Search Results - "Kovacs, Elizabeth J."

Macrophage phagocytosis: effects of environmental pollutants, alcohol, cigarette smoke, and other external factors by Karavitis, John, Kovacs, Elizabeth J.

“…Review of the mechanisms by which external factors, such as alcohol, cigarette smoke, air pollution, and others impact macrophage phagocytosis. The ability of…”
Get full text

The systemic immune response to trauma: an overview of pathophysiology and treatment by Lord, Janet M, Prof, Midwinter, Mark J, Prof, Chen, Yen-Fu, PhD, Belli, Antonio, MD, Brohi, Karim, Prof, Kovacs, Elizabeth J, Prof, Koenderman, Leo, Prof, Kubes, Paul, Prof, Lilford, Richard J, Prof

“…Summary Improvements in the control of haemorrhage after trauma have resulted in the survival of many people who would otherwise have died from the initial…”
Get full text

Extracellular traps and macrophages: new roles for the versatile phagocyte by Boe, Devin M., Curtis, Brenda J., Chen, Michael M., Ippolito, Jill A., Kovacs, Elizabeth J.

“…Review on macrophage regulation and extracellular traps: implications in health and disease. MΦ are multipurpose phagocytes with a large repertoire of…”
Get full text

Advanced age impairs macrophage polarization by Mahbub, Shegufta, Deburghgraeve, Cory R, Kovacs, Elizabeth J

“…Aging affects many aspects of the cellular function of macrophages. Macrophages play a critical role in innate immunity, acting as sentinels to fight…”
Get more information

Chronic wound repair and healing in older adults: Current status and future research by Gould, Lisa, Abadir, Peter, Brem, Harold, Carter, Marissa, Conner-Kerr, Teresa, Davidson, Jeff, DiPietro, Luisa, Falanga, Vincent, Fife, Caroline, Gardner, Sue, Grice, Elizabeth, Harmon, John, Hazzard, William R., High, Kevin P., Houghton, Pamela, Jacobson, Nasreen, Kirsner, Robert S., Kovacs, Elizabeth J., Margolis, David, McFarland Horne, Frances, Reed, May J., Sullivan, Dennis H., Thom, Stephen, Tomic-Canic, Marjana, Walston, Jeremy, Whitney, JoAnne, Williams, John, Zieman, Susan, Schmader, Kenneth

“…The incidence of chronic wounds is increased among older adults, and the impact of chronic wounds on quality of life is particularly profound in this…”
Get full text

An Official American Thoracic Society Workshop Report: Evaluation and Management of Asthma in the Elderly by Skloot, Gwen S, Busse, Paula J, Braman, Sidney S, Kovacs, Elizabeth J, Dixon, Anne E, Vaz Fragoso, Carlos A, Scichilone, Nicola, Prakash, Y S, Pabelick, Christina M, Mathur, Sameer K, Hanania, Nicola A, Moore, Wendy C, Gibson, Peter G, Zieman, Susan, Ragless, Betina B

“…Asthma in the elderly (>65 yr old) is common and associated with higher morbidity and mortality than asthma in younger patients. The poor outcomes in this…”
Get full text

Aging and innate immune cells by Plackett, Timothy P., Boehmer, Eric D., Faunce, Douglas E., Kovacs, Elizabeth J.

“…The innate immune system serves an important role in preventing microbial invasion. However, it experiences significant changes with advancing age. Among the…”
Get full text

Inhibition of long myosin light-chain kinase activation alleviates intestinal damage after binge ethanol exposure and burn injury by Zahs, Anita, Bird, Melanie D, Ramirez, Luis, Turner, Jerrold R, Choudhry, Mashkoor A, Kovacs, Elizabeth J

“…Laboratory evidence suggests that intestinal permeability is elevated following either binge ethanol exposure or burn injury alone, and this barrier…”
Get more information

Inflammaging and the Lung by Kovacs, Elizabeth J., PhD, Boe, Devin M., BA, Boule, Lisbeth A., PhD, Curtis, Brenda J., PhD

“…With the coming of the “silver tsunami,” expanding the knowledge about how various intrinsic and extrinsic factors affect the immune system in the elderly is…”
Get full text

Ethanol Intoxication Impairs Respiratory Function and Bacterial Clearance and Is Associated With Neutrophil Accumulation in the Lung After Streptococcus pneumoniae Infection by Hulsebus, Holly J, Najarro, Kevin M, McMahan, Rachel H, Boe, Devin M, Orlicky, David J, Kovacs, Elizabeth J

“…Alcohol consumption is commonplace in the United States and its prevalence has increased in recent years. Excessive alcohol use is linked to an increased risk…”
Get full text

Aging and innate immunity in the mouse: impact of intrinsic and extrinsic factors by Kovacs, Elizabeth J, Palmer, Jessica L, Fortin, Carl F, Fülöp, Tamas, Goldstein, Daniel R, Linton, Phyllis-Jean

“…Aging affects every innate immune cell, including changes in cell numbers and function. Defects in the function of some cells are intrinsic, whereas for other…”
Get full text

A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age by McMahan, Rachel H, Najarro, Kevin M, Mullen, Juliet E, Paul, Madison T, Orlicky, David J, Hulsebus, Holly J, Kovacs, Elizabeth J

“…There are currently > 600 million people over the age of 65 globally and this number is expected to double by the year 2050. Alcohol use among this population…”
Get full text

Age-dependent decrease in Toll-like receptor 4-mediated proinflammatory cytokine production and mitogen-activated protein kinase expression by Boehmer, Eric D., Goral, Joanna, Faunce, Douglas E., Kovacs, Elizabeth J.

“…Age‐related changes in immunity render elderly individuals more susceptible to infections than the young. Previous work by our laboratory and others showed…”
Get full text

Exhaled Nitric Oxide Levels Among Adults With Excessive Alcohol Consumption by Afshar, Majid, MD, MSCR, Poole, Jill A., MD, Cao, Guichan, MS, Durazo, Ramon, PhD, Cooper, Richard C., MD, Kovacs, Elizabeth J., PhD, Sisson, Joseph H., MD

“…Background More than one-quarter of the US population qualify as excessive alcohol consumers. Alcohol use impacts several lung diseases, and heavy consumption…”
Get full text

Organ-specific inflammation following acute ethanol and burn injury by Bird, Melanie D., Kovacs, Elizabeth J.

“…Clinical and experimental evidence demonstrates that ethanol exposure prior to injury alters local and systemic inflammatory responses, increasing morbidity…”
Get full text

Correction to: A novel murine model of multi-day moderate ethanol exposure reveals increased intestinal dysfunction and liver inflammation with age by McMahan, Rachel H, Najarro, Kevin M, Mullen, Juliet E, Paul, Madison T, Orlicky, David J, Hulsebus, Holly J, Kovacs, Elizabeth J

Get full text

Aspiration, Localized Pulmonary Inflammation, and Predictors of Early-Onset Bronchiolitis Obliterans Syndrome after Lung Transplantation by Fisichella, P. Marco, MD, FACS, Davis, Christopher S., MD, MPH, Lowery, Erin, MD, MS, Ramirez, Luis, BS, Gamelli, Richard L., MD, FACS, Kovacs, Elizabeth J., PhD

“…Background We hypothesized that immune mediator concentrations in the bronchoalveolar fluid (BALF) are predictive of bronchiolitis obliterans syndrome (BOS)…”
Get full text

Transcriptomics, metabolomics, and in-silico drug predictions for liver damage in young and aged burn victims by Malachowska, Beata, Yang, Weng-Lang, Qualman, Andrea, Muro, Israel, Boe, Devin M., Lampe, Jed N., Kovacs, Elizabeth J., Idrovo, Juan-Pablo

“…Burn induces a systemic response affecting multiple organs, including the liver. Since the liver plays a critical role in metabolic, inflammatory, and immune…”
Get full text

Aging negatively skews macrophage TLR2- and TLR4-mediated pro-inflammatory responses without affecting the IL-2-stimulated pathway by Boehmer, Eric D., Meehan, Michael J., Cutro, Brent T., Kovacs, Elizabeth J.

“…We recently reported that macrophages from aged mice produced less tumor necrosis factor (TNF)-α following lipopolysaccharide (LPS) stimulation than…”
Get full text

The protective role of laparoscopic antireflux surgery against aspiration of pepsin after lung transplantation by Fisichella, P. Marco, MD, FACS, Davis, Christopher S., MD, MPH, Lundberg, Peter W., MD, Lowery, Erin, MD, MS, Burnham, Ellen L., MD, MS, Alex, Charles G., MD, Ramirez, Luis, BS, Pelletiere, Karen, RN, BSN, Love, Robert B., MD, FACS, FRCS, Kuo, Paul C., MD, MS, MBA, Kovacs, Elizabeth J., PhD

“…Background The goal of this study was to determine, in lung transplant patients, if laparoscopic antireflux surgery (LARS) is an effective means to prevent…”
Get full text