Search Results - "Kowar, Silke"

PI3K/AKT signaling allows for MAPK/ERK pathway independency mediating dedifferentiation-driven treatment resistance in melanoma by Corrales, Eyleen, Levit-Zerdoun, Ella, Metzger, Patrick, Mertes, Ralf, Lehmann, Ariane, Münch, Julia, Lemke, Steffen, Kowar, Silke, Boerries, Melanie

“…Current therapeutic management of advanced melanoma patients largely depends on their BRAF mutation status. However, the vast heterogeneity of the tumors…”
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Identification and Validation of a Diagnostic and Prognostic Multi-Gene Biomarker Panel for Pancreatic Ductal Adenocarcinoma by Klett, Hagen, Fuellgraf, Hannah, Levit-Zerdoun, Ella, Hussung, Saskia, Kowar, Silke, Küsters, Simon, Bronsert, Peter, Werner, Martin, Wittel, Uwe, Fritsch, Ralph, Busch, Hauke, Boerries, Melanie

“…Late diagnosis and systemic dissemination essentially contribute to the invariably poor prognosis of pancreatic ductal adenocarcinoma (PDAC). Therefore, the…”
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Dynamic transcriptome analysis reveals signatures of paradoxical effect of vemurafenib on human dermal fibroblasts by Corrales, Eyleen, Levit-Zerdoun, Ella, Metzger, Patrick, Kowar, Silke, Ku, Manching, Brummer, Tilman, Boerries, Melanie

“…Vemurafenib (PLX4032) is one of the most frequently used treatments for late-stage melanoma patients with the BRAF mutation; however, acquired resistance to…”
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Boolean approach to signalling pathway modelling in HGF-induced keratinocyte migration by Singh, Amit, Nascimento, Juliana M, Kowar, Silke, Busch, Hauke, Boerries, Melanie

“…Cell migration is a complex process that is controlled through the time-sequential feedback regulation of protein signalling and gene regulation. Based on…”
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B-Raf inhibitors induce epithelial differentiation in BRAF-mutant colorectal cancer cells by Herr, Ricarda, Köhler, Martin, Andrlová, Hana, Weinberg, Florian, Möller, Yvonne, Halbach, Sebastian, Lutz, Lisa, Mastroianni, Justin, Klose, Martin, Bittermann, Nicola, Kowar, Silke, Zeiser, Robert, Olayioye, Monilola A, Lassmann, Silke, Busch, Hauke, Boerries, Melanie, Brummer, Tilman

“…BRAF mutations are associated with aggressive, less-differentiated and therapy-resistant colorectal carcinoma. However, the underlying mechanisms for these…”
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Boolean Modeling Reveals the Necessity of Transcriptional Regulation for Bistability in PC12 Cell Differentiation by Offermann, Barbara, Knauer, Steffen, Singh, Amit, Fernández-Cachón, María L, Klose, Martin, Kowar, Silke, Busch, Hauke, Boerries, Melanie

“…The nerve growth factor NGF has been shown to cause cell fate decisions toward either differentiation or proliferation depending on the relative activity of…”
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