Dataset on safety and protective efficacy studies of COVID-19 vaccine candidates based on structurally modified plant virus in female hamsters

This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses’ S protei...

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Bibliographic Details
Published in:	Data in brief Vol. 48; p. 109158
Main Authors:	Kovalenko, A.O., Ryabchevskaya, E.M., Evtushenko, E.A., Kondakova, O.A., Ivanov, P.A., Arkhipenko, M.V., Nikitin, N.A., Karpova, O.V.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-06-2023 Published by Elsevier Inc Elsevier
Subjects:	COVID-19 Data Lung histological studies Preclinical study Spherical particles Structurally modified plant virus Vaccine Vaccine protective efficacy COVID-19 Lung histological studies Structurally modified plant virus Spherical particles Preclinical study Vaccine Vaccine protective efficacy
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Summary:	This data article is related to the previous research, which addressed the development of a COVID-19 recombinant vaccine candidate. Here, we present the additional data in support of the safety and protective efficacy evaluation of two COVID-19 vaccine candidates based on the coronaviruses’ S protein fragments and a structurally modified plant virus – spherical particles. The effectiveness of the experimental vaccines was studied against the SARS-CoV-2 virus in an in vivo infection model in female Syrian hamsters. The body weight of vaccinated laboratory animals was monitored. The histological assessment data of the infected with the SARS-CoV-2 virus hamsters’ lungs are provided. [Display omitted]
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work and share first authorship
ISSN:	2352-3409 2352-3409
DOI:	10.1016/j.dib.2023.109158