Structural and Functional Properties of Amylose Complexes with Genistein

Complexes of amylose or high-amylose corn starch (HACS) with genistein were prepared by the acidification of an alkali solution to yield a V6ΙΙΙ structure. The amylose−genistein complexes exhibited significantly higher genistein content (11 mg/100 mg of complex) than HACS−genistein complexes (9 mg/1...

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Bibliographic Details
Published in:	Journal of agricultural and food chemistry Vol. 56; no. 11; pp. 4212 - 4218
Main Authors:	Cohen, Revital, Orlova, Yevgenia, Kovalev, Marina, Ungar, Yael, Shimoni, Eyal
Format:	Journal Article
Language:	English
Published:	Washington, DC American Chemical Society 11-06-2008
Subjects:	amylose Amylose - analysis Amylose - chemistry Biological and medical sciences Digestion Drug Stability Food Chemistry/Biochemistry Food industries Fundamental and applied biological sciences. Psychology genistein Genistein - analysis Genistein - chemistry Genistein - metabolism Hot Temperature Hydrogen-Ion Concentration Isoflavones nanoencapsulation Pancreatin - metabolism Particle Size slow release Solutions starch Starch and starchy product industries Structure-Activity Relationship X-Ray Diffraction nanoencapsulation amylose starch genistein Isoflavones slow release Isoflavone Starch Genistein Properties Flavonoid Phytoestrogen Polyphenol Amylose Carbohydrate Polysaccharide Release
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Summary:	Complexes of amylose or high-amylose corn starch (HACS) with genistein were prepared by the acidification of an alkali solution to yield a V6ΙΙΙ structure. The amylose−genistein complexes exhibited significantly higher genistein content (11 mg/100 mg of complex) than HACS−genistein complexes (9 mg/100 mg of complex). The effect of genistein on the amylose complexes was examined in different genistein−amylose ratios, and a model for genistein organization in the amylose complexes was suggested. The complexes were stable at different pH values, with <10% of the complexed genistein released, and were stable at 30 and 50 °C. Lower stability was observed at 80 °C as shown by the extensive release of genistein. All complexes showed high retention of genistein in simulated stomach conditions and released genistein upon digestion in pancreatin solution. It is therefore suggested that the complexes can be used as carriers for the slow release of genistein.
Bibliography:	The research was supported by Russell Berrie Nanotechnology Institute, TechnionIsrael Institute of Technology (Israel). ark:/67375/TPS-SWDQDC3B-L istex:724E1DB6203910B59054F5FC1FFB2F091053D130 ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0021-8561 1520-5118
DOI:	10.1021/jf800255c