xin Zhang Koyuki Tajima Kiyoto Kageyama Takashi Kyoi

“…AIM： To investigate the mucosal protective effect and the mechanisms of action of the anti-ulcer drug irsogladine maleate in gastric injury induced by…”
Get full text

Phosphodiesterase Type IV Inhibitors Prevent Ischemia-Reperfusion-Induced Gastric Injury in Rats by Takashi Kyoi, Satoru Kitazawa, Koyuki Tajima, Xin Zhang, Yojiro Ukai

“…The effects of selective inhibitors of phosphodiesterase type IV (PDE4) on ischemia-reperfusion-induced gastric injuries were investigated in rats. Gastric…”
Get full text

Effect of YNS-15P, a new alpha-2 adrenoceptor antagonist, on stress-stimulated colonic propulsion in rats by Yamamoto, O, Niida, H, Tajima, K, Shirouchi, Y, Kyotani, Y, Ueda, F, Kise, M, Kimura, K

“…We studied effects of a novel alpha-2 adrenoceptor antagonist, YNS-15P (N-[(2R,11bS)-9-methoxy-1,3,4,6,7,…”
Get more information