Search Results - "Kovalska, V. B."

Specific fluorescent detection of fibrillar α-synuclein using mono- and trimethine cyanine dyes by Volkova, K.D., Kovalska, V.B., Balanda, A.O., Losytskyy, M.Yu, Golub, A.G., Vermeij, R.J., Subramaniam, V., Tolmachev, O.I., Yarmoluk, S.M.

“…Firstly, fluorescent cyanine dyes (monomethine T-284 and trimethine SH-516) are proposed for selective fluorescent detection of fibrillar α-synuclein. Studies…”
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Fluorescent homodimer styrylcyanines: synthesis and spectral-luminescent studies in nucleic acids and protein complexes by Kovalska, V.B., Kryvorotenko, D.V., Balanda, A.O., Losytskyy, M.Yu, Tokar, V.P., Yarmoluk, S.M.

“…A series of homodimer styrylcyanine dyes based on ( p-dimethylaminostyryl)pyridinium, ( p-dimethylaminostyryl)benzoxazolium, (…”
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Fluorescent Detection of a Partially Unfolded Conformation of Beta-Lactoglobulin Using Squaraine Dyes by Kovalska, V.B., Losytskyy, M.Yu, Reis, L.V., Santos, P.F., Yarmoluk, S.M.

“…Summary Six benzothiazole squaraine dyes were studied as fluorescent probes for detection of thermally‐induced conformation changes of amyloidogenic protein…”
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Novel fluorescent trimethine cyanine dye 7519 for amyloid fibril inhibition assay by Volkova, K D, Kovalska, V B, Inshin, D, Slominskii, Y L, Tolmachev, O I, Yarmoluk, S M

“…Fluorescence spectroscopy was used to study the ability of dye 7519 to follow the transition of monomeric insulin into fibrils and applicability of the dye to…”
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Development of a quantitative structure activity relations (QSAR) model to guide the design of fluorescent dyes for detecting amyloid fibrils by Inshyn, D I, Kovalska, V B, Losytskyy, M Y, Slominskii, Yl, Tolmachev, O I, Yarmoluk, S M

“…Quantitative structure activity relationship (QSAR) studies were performed on a set of polymethine compounds to develop new fluorescent probes for detecting…”
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Symmetric cyanine dyes for detecting nucleic acids by Yarmoluk, Sm, Kovalska, Vb, Losytskyy, My

“…A novel approach to the design of sensitive fluorescent probes for nucleic acids detection is proposed. Suitable modifications of tri- and pentamethine cyanine…”
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Synthesis of novel fluorescent styryl dyes based on the imidazo[1,2- a]pyridinium chromophore and their spectral-fluorescent properties in the presence of nucleic acids and proteins by Kovalska, V.B., Losytskyy, M.Yu, Kryvorotenko, D.V., Balanda, A.O., Tokar, V.P., Yarmoluk, S.M.

“…The imidazo[1,2- a]pyridinium heterocyclic system was used to prepare styryl dyes. Improved synthetic methods were proposed for the parent imidazo[1,2-…”
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Explorations of the application of cyanine dyes for quantitative alpha-synuclein detection by Volkova, K D, Kovalska, V B, Segers-Nolten, G M, Veldhuis, G, Subramaniam, V, Yarmoluk, S M

“…We examined the practical aspects of using fluorescent mono (T-284) and trimethinecyanine (SH-516) dyes for detecting and quantifying fibrillar alpha-synuclein…”
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Interactions of cyanine dyes with nucleic acids. XXIV. Aggregation of monomethine cyanine dyes in presence of DNA and its manifestation in absorption and fluorescence spectra by Ogul'chansky, T.Yu, Losytskyy, M.Yu, Kovalska, V.B, Yashchuk, V.M, Yarmoluk, S.M

“…Absorption, fluorescence emission and excitation spectra of benzothiazole cyanine dyes — thiazole orange (TO) and…”
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Tri- and Pentamethine Cyanine Dyes for Fluorescent Detection of α-Synuclein Oligomeric Aggregates by Kovalska, V. B., Losytskyy, M. Yu, Tolmachev, O. I., Slominskii, Yu L., Segers-Nolten, G. M. J., Subramaniam, V., Yarmoluk, S. M.

“…The pathogenesis of Parkinson’s disease that is the second most common neurodegenerative disease is associated with formation of different aggregates of…”
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Variation of photostability of DNA-sensitive styrylcyanine dyes caused by N-alkyl functionalization by Snihirova, Y. V., Losytskyy, M. Yu, Kryvorotenko, D. V., Kuperman, M. V., Moshynets, O. V., Yarmoluk, S. M., Mokhir, A., Kovalska, V. B.

“…Aim. Synthesis and characterization of benzothiazole-based styrylcyanines functionalized by different N-alkyl tail groups as potential photostable probes for…”
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Fluorescent properties of pentamethine cyanine dyes with cyclopentene and cyclohexene group in presence of biological molecules by Losytskyy, M Yu, Volkova, K D, Kovalska, V B, Makovenko, I E, Slominskii, Yu L, Tolmachev, O I, Yarmoluk, S M

“…A series of pentamethine cyanine dyes with cyclohexene or cyclopentene group in polymethyne chain, assumed as DNA groove-binders, were studied as fluorescent…”
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Luminescence spectroscopic studies of trimethinecyanines substituted in polymethine chain with nucleic acids and proteins by Kovalska, V.B., Losytskyy, M.Yu, Yarmoluk, S.M.

“…The series of symmetrical β-substituted and α,γ-substituted trimethinecyanine dyes were studied for their absorption and fluorescent characteristics in unbound…”
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N-alkylaryl styrylcyanine dyes as fluorescent probes for nucleic acids detection by Kuperman, M. V., Snihirova, Y. V., Kryvorotenko, D. V., Losytskyy, M. Yu, Kovalska, V. B., Yarmoluk, S. M.

“…Aim. To synthesize and characterize a series of N-alkylaryl benzothiazole styrylcyanine dyes as potential fluorescent probes for nucleic acids (NA) detection…”
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Interaction of cyanine dyes with nucleic acids. XVIII. Formation of the carbocyanine dye J-aggregates in nucleic acid grooves by Ogul'chansky, T.Yu, Losytskyy, M.Yu, Kovalska, V.B, Lukashov, S.S, Yashchuk, V.M, Yarmoluk, S.M

“…Spectral properties of carbocyanine dye 3-methyl-2-[3-methyl-2-(3-methyl-2,3-dihydro-1,3-benzothiazole-2-iliden)-1-butenyl]-1,3-benzothiazole-3-il iodide (Cyan…”
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Design of 4-(4-dialkylaminostyryl) -pyridinium dyes for fluorescent detection of amyloid fibrils by Inshyn, D. I., Chernii, S. V., Kovalska, V. B., Yarmoluk, S. M.

“…The pathological proteins aggregation into the fibrillar structures is common to a large group of amyloid-related disorders, such as neurodegenerative…”
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Studies on the spectral-luminescent properties of the novel homodimer styryl dyes in complexes with DNA by Kovalska, V B, Kocheshev, I O, Kryvorotenko, D V, Balanda, A, Yarmoluk, S M

“…Series of homodimer styryls containing on (p-dimethylaminostyryl) pyridinium residues that are connected with aliphatic linkage group was synthesized. Spectral…”
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Interaction of cyanine dyes with nucleic acids. XXV. Influence of affinity-modifying groups in the structure of benzothiazol-4-[2,6-dimethylpyridinium] dyes on the spectral properties of the dyes in the presence of nucleic acids by Yarmoluk, S.M, Kovalska, V.B, Kryvorotenko, D.V, Balanda, A.O, Ogul'chansky, T.Yu

“…Novel monomethine pyridinium cyanine dyes of similar structure and containing ‘affinity-modifying’ groups of different chemical nature were studied by…”
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Application of MALDI-TOF mass spectrometry for study on fibrillar and oligomeric aggregates of alpha-synuclein by Severinovskaya, O. V., Kovalska, V. B., Losytskyy, M. Yu, Cherepanov, V. V., Subramaniam, V., Yarmoluk, S. M.

“…Aim. To study the -synuclein (ASN) aggregates of different structural origin, namely amyloid fibrils and spherical oligomers, in comparison with a native…”
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The Mechanism of Benzothiazole Styrylcyanine Dyes Binding with dsDNA: Studies by Spectral-Luminescent Methods by Akbay, N., Losytskyy, M. Yu, Kovalska, V. B., Balanda, A. O., Yarmoluk, S. M.

“…In the presented work studies of the interaction mode of monomer and two homodimer benzothiazole styryl dyes containing spermine-like linkage/tail group with…”
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