Search Results - "Kovatch, R.M"

Reduction of the Infectivity of Scrapie Agent as a Model for BSE in the Manufacturing Process of Trasylol by Gölker, C.F., Whiteman, M.D., Gugel, K.H., Gilles, R., Stadler, P., Kovatch, R.M., Lister, D., Wisher, M.H., Calcagni, C., Hübner, G.E.

“…The Trasylol ®manufacturing process was investigated with respect to its capacity for the inactivation/removal of infectivity causing bovine spongiform…”
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Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice by Beland, F.A, Benson, R.W, Mellick, P.W, Kovatch, R.M, Roberts, D.W, Fang, J.L, Doerge, D.R

“…Urethane is a carcinogen to which there is widespread exposure through the consumption of fermented foods and alcoholic beverages. In this study, we have…”
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Carcinogenesis in rats by cyclic N-nitrosamines containing sulphur by Lijinsky, W, Kovatch, R M, Keefer, L K, Saavedra, J E, Hansen, T J, Miller, A J, Fiddler, W

“…The effects of chronic exposure to three sulphur-containing heterocyclic N-nitrosamines were determined after repeated oral administration to female Fischer…”
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Carcinogenesis by nitrosomorpholines, nitrosooxazolidines and nitrosoazetidine given by gavage to Syrian golden hamsters by Lijinsky, W, Kovatch, R M, Knutsen, G L

“…Five cyclic nitrosamines, four containing oxygen in the ring, were administered by gavage to groups of 20 male Syrian golden hamsters. After administration of…”
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The carcinogenic effect of methapyrilene combined with nitrosodiethylamine given to rats in low doses by Lijinsky, W, Kovatch, R M, Thomas, B J

“…The carcinogenic effects of combinations of methapyrilene hydrochloride (MP), nitrosodiethylamine (NDEA), and phenobarbital (PB) or partial hepatectomy (PH)…”
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Tumorigenicity of the tobacco-specific carcinogen 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone in infant mice by Anderson, L M, Hecht, S S, Kovatch, R M, Amin, S, Hoffmann, D, Rice, J M

“…The tobacco-specific nitrosamine, 4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK), is a potent carcinogen in adult rodents and variably effective…”
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Chronic toxicity tests of sodium thiocyanate with sodium nitrite in F344 rats by Lijinsky, W, Kovatch, R M

“…Sodium thiocyanate, a common environmental chemical, was found to increase the incidence of liver tumors in a group of rats treated with 0.08% in drinking…”
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Gross and Microscopic Lesions in the Female SENCAR Mouse Skin and Lung in Tumor Initiation and Promotion Studies by Knutsen, Gary L., Kovatch, Robert M., Robinson, Merrel

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Effect of pretreatment with beta-naphthoflavone on tumorigenesis by N-nitrosoethylurea in five mouse strains by Anderson, L M, Jones, A B, Kovatch, R M

“…The non-carcinogenic inducer of the Ah locus, beta-naphthoflavone (beta NF), was administered to females of 5 mouse strains at a dose of 150 mg/kg 48 h before…”
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Similar carcinogenic effects in rats of 1-ethyl-1-nitroso-3-hydroxyethylurea and 1-hydroxyethyl-1-nitroso-3-ethylurea by Lijinsky, W, Singer, G M, Kovatch, R M

“…The two isomeric N-nitroso derivatives of the dialkylurea, 1-ethyl-3-(2-hydroxyethyl)urea, were given by gavage to 20 male F344 rats for 30 weeks at equimolar…”
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Carcinogenesis by nitrosobis-(2-oxopropyl)amine labeled with deuterium and by nitroso-2-hydroxypropyl-2-oxopropylamine in rats and hamsters by Lijinsky, W, Saavedra, J E, Kovatch, R M

“…The effects of the labeling with deuterium of the alpha-methylene groups of the carcinogen nitrosobis-(2-oxopropyl)amine (NBOP) on its carcinogenic…”
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Carcinogenesis and nucleic acid alkylation by some oxygenated nitrosamines in rats and hamsters by Lijinsky, W, Saavedra, J E, Kovatch, R M

“…A comparison has been made of the carcinogenic effects of nitroso-2,6-dimethylmorpholine and several hydroxylated acyclic nitrosodialkylamines derived from it…”
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Carcinogenesis by nitroso-2-hydroxyethylurea in splenectomized hamsters by Lijinsky, W, Kovatch, R M, Thomas, B J

“…Several nitrosoalkylureas tested for carcinogenic activity in Syrian hamsters have as their main effect the induction of hemangiosarcomas of the spleen, many…”
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Lack of effect of selenium on induction of tumors of esophagus and bladder in rats by two nitrosamines by Lijinsky, W, Milner, J A, Kovatch, R M, Thomas, B J

“…The effect of differences in level of dietary selenium on the induction of esophageal and bladder tumors in rats by two nitrosamines was investigated. Groups…”
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N-nitrosocimetidine as a modifier of chemically-initiated tumors in mice by Anderson, L M, Hagiwara, A, Giner-Sorolla, A, Kovatch, R M, Rehm, S, Riggs, C W, Rice, J M

“…N-Nitrosocimetidine (NCM) is a nitrosation product of cimetidine, a commonly-prescribed pharmaceutical agent. In spite of its known genotoxicity, NCM has…”
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Tumors in F344 rats by oral administration of 1,3-diethyltriazene by Smith, Jr, R H, Kovatch, R M, Lijinsky, W, Thomas, B J, Michejda, C J

“…A group of 20 male F344 rats was given by gavage a solution of 2.5 mg of 1,3-diethyltriazene in 0.2 ml corn oil twice a week for 20 weeks. Diethyltriazene is…”
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Intraperitoneal mesotheliomas induced in mice by a polycyclic aromatic hydrocarbon by Rice, J M, Kovatch, R M, Anderson, L M

“…Female mice of 6 strains (C3H/HeN, BALB/c, C57BL/6N, DBA/2, NIH Swiss, and AKR/N) were given the polycyclic aromatic hydrocarbon carcinogen…”
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Trypanosoma congolense: natural and acquired resistance in the bovine by Wellde, B T, Hockmeyer, W T, Kovatch, R M, Bhogal, M S, Diggs, C L

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Haemorrhagic syndrome in cattle associated with Trypanosoma vivax infection by Wellde, B.T, Chumo, D.A, Adoyo, M, Kovatch, R.M, Mwongela, G.N

“…Trypanosoma vivax, Ayrshire steers, experimental study on pathogenesis of haemorrhagic syndrome using isolate derived from dairy cattle during outbreak of…”
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Trypanosoma congolense: calf erythrocyte survival by Preston, J M, Wellde, B T, Kovatch, R M

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