Search Results - "Kovalenko, Elena I"

HSP70 Multi-Functionality in Cancer by Albakova, Zarema, Armeev, Grigoriy A, Kanevskiy, Leonid M, Kovalenko, Elena I, Sapozhnikov, Alexander M

“…The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing malignant cells selective advantage by suppressing multiple apoptotic…”
Get full text

Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation by Palamarchuk, Anastasia I, Kovalenko, Elena I, Streltsova, Maria A

“…Telomerase reverse transcriptase (TERT), a core part of telomerase, has been known for a long time only for its telomere lengthening function by reverse…”
Get full text

Analysis of NK cell clones obtained using interleukin-2 and gene-modified K562 cells revealed the ability of "senescent" NK cells to lose CD57 expression and start expressing NKG2A by Streltsova, Maria A, Erokhina, Sofya A, Kanevskiy, Leonid M, Lee, Dean A, Telford, William G, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…In this work, we analyzed the phenotype and growth of human NK cell clones obtained by the stimulation of individual NK cells with IL-2 and gene-modified K562…”
Get full text

The Biological Role and Therapeutic Potential of NK Cells in Hematological and Solid Tumors by Velichinskii, Rodion A, Streltsova, Maria A, Kust, Sofya A, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…NK cells are an attractive target for cancer immunotherapy due to their potent antitumor activity. The main advantage of using NK cells as cytotoxic effectors…”
Get full text

Similarity and Differences in Inflammation-Related Characteristics of the Peripheral Immune System of Patients with Parkinson's and Alzheimer's Diseases by Boyko, Anna A, Troyanova, Natalya I, Kovalenko, Elena I, Sapozhnikov, Alexander M

“…Parkinson's disease (PD) and Alzheimer's disease (AD) are the most common age-related neurodegenerative disorders. Both diseases are characterized by chronic…”
Get full text

HLA-DR-Positive NK Cells Expand in Response to Mycobacterium Tuberculosis Antigens and Mediate Mycobacteria-Induced T Cell Activation by Kust, Sofya A, Streltsova, Maria A, Panteleev, Alexander V, Karpina, Natalya L, Lyadova, Irina V, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…NK cells play an important role in the control of tuberculosis infection: they are not only able to kill the infected cells, but also control the activity of…”
Get full text

HLA-DR Expression in Natural Killer Cells Marks Distinct Functional States, Depending on Cell Differentiation Stage by Kust, Sofya A, Ustiuzhanina, Maria O, Streltsova, Maria A, Shelyakin, Pavel V, Kryukov, Maxim A, Lutsenko, Gennady V, Sudarikova, Anna V, Merzlyak, Ekaterina M, Britanova, Olga V, Sapozhnikov, Alexandr M, Kovalenko, Elena I

“…HLA-DR-positive NK cells, found in both healthy individuals and patients with different inflammatory diseases, are characterized as activated cells. However,…”
Get full text

The hTERT and iCasp9 Transgenes Affect EOMES and T-BET Levels in NK Cells and the Introduction of Both Genes Improves NK Cell Proliferation in Response to IL2 and IL15 Stimulation by Palamarchuk, Anastasia I, Kovalenko, Elena I, Streltsova, Maria A

“…The NK cell exhaustion state evolving during extensive and prolonged cultivation is still one of the limitations of NK cell approaches. In this research, we…”
Get full text

Reduced Immunosenescence of Peripheral Blood T Cells in Parkinson's Disease with CMV Infection Background by Vavilova, Julia D, Boyko, Anna A, Ponomareva, Natalya V, Fokin, Vitaly F, Fedotova, Ekaterina Y, Streltsova, Maria A, Kust, Sofya A, Grechikhina, Maria V, Bril, Ekaterina V, Zimnyakova, Olga S, Kovalenko, Elena I, Sapozhnikov, Alexander M

“…Immunosenescence is a process of remodeling the immune system under the influence of chronic inflammation during aging. Parkinson's disease (PD) is a common…”
Get full text

Coordinated Loss and Acquisition of NK Cell Surface Markers Accompanied by Generalized Cytokine Dysregulation in COVID-19 by Ustiuzhanina, Maria O, Vavilova, Julia D, Boyko, Anna A, Streltsova, Maria A, Kust, Sofya A, Kanevskiy, Leonid M, Sapozhnikov, Alexander M, Iskhakov, Rustam N, Gubernatorova, Ekaterina O, Drutskaya, Marina S, Bychinin, Mikhail V, Zhukova, Oksana A, Novikova, Oksana N, Sotnikova, Anna G, Yusubalieva, Gaukhar M, Baklaushev, Vladimir P, Kovalenko, Elena I

“…Coronavirus disease 2019 (COVID-19), caused by the SARS-CoV-2 virus, is accompanied by a dysregulated immune response. In particular, NK cells, involved in the…”
Get full text

Alterations in the CD56 - and CD56 + T Cell Subsets during COVID-19 by Vavilova, Julia D, Ustiuzhanina, Maria O, Boyko, Anna A, Streltsova, Maria A, Kust, Sofya A, Kanevskiy, Leonid M, Iskhakov, Rustam N, Sapozhnikov, Alexander M, Gubernatorova, Ekaterina O, Drutskaya, Marina S, Bychinin, Mikhail V, Novikova, Oksana N, Sotnikova, Anna G, Yusubalieva, Gaukhar M, Baklaushev, Vladimir P, Kovalenko, Elena I

“…The effectiveness of the antiviral immune response largely depends on the activation of cytotoxic T cells. The heterogeneous group of functionally active T…”
Get full text

Lipopolysaccharide induces IFN-γ production in human NK cells by Kanevskiy, Leonid M, Telford, William G, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…Natural killer (NK) cells have been shown to play a regulatory role in sepsis. According to the current view, NK cells become activated via macrophages or…”
Get full text

Increased Susceptibility of the CD57 - NK Cells Expressing KIR2DL2/3 and NKG2C to iCasp9 Gene Retroviral Transduction and the Relationships with Proliferative Potential, Activation Degree, and Death Induction Response by Palamarchuk, Anastasia I, Alekseeva, Nadezhda A, Streltsova, Maria A, Ustiuzhanina, Maria O, Kobyzeva, Polina A, Kust, Sofya A, Grechikhina, Maria V, Boyko, Anna A, Shustova, Olga A, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…Nowadays, the use of genetically modified NK cells is a promising strategy for cancer immunotherapy. The additional insertion of genes capable of inducing cell…”
Get full text

Surface NKG2C Identifies Differentiated αβT-Cell Clones Expanded in Peripheral Blood by Kovalenko, Elena I, Zvyagin, Ivan V, Streltsova, Maria A, Mikelov, Artem I, Erokhina, Sofya A, Telford, William G, Sapozhnikov, Alexander M, Lebedev, Yury B

“…T cells that express CD56 in peripheral blood of healthy humans represent a heterogeneous and poorly studied subset. In this work, we analyzed this subset for…”
Get full text

Epithelial-Immune Cell Crosstalk Determines the Activation of Immune Cells In Vitro by the Human Cathelicidin LL-37 at Low Physiological Concentrations by Bogdanov, Ivan V, Streltsova, Maria A, Kovalenko, Elena I, Sapozhnikov, Alexander M, Panteleev, Pavel V, Ovchinnikova, Tatiana V

“…The only human cathelicidin, LL-37, is a host defense antimicrobial peptide with antimicrobial activities against protozoans, fungi, Gram(+) and Gram(−)…”
Get full text

Recurrent Stimulation of Natural Killer Cell Clones with K562 Expressing Membrane-Bound Interleukin-21 Affects Their Phenotype, Interferon-γ Production, and Lifespan by Streltsova, Maria A, Erokhina, Sofya A, Kanevskiy, Leonid M, Grechikhina, Maria V, Kobyzeva, Polina A, Lee, Dean A, Telford, William G, Sapozhnikov, Alexander M, Kovalenko, Elena I

“…A pattern of natural killer cell (NK cell) heterogeneity determines proliferative and functional responses to activating stimuli in individuals. Obtaining the…”
Get full text

Obtaining Gene-Modified HLA-E-Expressing Feeder Cells for Stimulation of Natural Killer Cells by Alekseeva, Nadezhda A, Streltsova, Maria A, Vavilova, Julia D, Ustiuzhanina, Maria O, Palamarchuk, Anastasia I, Boyko, Anna A, Timofeev, Nikita D, Popodko, Alexey I, Kovalenko, Elena I

“…Human cytomegalovirus (HCMV)-specific adaptive NK cells are capable of recognizing viral peptides presented by HLA-E on infected cells via the NKG2C receptor…”
Get full text

Autologous T-Cell-Free Antigen Presentation System Unveils hCMV-Specific NK Cell Response by Ustiuzhanina, Maria O, Streltsova, Maria A, Timofeev, Nikita D, Kryukov, Maxim A, Chudakov, Dmitriy M, Kovalenko, Elena I

“…NK cells play a decisive role in controlling hCMV infection by combining innate and adaptive-like immune reactions. The hCMV-derived VMAPRTLFL (LFL) peptide is…”
Get full text

Three-Dimensional Model Analysis Revealed Differential Cytotoxic Effects of the NK-92 Cell Line and Primary NK Cells on Breast and Ovarian Carcinoma Cell Lines Mediated by Variations in Receptor-Ligand Interactions and Soluble Factor Profiles by Alekseeva, Nadezhda A, Boyko, Anna A, Shevchenko, Marina A, Grechikhina, Maria V, Streltsova, Maria A, Alekseeva, Ludmila G, Sapozhnikov, Alexander M, Deyev, Sergey M, Kovalenko, Elena I

“…The functional activity of a certain tumor determines the effectiveness of primary NK cells and NK-92 cell line-based cancer therapy; their therapeutic…”
Get full text

Targeted Delivery of HSP70 to Tumor Cells via Supramolecular Complex Based on HER2-Specific DARPin9_29 and the Barnase:Barstar Pair by Alekseeva, Ludmila G, Ovsyanikova, Olga V, Schulga, Alexey A, Grechikhina, Maria V, Shustova, Olga A, Kovalenko, Elena I, Svirshchevskaya, Elena V, Deyev, Sergey M, Sapozhnikov, Alexander M

“…(1) Background: We have previously shown that the use of an artificial supramolecular two-component system based on chimeric recombinant proteins…”
Get full text