Search Results - "Koynova, Rumiana"

An Intracellular Lamellar-Nonlamellar Phase Transition Rationalizes the Superior Performance of Some Cationic Lipid Transfection Agents by Koynova, Rumiana, Wang, Li, MacDonald, Robert C.

“…Two cationic phospholipid derivatives with asymmetric hydrocarbon chains were synthesized: ethyl esters of oleoyldecanoylethylphosphatidylcholine…”
Get full text

Recent Progress in Liposome Production, Relevance to Drug Delivery and Nanomedicine by Koynova, Rumiana, Tenchov, Boris

“…From their discovery half a century ago and the subsequent appreciation of their clinical utility, liposomes currently hold a recognized position in the…”
Get more information

Exothermic transitions in the heat capacity profiles of human cerebrospinal fluid by Antonova, Borislava, Naydenov, Emanuil, Koynova, Rumiana, Tumangelova-Yuzeir, Kalina, Tenchov, Boris

“…In this work, we examined by DSC protein denaturation heat capacity profiles for two body fluids, cerebrospinal fluid (CSF) and blood plasma obtained from…”
Get full text

Phases and phase transitions of the phosphatidylcholines by Koynova, Rumiana, Caffrey, Martin

“…LIPIDAT (http://www.lipidat.chemistry.ohio-state.edu) is an Internet accessible, computerized relational database providing access to the wealth of information…”
Get full text

Enhancing nucleic acid delivery, insights from the cationic phospholipid carriers by Koynova, Rumiana, Tenchov, Boris

“…The development of nucleic acid-based drugs has attracted considerable interest in the past two decades as a new category of biologics. A key challenge in…”
Get more information

Calorimetric monitoring data of the evolution of the lamellar-inverted hexagonal phase transition in phosphatidylethanolamine dispersions upon temperature cycling by Koynova, Rumiana, Tenchov, Boris

“…The data presented in this article are related to the research article entitled "Cubic phases in phosphatidylethanolamine dispersions: formation, stability and…”
Get full text

Preparation, biodistribution and neurotoxicity of liposomal cisplatin following convection enhanced delivery in normal and F98 glioma bearing rats by Huo, Tianyao, Barth, Rolf F, Yang, Weilian, Nakkula, Robin J, Koynova, Rumiana, Tenchov, Boris, Chaudhury, Abhik Ray, Agius, Lawrence, Boulikas, Teni, Elleaume, Helene, Lee, Robert J

“…The purpose of this study was to evaluate two novel liposomal formulations of cisplatin as potential therapeutic agents for treatment of the F98 rat glioma…”
Get full text

Lipoplex formulation of superior efficacy exhibits high surface activity and fusogenicity, and readily releases DNA by Koynova, Rumiana, Tarahovsky, Yury S., Wang, Li, MacDonald, Robert C.

“…Lipoplexes containing a mixture of cationic phospholipids dioleoylethylphosphatidylcholine (EDOPC) and dilauroylethylphosphatidylcholine (EDLPC) are known to…”
Get full text

Nonlamellar Phases in Cationic Phospholipids, Relevance to Drug and Gene Delivery by Koynova, Rumiana, Tenchov, Boris, MacDonald, Robert C

“…Lipid aggregates have been used as drug carriers for several decades. Recently, nonlamellar liquid crystalline lipid systems have attracted attention as…”
Get full text

Cationic Phospholipids Forming Cubic Phases: Lipoplex Structure and Transfection Efficiency by Koynova, Rumiana, Wang, Li, MacDonald, Robert C

“…The transfection activity and the phase behavior of two novel cationic O-alkyl-phosphatidylcholines, 1,2-dioleoyl-sn-glycero-3-hexylphosphocholine (C6-DOPC)…”
Get full text

Synergy in Lipofection by Cationic Lipid Mixtures:  Superior Activity at the Gel−Liquid Crystalline Phase Transition by Koynova, Rumiana, Wang, Li, MacDonald, Robert C

“…Some mixtures of two cationic lipids including phospholipid compounds (O-ethylphosphatidylcholines) as well as common, commercially available cationic lipids,…”
Get full text

Accelerated Formation of Cubic Phases in Phosphatidylethanolamine Dispersions by Tenchov, Boris, Koynova, Rumiana, Rapp, Gert

“…By means of x-ray diffraction we show that several sodium salts and the disaccharides sucrose and trehalose strongly accelerate the formation of cubic phases…”
Get full text

Cubic phases in phosphatidylethanolamine dispersions: Formation, stability and phase transitions by Tenchov, Boris, Koynova, Rumiana

“…[Display omitted] •Phosphatidylethanolamine dispersions form stable Im3m and Pn3m cubic phases by temperature cycling through Lα-HII transition.•The Im3m phase…”
Get full text

Phases and phase transitions of the hydrated phosphatidylethanolamines by Koynova, R, Caffrey, M

“…LIPIDAT is a computerized database providing access to the wealth of information scattered throughout the literature concerning synthetic and biologically…”
Get more information

Cubic phases in phosphatidylethanolamine dispersions: Formation, stability and phase transitions by Tenchov, Boris, Koynova, Rumiana

Get full text

Thermal stability of calf skin collagen type I in salt solutions by Komsa-Penkova, Regina, Koynova, Rumiana, Kostov, Georgi, Tenchov, Boris G.

“…The thermal stability of acid-soluble collagen type I from calf skin in salt solutions is studied by high-sensitivity differential scanning calorimetry. Three…”
Get full text

Cubic phases in membrane lipids by Tenchov, Boris, Koynova, Rumiana

“…On the basis of data obtained by time-resolved X-ray diffraction, we consider in the present article the occurrence and formation pathways of inverted…”
Get full text

A novel DSC approach for evaluating protectant drugs efficacy against dementia by Abarova, Silviya, Koynova, Rumiana, Tancheva, Lyubka, Tenchov, Boris

“…Differential scanning calorimetry was applied to evaluate the efficacy of preventive treatments with biologically active compounds of plant origin against…”
Get full text

Beneficial effect of sequential chemotherapy treatments of lung cancer patients revealed by calorimetric monitoring of blood plasma proteome denaturation by Koynova, Rumiana, Antonova, Borislava, Sezanova, Boryana, Tenchov, Boris

“…•Heat capacity profiles of blood plasma from lung cancer patients differ from those of healthy controls.•Chemotherapy shifts the parameters of blood plasma…”
Get full text

Low-temperature exothermic transitions in brain proteome of mice, effect of scopolamine by Tenchov, Boris, Abarova, Silviya, Koynova, Rumiana, Traikov, Lubomir, Tancheva, Lyubka

“…•A low-temperature exothermic event takes place in brain supernatants of healthy mice.•It may reflect a process of aggregation of water-soluble protein…”
Get full text