Search Results - "Kovacic, Filip"

Predicting drug targets by homology modelling of Pseudomonas aeruginosa proteins of unknown function by Babic, Nikolina, Kovacic, Filip

“…The efficacy of antibiotics to treat bacterial infections declines rapidly due to antibiotic resistance. This problem has stimulated the development of novel…”
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The bacterial quorum sensing signal 2'-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection by Chakraborty, Arijit, Bandyopadhaya, Arunava, Singh, Vijay K, Kovacic, Filip, Cha, Sujin, Oldham, William M, Tzika, A Aria, Rahme, Laurence G

“…How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that ( ) a…”
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Disruption of microbial community composition and identification of plant growth promoting microorganisms after exposure of soil to rapeseed-derived glucosinolates by Siebers, Meike, Rohr, Thomas, Ventura, Marina, Schütz, Vadim, Thies, Stephan, Kovacic, Filip, Jaeger, Karl-Erich, Berg, Martin, Dörmann, Peter, Schulz, Margot

“…Land plants are engaged in intricate communities with soil bacteria and fungi indispensable for plant survival and growth. The plant-microbial interactions are…”
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Structural and dynamic insights revealing how lipase binding domain MD1 of Pseudomonas aeruginosa foldase affects lipase activation by Viegas, Aldino, Dollinger, Peter, Verma, Neha, Kubiak, Jakub, Viennet, Thibault, Seidel, Claus A. M., Gohlke, Holger, Etzkorn, Manuel, Kovacic, Filip, Jaeger, Karl-Erich

“…Folding and cellular localization of many proteins of Gram-negative bacteria rely on a network of chaperones and secretion systems. Among them is the…”
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Structural, mechanistic, and physiological insights into phospholipase A-mediated membrane phospholipid degradation in Pseudomonas aeruginosa by Bleffert, Florian, Granzin, Joachim, Caliskan, Muttalip, Schott-Verdugo, Stephan N, Siebers, Meike, Thiele, Björn, Rahme, Laurence, Felgner, Sebastian, Dörmann, Peter, Gohlke, Holger, Batra-Safferling, Renu, Jaeger, Karl-Erich, Kovacic, Filip

“…Cells steadily adapt their membrane glycerophospholipid (GPL) composition to changing environmental and developmental conditions. While the regulation of…”
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Heterologous production of the lipopeptide biosurfactant serrawettin W1 in Escherichia coli by Thies, Stephan, Santiago-Schübel, Beatrix, Kovačić, Filip, Rosenau, Frank, Hausmann, Rudolf, Jaeger, Karl-Erich

“…•The non-ionic lipopeptide serrawettin W1 is a biosurfactant produced by Serratia marcescens.•Serrawettin shows antimicrobial, antitumor and plant protecting…”
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A promiscuous ancestral enzyme´s structure unveils protein variable regions of the highly diverse metallo-β-lactamase family by Perez-Garcia, Pablo, Kobus, Stefanie, Gertzen, Christoph G. W., Hoeppner, Astrid, Holzscheck, Nicholas, Strunk, Christoph Heinrich, Huber, Harald, Jaeger, Karl-Erich, Gohlke, Holger, Kovacic, Filip, Smits, Sander H. J., Streit, Wolfgang R., Chow, Jennifer

“…The metallo-β-lactamase fold is an ancient protein structure present in numerous enzyme families responsible for diverse biological processes. The crystal…”
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Molecular Mechanisms Underlying Medium-Chain Free Fatty Acid-Regulated Activity of the Phospholipase PlaF from Pseudomonas aeruginosa by Gentile, Rocco, Modric, Matea, Thiele, Björn, Jaeger, Karl-Erich, Kovacic, Filip, Schott-Verdugo, Stephan, Gohlke, Holger

“…PlaF is a membrane-bound phospholipase A1 from Pseudomonas aeruginosa that is involved in remodeling membrane glycerophospholipids (GPLs) and modulating…”
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The metagenome-derived enzymes LipS and LipT increase the diversity of known lipases by Chow, Jennifer, Kovacic, Filip, Dall Antonia, Yuliya, Krauss, Ulrich, Fersini, Francesco, Schmeisser, Christel, Lauinger, Benjamin, Bongen, Patrick, Pietruszka, Joerg, Schmidt, Marlen, Menyes, Ina, Bornscheuer, Uwe T, Eckstein, Marrit, Thum, Oliver, Liese, Andreas, Mueller-Dieckmann, Jochen, Jaeger, Karl-Erich, Streit, Wolfgang R

“…Triacylglycerol lipases (EC 3.1.1.3) catalyze both hydrolysis and synthesis reactions with a broad spectrum of substrates rendering them especially suitable…”
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Cyclic Isothiocyanate Goitrin Impairs Lotus japonicus Nodulation, Affects the Proteomes of Nodules and Free Mesorhizobium loti , and Induces the Formation of Caffeic Acid Derivatives in Bacterial Cultures by Jeong, Seungwoo, Schütz, Vadim, Demir, Fatih, Preusche, Matthias, Huesgen, Pitter, Bigler, Laurent, Kovacic, Filip, Gutbrod, Katharina, Dörmann, Peter, Schulz, Margot

“…The continuous release of glucosinolates into the soil by Brassicaceae root exudation is a prerequisite to maintaining toxic levels of breakdown products such…”
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Identification of amino acids involved in the hydrolytic activity of lipase LipBL from Marinobacter lipolyticus by PEREZ, Dolores, KOVACIC, Filip, WILHELM, Susanne, JAEGER, Karl-Erich, GARCIA, María Teresa, VENTOSA, Antonio, MELLADO, Encarnación

“…The lipolytic enzyme family VIII currently includes only seven members but represents a group of lipolytic enzymes with interesting properties. Recently, we…”
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The periplasmic chaperone Skp prevents misfolding of the secretory lipase A from Pseudomonas aeruginosa by Papadopoulos, Athanasios, Busch, Max, Reiners, Jens, Hachani, Eymen, Baeumers, Miriam, Berger, Julia, Schmitt, Lutz, Jaeger, Karl-Erich, Kovacic, Filip, Smits, Sander H. J., Kedrov, Alexej

“…Pseudomonas aeruginosa is a wide-spread opportunistic human pathogen and a high-risk factor for immunodeficient people and patients with cystic fibrosis. The…”
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Probing Enzyme Promiscuity of SGNH Hydrolases by Leščić Ašler, Ivana, Ivić, Nives, Kovačić, Filip, Schell, Sabrina, Knorr, Janina, Krauss, Ulrich, Wilhelm, Susanne, Kojić-Prodić, Biserka, Jaeger, Karl-Erich

“…Several hydrolases of the SGNH superfamily, including the lipase SrLip from Streptomyces rimosus (Q93MW7), the acyl-CoA thioesterase I TesA from Pseudomonas…”
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Implications of Below-Ground Allelopathic Interactions of Camelina sativa and Microorganisms for Phosphate Availability and Habitat Maintenance by Hofmann, Diana, Thiele, Björn, Siebers, Meike, Rahmati, Mehdi, Schütz, Vadim, Jeong, Seungwoo, Cui, Jiaxin, Bigler, Laurent, Held, Federico, Wu, Bei, Babic, Nikolina, Kovacic, Filip, Hamacher, Joachim, Hölzl, Georg, Dörmann, Peter, Schulz, Margot

“…Toxic breakdown products of young (L.) Crantz, glucosinolates can eliminate microorganisms in the soil. Since microorganisms are essential for phosphate…”
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Bestimmung der Stabilität und Enantioselektivität von Lipasen by Fulton, Alexander, Kovacic, Filip, Schwaneberg, Ulrich, Pietruszka, Jörg, Jaeger, Karl-Erich

“…Enzymes play an increasingly important role for biotechnological applications. Hence, it is important to identify, isolate and characterize novel enzymes…”
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Inhibition of extracellular lipase from Streptomyces rimosus with 3,4-dichloroisocoumarin by Ašler, Ivana Leščić, Kovačić, Filip, Marchetti-Deschmann, Martina, Allmaier, Günter, Stefanić, Zoran, Kojić-Prodić, Biserka

“…Kinetic characterization of lipase inhibition was performed by activity measurement and mass spectrometry (MS), for the first time with serine-protease…”
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Structural and functional characterisation of TesA - a novel lysophospholipase A from Pseudomonas aeruginosa by Kovačić, Filip, Granzin, Joachim, Wilhelm, Susanne, Kojić-Prodić, Biserka, Batra-Safferling, Renu, Jaeger, Karl-Erich

“…TesA from Pseudomonas aeruginosa belongs to the GDSL hydrolase family of serine esterases and lipases that possess a broad substrate- and regiospecificity. It…”
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Erratum zu „Bestimmung der Stabilität und Enantioselektivität von Lipasen by Fulton, Alexander, Kovacic, Filip, Schwaneberg, Ulrich, Pietruszka, Jörg, Jaeger, Karl-Erich

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Pseudomonas aeruginosa patatin-like protein PlpD is the archetype of a novel Type V secretion system by Salacha, Richard, Kovačić, Filip, Brochier-Armanet, Céline, Wilhelm, Susanne, Tommassen, Jan, Filloux, Alain, Voulhoux, Romé, Bleves, Sophie

“…We discovered a novel secreted protein by Pseudomonas aeruginosa, PlpD, as a member of the bacterial lipolytic enzyme family of patatin-like proteins (PLPs)…”
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Structural features determining thermal adaptation of esterases by Kovacic, Filip, Mandrysch, Agathe, Poojari, Chetan, Strodel, Birgit, Jaeger, Karl-Erich

“…Abstract The adaptation of microorganisms to extreme living temperatures requires the evolution of enzymes with a high catalytic efficiency under these…”
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