Beneficial Effect of Successful Simultaneous Pancreas-Kidney Transplantation on Plasma Profile of Metalloproteinases in Type 1 Diabetes Mellitus Patients

Beneficial Effect of Successful Simultaneous Pancreas-Kidney Transplantation on Plasma Profile of Metalloproteinases in Type 1 Diabetes Mellitus Patients

It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave veloci...

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Published in:Journal of clinical medicine Vol. 10; no. 17; p. 3800
Main Authors: Chudek, Jerzy, Kolonko, Aureliusz, Ziaja, Jacek, Francuz, Tomasz, Kamińska, Dorota, Owczarek, Aleksander J., Kuczera, Piotr, Kujawa-Szewieczek, Agata, Kusztal, Mariusz, Kowalik, Adrian P., Bożek-Pająk, Dominika, Kluz, Joanna, Choręza, Piotr, Król, Robert, Krajewska, Magdalena, Cierpka, Lech, Więcek, Andrzej
Format: Journal Article
Language:English
Published: Basel MDPI AG 25-08-2021
MDPI
Subjects:
Atherosclerosis
Blood pressure
Calcification
Carotid arteries
Clinical medicine
Diabetes
Kidney transplants
Laboratories
Normal distribution
Patients
Plasma
Statistical analysis
Veins & arteries
United States > US
Czech Republic
Germany
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Summary:It is not fully elucidated whether the restoring of normal glucose metabolism after successful simultaneous pancreas-kidney transplantation (SPK) improves vascular wall morphology and function in type 1 diabetic (T1D) patients. Therefore, we compared arterial stiffness, assessed by pulse wave velocity (PWV), carotid intima-media thickness (IMT), and biomarkers of arterial wall calcification in T1D patients after SPK or kidney transplantation alone (KTA). In 39 SPK and 39 KTA adult patients of similar age, PWV, IMT, circulating matrix metalloproteinases (MMPs) and calcification biomarkers were assessed at median 83 months post transplantation. Additionally, carotid plaques were visualized and semi-qualitatively classified. Although PWV and IMT values were similar, the occurrence of atherosclerotic plaques (51.3 vs. 70.3%, p < 0.01) and calcified lesions (35.9 vs. 64.9%, p < 0.05) was lower in SPK patients. There were significantly lower concentrations of MMP-1, MMP-2, MMP-3, and osteocalcin in SPK subjects. Among the analyzed biomarkers, only logMMP-1, logMMP-2, and logMMP-3 concentrations were associated with log HbA1c. Multivariate stepwise backward regression analysis revealed that MMP-1 and MMP-3 variability were explained only by log HbA1c. Normal glucose metabolism achieved by SPK is followed by the favorable profile of circulating matrix metalloproteinases, which may reflect the vasoprotective effect of pancreas transplantation.
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ISSN:2077-0383
2077-0383
DOI:10.3390/jcm10173800