Search Results - "Kovnar, E H"

Medulloblastoma in very young children: outcome of definitive craniospinal irradiation following incomplete response to chemotherapy by Gajjar, A, Mulhern, R K, Heideman, R L, Sanford, R A, Douglass, E C, Kovnar, E H, Langston, J A, Jenkins, J J, Kun, L E

“…To evaluate survival and neurodevelopmental outcomes following radiation therapy in infants and young children with residual or progressive medulloblastoma…”
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High-dose chemotherapy and autologous bone marrow rescue followed by interstitial and external-beam radiotherapy in newly diagnosed pediatric malignant gliomas by Heideman, R L, Douglass, E C, Krance, R A, Fontanesi, J, Langston, J A, Sanford, R A, Kovnar, E H, Ochs, J, Kuttesch, J, Jenkins, J J

“…Evaluation of high-dose chemotherapy with autologous bone marrow rescue (ABMR) in pediatric malignant gliomas. Newly diagnosed (n = 11) and recurrent (n = 2)…”
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Preirradiation chemotherapy with carboplatin and etoposide in newly diagnosed embryonal pediatric CNS tumors by Heideman, R L, Kovnar, E H, Kellie, S J, Douglass, E C, Gajjar, A J, Walter, A W, Langston, J A, Jenkins, J J, Li, Y, Greenwald, C

“…We evaluated the clinical efficacy of preirradiation carboplatin (CARBO) and etoposide (VP-16) in 25 patients with newly diagnosed embryonal CNS tumors…”
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Preirradiation cisplatin and etoposide in the treatment of high-risk medulloblastoma and other malignant embryonal tumors of the central nervous system: a phase II study by Kovnar, E H, Kellie, S J, Horowitz, M E, Sanford, R A, Langston, J W, Mulhern, R K, Jenkins, J J, Douglass, E C, Etcubanas, E E, Fairclough, D L

“…Medulloblastoma, pineoblastoma, and cerebral neuroblastoma are malignant embryonal tumors of the CNS that may demonstrate similar histologic features, a…”
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Current therapy and new perspectives in the treatment of medulloblastoma by Whelan, Harry T., Krouwer, Hendrikus G., Schmidt, Meic H., Reichert, Kenneth W., Kovnar, Edward H.

“…Medulloblastoma, a malignant tumor arising from the medullary velum, is the most common malignant brain tumor of childhood. Local extension into the cerebellar…”
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Neurodevelopmental status of infants and young children treated for brain tumors with preirradiation chemotherapy by Mulhern, R K, Horowitz, M E, Kovnar, E H, Langston, J, Sanford, R A, Kun, L E

“…In an effort to reduce the severity of late neurotoxicities associated with cranial irradiation, 14 infants and young children with malignant brain tumors were…”
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Multiple causes of cerebrovascular events in children with tumors of the parasellar region by RUDOLTZ, M. S, REGINE, W. F, LANGSTON, J. W, SANFORD, R. A, KOVNAR, E. H, KUN, L. E

“…Cerebrovascular arterial occlusion is a rare but devastating event causing long-term morbidity in children with tumors in the parasellar region. While usually…”
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A phase II evaluation of thiotepa in pediatric central nervous system malignancies by Heideman, R L, Packer, R J, Reaman, G H, Allen, J C, Lange, B, Horowitz, M E, Steinberg, S M, Gillespie, A, Kovnar, E H, Balis, F M

“…Both thiotepa and its active metabolite, tepa, efficiently cross the blood-brain barrier. After intravenous administration, the cerebrospinal fluid…”
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Relation of tumor-cell ploidy to survival in children with medulloblastoma by Gajjar, A J, Heideman, R L, Douglass, E C, Kun, L E, Kovnar, E H, Sanford, R A, Fairclough, D L, Ayers, D, Look, A T

“…To assess the value of tumor-cell ploidy as a predictor of survival in medulloblastoma. Ploidy determinations were based on the flow-cytometric analysis of…”
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Predominance of pilocytic histology in dorsally exophytic brain stem tumors by Khatib, Z A, Heideman, R L, Kovnar, E H, Langston, J A, Sanford, R A, Douglas, E C, Ochs, J, Jenkins, J J, Fairclough, D L, Greenwald, C

“…We report the magnetic resonance imaging (MRI) and clinico-histologic characterization of dorsally exophytic brain stem gliomas (DEBSGs). Between 1983 and…”
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Potentiation of ifosfamide neurotoxicity, hematotoxicity, and tubular nephrotoxicity by prior cis-diamminedichloroplatinum(II) therapy by GOREN, M. P, WRIGHT, R. K, PRATT, C. B, HOROWITZ, M. E, DODGE, R. K, VIAR, M. J, KOVNAR, E. H

“…We investigated the relationship between prior therapy and three distinct forms of toxicity that developed during ifosfamide administration (1.6 g/m2/day for 5…”
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A phase II study of every other day high-dose ifosfamide in pediatric brain tumors : a pediatric oncology group study by HEIDEMAN, R. L, DOUGLASS, E. C, LANGSTON, J. A, KRISCHER, J. P, BURGER, P. C, KOVNAR, E. H, KUN, L. E, FRIEDMAN, H. S, KADOTA, R

“…Despite reported activity in many other solid tumors, high-dose ifosfamide produces few objective responses in recurrent pediatric brain tumors. Alkylating…”
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A phase I study of ifosfamide given on alternate days to treat children with brain tumors by Pratt, C B, Douglass, E C, Kovnar, E H, Heideman, R, Kun, L, Avery, L, Kellie, S J

“…Ifosfamide with Mesna, given every other day over a 5-day period, was evaluated in 20 children with recurrent or progressive primary brain tumors. The patients…”
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Hyperfractionated irradiation and concurrent cisplatin in brain stem tumors: a Pediatric Oncology Group pilot study (9139) by Kadota, R P, Mandell, L R, Fontanesi, J, Kovnar, E H, Krischer, J, Kun, L E, Friedman, H S

“…A phase I Pediatric Oncology Group Study was performed combining 7,020 cGy hyperfractionated irradiation (117 cGy twice daily separated by 6 h) with increasing…”
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Ependymomas in children by Kun, L E, Kovnar, E H, Sanford, R A

“…Ependymomas originate throughout the central nervous system (CNS), representing 10-12% of CNS tumors in children. The majority occur in children less than 5…”
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Response of pediatric low grade gliomas to chemotherapy by Gajjar, A, Heideman, R L, Kovnar, E H, Langston, J A, Sanford, R A, Douglass, E C, Jenkins, J J, Horowitz, M E, Kun, L E

“…Thirteen patients with low grade astrocytomas were treated with alkylating agent or platinum-based chemotherapy regimens. Eleven of these patients received…”
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Neuraxis dissemination in pediatric brain tumors. Response to preirradiation chemotherapy by Kellie, S J, Kovnar, E H, Kun, L E, Horowitz, M E, Heideman, R L, Douglass, E C, Langston, J W, Sanford, R A, Jenkins, 3rd, J J, Fairclough, D L

“…Of 29 consecutive children treated for malignant primary tumors of the central nervous system (CNS) at this institution, postoperative examination showed…”
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Quality of survival among children treated for brain stem glioma by Mulhern, R K, Heideman, R L, Khatib, Z A, Kovnar, E H, Sanford, R A, Kun, L E

“…In order to describe the status of long-term survivors of brain stem glioma, neuropsychological and behavioral measures were obtained a median of 2.5 (range…”
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Arachnoid cyst of the quadrigeminal plate cistern: report of two cases by CHOI, S. K, STARSHAK, R. J, MEYER, G. A, KOVNAR, E. H, STY, J. R

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Psychologic and neurologic function following treatment for childhood temporal lobe astrocytoma by Mulhern, R K, Kovnar, E H, Kun, L E, Crisco, J J, Williams, J M

“…Seven school-aged children treated for temporal lobe astrocytomas with surgical resection and irradiation were prospectively tested to evaluate their…”
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