Search Results - "Kowalczyk, Bruce A"

Synthesis of the Spatane Nucleus (cis-anti-cis-tricyclo[5.3.0.02,6]decane) using the Pauson−Khand Reaction with a Remarkable Reversal in Regioselectivity by Kowalczyk, Bruce A, Smith, Timothy C, Dauben, William G

“…The Pauson−Khand reaction of cyclobutenes 3−5 with a variety of acetylenes yielded cis-anti cis-tricyclo[5.3.0.02,6]decanes 9−17. The unwanted regioisomers 9a…”
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2-(Quinuclidin-3-yl)pyrido[4,3-b]indol-1-ones and isoquinolin-1-ones. Potent conformationally restricted 5-HT3 receptor antagonists by Clark, Robin D, Miller, Aaron B, Berger, Jacob, Repke, David B, Weinhardt, Klaus K, Kowalczyk, Bruce A, Eglen, Richard M, Bonhaus, Douglas W, Lee, Chi Ho

“…Several series of N-(quinuclidin-3-yl)aryl and heteroaryl-fused pyridones were synthesized and evaluated for 5-HT3 receptor affinity. In the heteroaryl series,…”
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Process Development of the Synthetic Route to Sulamserod Hydrochloride by Kowalczyk, Bruce A, Robinson, Gardner, John O

“…Sulamserod hydrochloride is a potent 5-HT4 receptor antagonist and was a clinical candidate for the treatment of gastrointestinal disorders. Process…”
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A Short Total Synthesis of Palonosetron Using Catalytic Hydrogenation by A. Kowalczyk, Bruce

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Scale-Up of the Nitration of 1-Acetyl-3,4-dichloro-1,2-(ethylenedioxy)benzene Using Nitric Acid/Trifluoroacetic Acid by Kowalczyk, Bruce A, Roberts, Philip N, McEwen, Gerald K, Robinson, James

“…The process development of the nitration of 3-acetyl-4,5-dichloro-1,2-(ethylenedioxy)benzene (1) to 3-acetyl-4,5-dichloro-1,2-(ethylenedioxy)-6-nitrobenzene…”
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Enantiomerically pure building blocks from sugars. 11. Diels-Alder reactions of pyranoid enolone esters with cyclopentadiene under thermal, Lewis acid catalysis, and high-pressure conditions by Dauben, William G, Kowalczyk, Bruce A, Lichtenthaler, Frieder W

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Sonication-induced halogenative decarboxylation of thiohydroxamic esters by Dauben, William G, Bridon, Dominique P, Kowalczyk, Bruce A

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Sonication-induced reductive decarboxylation of thiohydroxamic esters by Dauben, William G, Bridon, Dominique P, Kowalczyk, Bruce A

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Hydrogenation of a Chiral 1 H -Benz[ de ]isoquinolin-1-one and an Equilibration Using Palladium Catalyst by Kowalczyk, Bruce A., Dyson, Norman H.

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Hydrogenation of a Chiral 1H-Benz[de]isoquinolin-1-one and an Equilibration Using Palladium Catalyst by Kowalczyk, Bruce A, Dyson, Norman H

“…The catalytic hydrogenation of a chiral 1H-benz[de]isoquinolin-1-one to palonosetron and the undesired diastereomer was optimized using a variety of conditions…”
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