Search Results - "Kovalovsky, Damián"

Activation and Induction of NUR77/NURR1 in Corticotrophs by CRH/cAMP: Involvement of Calcium, Protein Kinase A, and MAPK Pathways by Kovalovsky, Damián, Refojo, Damián, Liberman, Ana Clara, Hochbaum, Daniel, Pereda, Marcelo Paez, Coso, Omar A, Stalla, Günter K, Holsboer, Florian, Arzt, Eduardo

“…Nur factors are critical for proopiomelanocortin (POMC) induction by CRH in corticotrophs, but the pathways linking CRH to Nur are unknown. In this study we…”
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From Hematopoietic Stem Cell Transplantation to Chimeric Antigen Receptor Therapy: Advances, Limitations and Future Perspectives by Voynova, Elisaveta, Kovalovsky, Damian

“…Chimeric antigen receptor (CAR) T-cell therapy was envisioned as a mechanism to re-direct effector T-cells to eliminate tumor cells. CARs are composed of the…”
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Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia by Kovalovsky, Damian, Yoon, Jeong Heon, Cyr, Matthew G., Simon, Samantha, Voynova, Elisaveta, Rader, Christoph, Wiestner, Adrian, Alejo, Julie, Pittaluga, Stefania, Gress, Ronald E.

“…The only current curative treatment for chronic lymphocytic leukemia (CLL) is allogenic hematopoietic stem cell transplantation. Chimeric antigen receptor…”
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Zbtb1 Safeguards Genome Integrity and Prevents p53-Mediated Apoptosis in Proliferating Lymphoid Progenitors by Cao, Xin, Lu, Ying, Zhang, Xianyu, Kovalovsky, Damian

“…Expression of the transcription factor Zbtb1 is required for normal lymphoid development. We report in the present study that Zbtb1 maintains genome integrity…”
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Safety and clinical activity of PD-L1 blockade in patients with aggressive recurrent respiratory papillomatosis by Allen, Clint T, Lee, Sunmin, Norberg, Scott M, Kovalovsky, Damian, Ye, Hong, Clavijo, Paul E, Hu-Lieskovan, Siwen, Schlegel, Richard, Schlom, Jeffrey, Strauss, Julius, Gulley, James L, Trepel, Jane, Hinrichs, Christian S

“…Recurrent respiratory papillomatosis (RRP) is a human papillomavirus (HPV)-driven disorder that causes substantial morbidity and can lead to fatal distal…”
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A novel TCR transgenic model reveals that negative selection involves an immediate, Bim-dependent pathway and a delayed, Bim-independent pathway by Kovalovsky, Damian, Pezzano, Mark, Ortiz, Benjamin D, Sant'Angelo, Derek B

“…A complete understanding of negative selection has been elusive due to the rapid apoptosis and clearance of thymocytes in vivo. We report a TCR transgenic…”
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Ectopic T cell receptor-α locus control region activity in B cells is suppressed by direct linkage to two flanking genes at once by Knirr, Stefan, Gomos-Klein, Janette, Andino, Blanca E, Harrow, Faith, Erhard, Karl F, Kovalovsky, Damian, Sant'Angelo, Derek B, Ortiz, Benjamin D

“…The molecular mechanisms regulating the activity of the TCRα gene are required for the production of the circulating T cell repertoire. Elements of the mouse…”
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Adaptable TCR Avidity Thresholds for Negative Selection by Stojakovic, Milica, Salazar-Fontana, Laura I, Tatari-Calderone, Zohreh, Badovinac, Vladimir P, Santori, Fabio R, Kovalovsky, Damian, Sant'Angelo, Derek, Harty, John T, Vukmanovic, Stanislav

“…Central tolerance plays a significant role in preventing autoimmune diseases by eliminating T cells with high and intermediate avidity for self. To determine…”
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Activation and induction of NUR77/NURR1 in corticotrophs by CRH/cAMP: involvement of calcium, protein kinase A, and MAPK pathways by Kovalovsky, Damián, Refojo, Damián, Liberman, Ana Clara, Hochbaum, Daniel, Pereda, Marcelo Paez, Coso, Omar A, Stalla, Günter K, Holsboer, Florian, Arzt, Eduardo

“…Nur factors are critical for proopiomelanocortin (POMC) induction by CRH in corticotrophs, but the pathways linking CRH to Nur are unknown. In this study we…”
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PLZF Controls the Development of Fetal-Derived IL-17+V gamma 6+ gamma delta T Cells by Lu, Ying, Cao, Xin, Zhang, Xianyu, Kovalovsky, Damian

“…Expression of promyelocytic leukemia zinc finger (PLZF) protein directs the effector differentiation of invariant NKT (iNKT) cells and IL-4+ gamma delta NKT…”
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Nur77 induction and activation are necessary for interleukin-1 stimulation of proopiomelanocortin in AtT-20 corticotrophs by Kovalovsky, Damian, Paez Pereda, Marcelo, Labeur, Marta, Renner, Ulrich, Holsboer, Florian, Stalla, Günter K, Arzt, Eduardo

“…Nur77 and Nurr1 are critical for proopiomelanocortin (POMC) regulation by corticotrophin releasing hormone (CRH) in corticotrophs. We analyze the regulation…”
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Molecular mechanisms and Th1/Th2 pathways in corticosteroid regulation of cytokine production by Kovalovsky, Damián, Refojo, Damián, Holsboer, Florian, Arzt, Eduardo

“…We focus on how the IL-1 system, T-helper1 (Th1) or Th2 cytokines and glucocorticoids, converge to give a unified physiological response. Glucocorticoids…”
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Expression of a BTB-ZF transcription factor controls the function of an innate-like Tregs essential for intestinal homeostasis by Krzyzanowska, Agata K, Haynes, Rashade A, Kovalovsky, Damian, Lin, Hsinching, Edelblum, Karen L, Corcoran, Lynn M, Rabson, Arnold B, Denzin, Lisa K, Sant’Angelo, Derek B

“…Abstract The BTB-ZF genes are a family of 49 transcription factors that control the lineage specification and development of key effector functions of…”
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The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions by Hobbs, Robin M, Im, Jin S, Sant'Angelo, Derek B, Kim, Hye-Jung, Yi, Woelsung, Alonzo, Eric, Pandolfi, Pier Paolo, Uche, Olisambu U, Eladad, Sonia, Chua, Kevin, Eidson, Maggie, Kovalovsky, Damian

“…Invariant natural killer cells recognize glycolipids presented by CD1d molecules and can mediate rapid innate responses. Sant'Angelo and colleagues show that…”
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Specific expression of a BTB-ZF transcription factor defines innate-like regulatory T cells that are essential for intestinal homeostasis by Krzyzanowska, Agata K, Haynes, Rashade A, Kovalovsky, Damian, Edelblum, Karen L, Corcoran, Lynn M, Rabson, Arnold B, Denzin, Lisa K, Sant'Angelo, Derek B

“…Abstract Regulatory T cells (Tregs) play a pivotal role in regulating immune responses and are a significant source of the anti-inflammatory cytokine IL-10 in…”
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Zbtb-1 controls NKp46+RORgammat+ innate lymphoid cell (ILC3) development by Lu, Ying, Zhang, Xianyu, Bouladoux, Nicolas, Belkaid, Yasmine, kovalovsky, Damian

“…Abstract Innate lymphoid cells (ILCs) play a central role in conferring protective immunity at the mucosal frontier. We identified a new function of the…”
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PLZF Controls the Development of Fetal-Derived IL-17+Vγ6+ γδ T Cells by Lu, Ying, Cao, Xin, Zhang, Xianyu, Kovalovsky, Damian

“…Expression of promyelocytic leukemia zinc finger (PLZF) protein directs the effector differentiation of invariant NKT (iNKT) cells and IL-4(+) γδ NKT cells. In…”
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Zbtb1 prevents default myeloid differentiation of lymphoid-primed multipotent progenitors by Zhang, Xianyu, Lu, Ying, Cao, Xin, Zhen, Tao, Kovalovsky, Damian

“…Zbtb1 is a transcription factor that prevents DNA damage and p53-mediated apoptosis in replicating immune progenitors, affecting lymphoid as well as myeloid…”
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Increased Activity of a NK-Specific CAR-NK Framework Targeting CD3 and CD5 for T-Cell Leukemias by Voynova, Elisaveta, Hawk, Nga, Flomerfelt, Francis A, Telford, William G, Gress, Ronald E, Kanakry, Jennifer A, Kovalovsky, Damian

“…NK effector cells expressing a CAR construct may be used to target T-lineage markers. In this work, we compared the activity of a NK-specific CAR-NK and a…”
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The HDAC6 inhibitor AVS100 (SS208) induces a pro-inflammatory tumor microenvironment and potentiates immunotherapy by Kovalovsky, Damian, Noonepalle, Satish, Suresh, Manasa, Kumar, Dileep, Berrigan, Michael, Gajendran, Nithya, Upadhyay, Sumit, Horvath, Anelia, Kim, Allen, Quiceno-Torres, David, Musunuri, Karthik, Villagra, Alejandro

“…Histone deacetylase 6 (HDAC6) inhibition is associated with an increased pro-inflammatory tumor microenvironment and antitumoral immune responses. Here, we…”
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