Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

Surface Modification of Mesoporous Silica Nanoparticles for Application in Targeted Delivery Systems of Antitumour Drugs

The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems...

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Bibliographic Details
Published in:Polymers Vol. 16; no. 8; p. 1105
Main Authors: Kovtareva, Svetlana, Kusepova, Lyazat, Tazhkenova, Gaukhar, Mashan, Togzhan, Bazarbaeva, Karlygash, Kopishev, Eldar
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 16-04-2024
MDPI
Subjects:
Biocompatibility
Cancer therapies
Chemotherapy
Drug delivery systems
Drug dosages
FDA approval
Functional groups
Immunotherapy
Kinases
Mortality
Nanoparticles
Polymers
Quantum dots
Radiation
Review
Side effects
Silica
Silicon dioxide
Surface properties
Surgery
System effectiveness
Toxicity
Transportation systems
Tumors
mesoporous silica
inorganic nanoparticles
drug delivery
polymers
anticancer drugs
surface modification
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Summary:The problem of tumour therapy has attracted the attention of many researchers for many decades. One of the promising strategies for the development of new dosage forms to improve oncology treatment efficacy and minimise side effects is the development of nanoparticle-based targeted transport systems for anticancer drugs. Among inorganic nanoparticles, mesoporous silica deserves special attention due to its outstanding surface properties and drug-loading capability. This review analyses the various factors affecting the cytotoxicity, cellular uptake, and biocompatibility of mesoporous silica nanoparticles (MSNs), constituting a key aspect in the development of safe and effective drug delivery systems. Special attention is paid to technological approaches to chemically modifying MSNs to alter their surface properties. The stimuli that regulate drug release from nanoparticles are also discussed, contributing to the effective control of the delivery process in the body. The findings emphasise the importance of modifying MSNs with different surface functional groups, bio-recognisable molecules, and polymers for their potential use in anticancer drug delivery systems.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
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ObjectType-Review-1
ISSN:2073-4360
2073-4360
DOI:10.3390/polym16081105