Search Results - "Kovarik, M."

Mu-opioid receptor inhibition decreases voluntary wheel running in a dopamine-dependent manner in rats bred for high voluntary running by Ruegsegger, Gregory N, Brown, Jacob D, Cathleen Kovarik, M, Miller, Dennis K, Booth, Frank W

“…Highlights • Intrinsic Oprm1 function was increased in the NAc of HVR compared to LVR rats. • Intraperitoneal naltrexone reduced dopamine-related mRNAs,…”
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Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral Mammalian Target of Rapamycin Inhibitor Everolimus in Patients With Advanced Solid Tumors by O'DONNELL, Anne, FAIVRE, Sandrine, BROCK, Cathryn, JONES, Suzanne, RAYMOND, Eric, JUDSON, Ian, BURRIS, Howard A, REA, Daniel, PAPADIMITRAKOPOULOU, Vassiliki, SHAND, Nicholas, LANE, Heidi A, HAZELL, Katharine, ZOELLNER, Ulrike, KOVARIK, John M

“…To identify the optimal regimen and dosage of the oral mammalian target of rapamycin inhibitor everolimus (RAD001). We performed a dose-escalation study in…”
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Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data by TANAKA, Chiaki, O'REILLY, Terence, HATTENBERGER, Marc, THOMAS, George, LANE, Heidi A, KOVARIK, John M, SHAND, Nicholas, HAZELL, Katharine, JUDSON, Ian, RAYMOND, Eric, ZUMSTEIN-MECKER, Sabine, STEPHAN, Christine, BOULAY, Anne

“…To use preclinical and clinical pharmacokinetic (PK)/pharmacodynamic (PD) modeling to predict optimal clinical regimens of everolimus, a novel oral mammalian…”
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Effect of beta-hydroxy-beta-methylbutyrate (HMB) on protein metabolism in whole body and in selected tissues by Holecek, M., Muthny, T., Kovarik, M., Sispera, L.

“…Beta-hydroxy-beta-methylbutyrate (HMB) is a leucine metabolite with protein anabolic effect. The aim of the study was to examine the role of exogenous HMB on…”
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Critical evaluation of muscle mass loss as a prognostic marker of morbidity in critically ill patients and methods for its determination by Joskova, Vera, Patkova, Anna, Havel, Eduard, Najpaverova, Simona, Uramova, Daniela, Kovarik, Miroslav, Zadak, Zdenek, Hronek, Miloslav

“…Loss of muscle mass in critically ill patients is associated with serious consequences, such as prolonged mechanical ventilation, intensive care unit…”
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Estradiol directly attenuates sodium currents and depolarizing afterpotentials in isolated gonadotropin-releasing hormone neurons by Wang, Yong, Kuehl-Kovarik, M. Cathleen

“…Abstract The gonadotropin-releasing hormone (GnRH) neuron is the pivotal control center in a tightly regulated reproductive axis. The release of GnRH controls…”
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The bioimpedance spectroscopy as useful tool for measuring the fluid excess and fluid management in severe polytrauma patients by Joskova, V., Patkova, A., Havel, E., Najpaverova, S., Uramova, D., Kovarik, M., Zadak, Z., Hronek, M.

“…Although the fluid therapy plays a fundamental role in the management of polytrauma patients (PP), a tool which could determine it appropriately is still…”
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SUN-P014: The Effect of Energy and Nutritional Substrate Intake on their Oxidation and the Energy Expenditure in Polytrauma Patients in ICU by Patkova, A, Joskova, V, Havel, E, Kovarik, M, Zadak, Z, Hronek, M

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Episodic Bursting Activity and Response to Excitatory Amino Acids in Acutely Dissociated Gonadotropin-Releasing Hormone Neurons Genetically Targeted with Green Fluorescent Protein by Kuehl-Kovarik, M. Cathleen, Pouliot, Wendy A, Halterman, Gloriana L, Handa, Robert J, Dudek, F. Edward, Partin, Kathryn M

“…The gonadotropin-releasing hormone (GnRH) system, considered to be the final common pathway for the control of reproduction, has been difficult to study…”
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Multiple-Dose FTY720: Tolerability, Pharmacokinetics, and Lymphocyte Responses in Healthy Subjects by Kovarik, John M., Schmouder, Robert, Barilla, Denise, Riviere, Gilles-Jacques, Wang, Yibin, Hunt, Thomas

“…FTY720 is a sphingosine‐1‐phosphate receptor agonist being developed as an immunomodulator for acute rejection prophylaxis after organ transplantation. This…”
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PP145-MON: Skinfold Anthropometry – the Accurate Method for Determination of Fat and Fat Free Mass in COPD by Hronek, M, Kovarik, M, Pavlickova, P.A, Koblizek, V, Zadak, Z

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SUN-PP063: The Resting Energy Expenditure and Utilization of Nutritive Substrates and in Polytrauma Patients in the ICU by Hronek, M, Kovarik, M, Havel, E, Patková, A, Joskova, V, Rybakova, K, Zadak, Z

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Hand grip endurance test relates to clinical state and prognosis in COPD patients better than 6-minute walk test distance by Kovarik, Miroslav, Joskova, Vera, Patkova, Anna, Koblizek, Vladimir, Zadak, Zdenek, Hronek, Miloslav

“…Patients with COPD present peripheral muscle dysfunction and atrophy, expressed as muscle strength and endurance reduction. The goal of this study was direct…”
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Estradiol attenuates multiple tetrodotoxin-sensitive sodium currents in isolated gonadotropin-releasing hormone neurons by Wang, Yong, Garro, Mona, Kuehl-Kovarik, M. Cathleen

“…Abstract Secretion from gonadotropin-releasing hormone (GnRH) neurons is necessary for the production of gametes and hormones from the gonads. Subsequently,…”
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Exposure-response relationships for everolimus in de novo kidney transplantation: Defining a therapeutic range by KOVARIK, John M, KAPLAN, Bruce, SILVA, Hélio Tedesco, KAHAN, Barry D, DANTAL, Jacque, VITKO, Stefan, BOGER, Robert, RORDORF, Christiane

“…Exposure, safety, and efficacy data from the two everolimus randomized, double-blind phase 3 trials were evaluated to identify a therapeutic concentration…”
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Single‐dose FTY720 pharmacokinetics, food effect, and pharmacological responses in healthy subjects by Kovarik, John M., Schmouder, Robert, Barilla, Denise, Wang, Yibin, Kraus, Gerolf

“…Aims FTY720 is a sphingosine‐1‐phosphate receptor agonist that redirects lymphocytes from the circulation to lymph nodes without impairing lymphocyte function…”
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Pharmacokinetic interaction between verapamil and everolimus in healthy subjects by Kovarik, J. M., Beyer, D., Bizot, M. N., Jiang, Q., Allison, M. J., Schmouder, R. L.

“…Aims We sought to define the influence of verapamil, an inhibitor of CYP3A and P‐glycoprotein, on the pharmacokinetics of everolimus, a substrate of this…”
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Blood Concentrations of Everolimus Are Markedly Increased by Ketoconazole by Kovarik, J. M., Beyer, D., Bizot, M. N., Jiang, Q., Shenouda, M., Schmouder, R. L.

“…The authors sought to quantify the influence of the CYP3A and P‐glycoprotein inhibitor ketoconazole on the pharmacokinetics of everolimus in healthy subjects…”
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Flufenamic acid modulates multiple currents in gonadotropin-releasing hormone neurons by Wang, Yong, Kuehl-Kovarik, M. Cathleen

“…Abstract Reproduction in mammals is dependent upon the appropriate neurosecretion of gonadotropin-releasing hormone (GnRH), yet the endogenous generation of…”
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Therapeutic Drug Monitoring for Everolimus in Heart Transplant Recipients Based on Exposure–Effect Modeling by Starling, Randall C., Hare, Joshua M., Hauptman, Paul, McCurry, Kenneth R., Mayer, Hartmut W., Kovarik, John M., Schmidli, Heinz

“…Everolimus, a proliferation signal inhibitor, is an immunosuppressant that targets the primary causes of progressive allograft dysfunction, thus improving the…”
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