Search Results - "Kovalska, Maria"

Blood and Brain Metabolites after Cerebral Ischemia by Baranovicova, Eva, Kalenska, Dagmar, Kaplan, Peter, Kovalska, Maria, Tatarkova, Zuzana, Lehotsky, Jan

“…The study of an organism's response to cerebral ischemia at different levels is essential to understanding the mechanism of the injury and protection. A great…”
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Methionine Diet Evoked Hyperhomocysteinemia Causes Hippocampal Alterations, Metabolomics Plasma Changes and Behavioral Pattern in Wild Type Rats by Kovalska, Maria, Baranovicova, Eva, Kalenska, Dagmar, Tomascova, Anna, Adamkov, Marian, Kovalska, Libusa, Lehotsky, Jan

“…L-methionine, an essential amino acid, plays a critical role in cell physiology. High intake and/or dysregulation in methionine (Met) metabolism results in…”
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Mechanisms Involved in the Ischemic Tolerance in Brain: Effect of the Homocysteine by Lehotsky, Jan, Petras, Martin, Kovalska, Maria, Tothova, Barbara, Drgova, Anna, Kaplan, Peter

“…Hyperhomocysteinemia (hHCy) is recognized as a co-morbid risk factor of human stroke. It also aggravates the ischemia-induced injury by increased production of…”
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Alzheimer’s Disease-like Pathological Features in the Dorsal Hippocampus of Wild-Type Rats Subjected to Methionine-Diet-Evoked Mild Hyperhomocysteinaemia by Kovalska, Maria, Hnilicova, Petra, Kalenska, Dagmar, Adamkov, Marian, Kovalska, Libusa, Lehotsky, Jan

“…Multifactorial interactions, including nutritional state, likely participate in neurodegeneration’s pathogenesis and evolution. Dysregulation in methionine…”
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Effect of Methionine Diet on Time-Related Metabolic and Histopathological Changes of Rat Hippocampus in the Model of Global Brain Ischemia by Kovalska, Maria, Hnilicova, Petra, Kalenska, Dagmar, Tomascova, Anna, Adamkov, Marian, Lehotsky, Jan

“…Hyperhomocysteinemia (hHcy) represents a strong risk factor for atherosclerosis-associated diseases, like stroke, dementia or Alzheimer's disease. A methionine…”
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Dynamics in Redox-Active Molecules Following Ischemic Preconditioning in the Brain by Lysikova, Terezia, Tomascova, Anna, Kovalska, Maria, Lehotsky, Jan, Leskova Majdova, Katarina, Kaplan, Peter, Tatarkova, Zuzana

“…It is well known that the brain is quite vulnerable to oxidative stress, initiating neuronal loss after ischemia-reperfusion (IR) injury. A potent protective…”
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Metabolic Changes Induced by Cerebral Ischemia, the Effect of Ischemic Preconditioning, and Hyperhomocysteinemia by Baranovicova, Eva, Hnilicova, Petra, Kalenska, Dagmar, Kaplan, Peter, Kovalska, Maria, Tatarkova, Zuzana, Tomascova, Anna, Lehotsky, Jan

“…H Nuclear Magnetic Resonance (NMR) metabolomics is one of the fundamental tools in the fast-developing metabolomics field. It identifies and quantifies the…”
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Survivin expression in breast lobular carcinoma: Correlations with normal breast tissue and clinicomorphological parameters by Adamkov, Marian, Výbohová, Desanka, Horáček, Jaroslav, Kovalská, Mária, Furjelová, Martina

“…The antiapoptotic protein survivin is rarely expressed in normal adult differentiated tissues, but it is often detected in their malignant counterparts…”
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Role of Homocysteine in the Ischemic Stroke and Development of Ischemic Tolerance by Lehotský, Ján, Tothová, Barbara, Kovalská, Maria, Dobrota, Dušan, Beňová, Anna, Kalenská, Dagmar, Kaplán, Peter

“…Homocysteine (Hcy) is a toxic, sulfur-containing intermediate of methionine metabolism. Hyperhomocysteinemia (hHcy), as a consequence of impaired Hcy…”
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Hippocampal metabolic recovery as a manifestation of the protective effect of ischemic preconditioning in rats by Baranovicova, Eva, Kalenska, Dagmar, Kovalska, Maria, Lehotsky, Jan

“…The ever-present risk of brain ischemic events in humans and its full prevention make the detailed studies of an organism's response to ischemia at different…”
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Involvement of Proteasomal and Endoplasmic Reticulum Stress in Neurodegeneration After Global Brain Ischemia by Ziakova, Katarina, Kovalska, Maria, Pilchova, Ivana, Dibdiakova, Katarina, Brodnanova, Maria, Pokusa, Michal, Kalenska, Dagmar, Racay, Peter

“…A brief period of transient global brain ischemia leads to selective ischemic neurodegeneration associated with death of hippocampal CA1 pyramidal neurons days…”
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Association of Induced Hyperhomocysteinemia with Alzheimer’s Disease-Like Neurodegeneration in Rat Cortical Neurons After Global Ischemia-Reperfusion Injury by Kovalska, Maria, Tothova, Barbara, Kovalska, Libusa, Tatarkova, Zuzana, Kalenska, Dagmar, Tomascova, Anna, Adamkov, Marian, Lehotsky, Jan

“…Alzheimer’s disease (AD) is a progressive and irreversible neurodegenerative disorder that results in massive hippocampal and neocortical neuronal loss leading…”
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Global brain ischemia in rats is associated with mitochondrial release and downregulation of Mfn2 in the cerebral cortex, but not the hippocampus by Klacanova, Katarina, Kovalska, Maria, Chomova, Maria, Pilchova, Ivana, Tatarkova, Zuzana, Kaplan, Peter, Racay, Peter

“…Mitochondria are crucial for neuronal cell survival and death through their functions in ATP production and the intrinsic pathway of apoptosis. Mitochondrial…”
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Effect of Methionine Diet on Metabolic and Histopathological Changes of Rat Hippocampus by Kovalska, Maria, Hnilicova, Petra, Kalenska, Dagmar, Tothova, Barbara, Adamkov, Marian, Lehotsky, Jan

“…Hyperhomocysteinemia (hHcy) is regarded as an independent and strong risk factor for cerebrovascular diseases, stroke, and dementias. The hippocampus has a…”
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The Effect of Aging on Mitochondrial Complex I and the Extent of Oxidative Stress in the Rat Brain Cortex by Tatarkova, Zuzana, Kovalska, Maria, Timkova, Veronika, Racay, Peter, Lehotsky, Jan, Kaplan, Peter

“…One of the characteristic features of the aging is dysfunction of mitochondria. Its role in the regulation of metabolism and apoptosis suggests a possible link…”
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Intracellular Signaling MAPK Pathway After Cerebral Ischemia–Reperfusion Injury by Kovalska, Maria, Kovalska, Libusa, Pavlikova, Martina, Janickova, Maria, Mikuskova, Katarina, Adamkov, Marian, Kaplan, Peter, Tatarkova, Zuzana, Lehotsky, Jan

“…The MAPK/ERK/p38 are signal transduction pathways that couple intracellular responses to the external stimuli. Contrary to ERK protein which is part of the…”
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Tyrosine nitration of mitochondrial proteins during myocardial ischemia and reperfusion by Tatarkova, Zuzana, Kovalska, Maria, Sivonova, Monika Kmetova, Racay, Peter, Lehotsky, Jan, Kaplan, Peter

“…Myocardial ischemia reperfusion is associated with mitochondrial dysfunction and increased formation of reactive oxygen/nitrogen species. The main purpose of…”
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Histone Hyperacetylation as a Response to Global Brain Ischemia Associated with Hyperhomocysteinemia in Rats by Tóthová, Barbara, Kovalská, Mária, Kalenská, Dagmar, Tomašcová, Anna, Lehotský, Ján

“…Epigenetic regulations play an important role in both normal and pathological conditions of an organism, and are influenced by various exogenous and endogenous…”
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Neuroprotection exerted by ischemic preconditioning in rat hippocampus involves extracellular signal receptor changes by Lehotsky, Jan, Kovalska, Maria, Tothova, Barbara, Tatarkova, Zuzana, Kaplan, Peter

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Role of homocysteine in the ischemic stroke nad development of ischemic tolerance by Jan Lehotsky, Barbara Tothova, Maria Kovalska, Maria Kovalska, Dusan Dobrota, Anna Beňová, Dagmar Kalenska, Peter Kaplan

“…Homocysteine (Hcy) is a toxic, sulfur-containing intermediate of methionine metabolism. Hyperhomocysteinemia (hHcy), as a consequence of impaired Hcy…”
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