Search Results - "Kowluru, A."

Long Noncoding RNA MALAT1 and Regulation of the Antioxidant Defense System in Diabetic Retinopathy by Radhakrishnan, Rakesh, Kowluru, Renu A

“…The retina experiences increased oxidative stress in diabetes, and the transcriptional activity of Nrf2, which is critical in regulating many antioxidant…”
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Epigenetic Modification of Mitochondrial DNA in the Development of Diabetic Retinopathy by Mishra, Manish, Kowluru, Renu A

“…Retinal mitochondria are dysfunctional in diabetes, and mitochondrial DNA (mtDNA) is damaged and its transcription is compromised. Our aim was to investigate…”
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Cross Talks between Oxidative Stress, Inflammation and Epigenetics in Diabetic Retinopathy by Kowluru, Renu A

“…Diabetic retinopathy, one of the most devastating complications of diabetes, is a multifactorial progressing disease with a very complex etiology. Although…”
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Transcription factor Nrf2-mediated antioxidant defense system in the development of diabetic retinopathy by Zhong, Qing, Mishra, Manish, Kowluru, Renu A

“…Increase in reactive oxygen species (ROS) is one of the major retinal metabolic abnormalities associated with the development of diabetic retinopathy…”
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Epigenetic Changes in Mitochondrial Superoxide Dismutase in the Retina and the Development of Diabetic Retinopathy by QING ZHONG, KOWLURU, Renu A

“…To investigate the role of epigenetic regulation of the manganese superoxide dismutase gene (sod2) in the development of diabetic retinopathy and the metabolic…”
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Epigenetics and Regulation of Oxidative Stress in Diabetic Retinopathy by Duraisamy, Arul J, Mishra, Manish, Kowluru, Anjaneyulu, Kowluru, Renu A

“…Oxidative stress plays a central role in the development of diabetic retinopathy, and in the pathogenesis of this blinding disease, activation of NADPH oxidase…”
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Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy by Kowluru, Renu A, Shan, Yang, Mishra, Manish

“…Diabetes elevates matrix metalloproteinase-9 (MMP-9) in the retina and its capillary cells, and activated MMP-9 damages mitochondria, accelerating retinal…”
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Homocysteine Disrupts Balance between MMP-9 and Its Tissue Inhibitor in Diabetic Retinopathy: The Role of DNA Methylation by Mohammad, Ghulam, Kowluru, Renu A

“…High homocysteine is routinely observed in diabetic patients, and this non-protein amino acid is considered as an independent risk factor for diabetic…”
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Mitochondrial Quality Control and Metabolic Memory Phenomenon Associated with Continued Progression of Diabetic Retinopathy by Kowluru, Renu A, Alka, Kumari

“…Diabetic retinopathy continues to progress even when hyperglycemia is terminated, suggesting a 'metabolic memory' phenomenon. Mitochondrial dysfunction is…”
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Regulation of Matrix Metalloproteinase in the Pathogenesis of Diabetic Retinopathy by Kowluru, Renu A, Mishra, Manish

“…Diabetic retinopathy, a progressive disease, is the major cause of acquired blindness in the developed countries. Despite cutting-edge research in the field,…”
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Role of histone acetylation in the development of diabetic retinopathy and the metabolic memory phenomenon by Zhong, Qing, Kowluru, Renu A.

“…Hyperglycemia is considered as one of the major determinants in the development of diabetic retinopathy, but the progression of retinopathy resists arrest…”
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Role of matrix metalloproteinase-9 in the development of diabetic retinopathy and its regulation by H-Ras by Kowluru, Renu A

“…Diabetes activates a small molecular weight G-protein, H-Ras, in the retina and its capillary cells, and H-Ras activation is implicated in the apoptosis of…”
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Sirt1, a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy by Kowluru, Renu A, Santos, Julia M, Zhong, Qing

“…In the pathogenesis of diabetic retinopathy, matrix metalloproteinase (MMP)-9 damages retinal mitochondria, activating the apoptotic machinery. Transcription…”
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Long Noncoding RNAs and Mitochondrial Homeostasis in the Development of Diabetic Retinopathy by Kowluru, Renu A

“…Retinopathy is one of the most devastating complications of diabetes, which a patient fears the most. Hyperglycemic environment results in many structural,…”
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Regulation of serine palmitoyl-transferase and Rac1–Nox2 signaling in diabetic retinopathy by Alka, Kumari, Mohammad, Ghulam, Kowluru, Renu A.

“…Hyperlipidemia is considered as one of the major systemic factors associated with the development of diabetic retinopathy, and animal models have documented…”
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Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes by Duraisamy, Arul J, Mishra, Manish, Kowluru, Renu A

“…Diabetes activates matrix metalloproteinase-9 (MMP-9), and MMP-9 via damaging retinal mitochondria, activates capillary cell apoptosis. MMP-9 promoter has…”
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Diabetic Retinopathy and NADPH Oxidase-2: A Sweet Slippery Road by Kowluru, Renu A.

“…Diabetic retinopathy remains the leading cause of vision loss in working-age adults. The multi-factorial nature of the disease, along with the complex…”
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Lipotoxicity augments glucotoxicity-induced mitochondrial damage in the development of diabetic retinopathy by Kumar, Binit, Kowluru, Anjan, Kowluru, Renu A

“…Although hyperglycemia is the main instigator in the development of diabetic retinopathy, dyslipidemia is also considered to play an important role. In the…”
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Molecular Mechanism of Transcriptional Regulation of Matrix Metalloproteinase-9 in Diabetic Retinopathy by Mishra, Manish, Flaga, Jadwiga, Kowluru, Renu A.

“…Increase in matrix metalloproteinase‐9 (MMP‐9) is implicated in retinal capillary cell apoptosis, a phenomenon which precedes the development of diabetic…”
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Regulation of Rac1 transcription by histone and DNA methylation in diabetic retinopathy by Kowluru, Renu A., Radhakrishnan, Rakesh, Mohammad, Ghulam

“…Cytosolic ROS, generated by NADPH oxidase 2 (Nox2) in diabetes, damage retinal mitochondria, which leads to the development of retinopathy. A small molecular…”
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