Search Results - "Kovach, John S"

Pharmacologic inhibition of protein phosphatase-2A achieves durable immune-mediated antitumor activity when combined with PD-1 blockade by Ho, Winson S., Wang, Herui, Maggio, Dominic, Kovach, John S., Zhang, Qi, Song, Qi, Marincola, Francesco M., Heiss, John D., Gilbert, Mark R., Lu, Rongze, Zhuang, Zhengping

“…Mounting evidence suggests that inhibition of protein phosphatase-2A (PP2A), a serine/threonine phosphatase, could enhance anticancer immunity. However, drugs…”
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Inhibition of serine/threonine phosphatase PP2A enhances cancer chemotherapy by blocking DNA damage induced defense mechanisms by Lu, Jie, Kovach, John S, Johnson, Francis, Chiang, Jeffrey, Hodes, Richard, Lonser, Russell, Zhuang, Zhengping

“…A variety of mechanisms maintain the integrity of the genome in the face of cell stress. Cancer cell response to chemotherapeutic and radiation-induced DNA…”
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Urinary Cadmium and Osteoporosis in U.S. Women ≥ 50 Years of Age: NHANES 1988-1994 and 1999-2004 by Gallagher, Carolyn M., Kovach, John S., Meliker, Jaymie R.

“…Background: Urinary cadmium (U-Cd) has been associated with decreased peripheral bone mineral density (BMD) and osteoporosis. This association, however, has…”
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The relationship between body iron stores and blood and urine cadmium concentrations in US never-smoking, non-pregnant women aged 20–49 years by Gallagher, Carolyn M., Chen, John J., Kovach, John S.

“…Cadmium is a ubiquitous environmental pollutant associated with increased risk of leading causes of mortality and morbidity in women, including breast cancer…”
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Cadmium, follicle-stimulating hormone, and effects on bone in women age 42–60 years, NHANES III by Gallagher, Carolyn M., Moonga, Baljit S., Kovach, John S.

“…Increased body burden of environmental cadmium has been associated with greater risk of decreased bone mineral density (BMD) and osteoporosis in middle-aged…”
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Detection of Cancer-Specific Markers Amid Massive Mass Spectral Data by Zhu, Wei, Wang, Xuena, Ma, Yeming, Rao, Manlong, Glimm, James, Kovach, John S.

“…We propose a comprehensive pattern recognition procedure that will achieve best discrimination between two or more sets of subjects with data in the same…”
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Enhancement of cancer chemotherapy by simultaneously altering cell cycle progression and DNA-damage defenses through global modification of the serine/threonine phospho-proteome by Zhuang, Zhengping, Lu, Jie, Lonser, Russell R., Kovach, John S.

“…Despite improvements in the therapeutic efficacy of rationally designed cancer treatment regimens, most cancers remain incurable once spread beyond their sites…”
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Safety, Tolerability, and Preliminary Activity of LB-100, an Inhibitor of Protein Phosphatase 2A, in Patients with Relapsed Solid Tumors: An Open-Label, Dose Escalation, First-in-Human, Phase I Trial by Chung, Vincent, Mansfield, Aaron S, Braiteh, Fadi, Richards, Donald, Durivage, Henry, Ungerleider, Richard S, Johnson, Francis, Kovach, John S

“…To determine the MTD and to assess the safety, tolerability, and potential activity of LB-100, a first-in-class small-molecule inhibitor of protein phosphatase…”
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Environmental cadmium and breast cancer risk by Gallagher, Carolyn M, Chen, John J, Kovach, John S

“…Breast cancer is the most prevalent women's cancer, with an age-adjusted incidence of 122.9 per 100,000 US women. Cadmium, a ubiquitous carcinogenic pollutant…”
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An LC–MS/MS method for simultaneous determination of LB-100 and its active metabolite, endothall, in human plasma by Feng, Ye, Massarelli, Erminia, Forman, Eric, Kovach, John S, Salgia, Ravi, Synold, Timothy W

“…We have developed and validated a novel LC–MS/MS method for the simultaneous quantification of LB-100 and its active metabolite, endothall, in human plasma…”
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Inhibition of protein phosphatase-2A with LB-100 enhances antitumor immunity against glioblastoma by Maggio, Dominic, Ho, Winson S., Breese, Rebecca, Walbridge, Stuart, Wang, Herui, Cui, Jing, Heiss, John D., Gilbert, Mark R., Kovach, John S., Lu, Rongze O., Zhuang, Zhengping

“…Purpose Glioblastoma (GBM) carries a dismal prognosis despite standard multimodal treatment with surgery, chemotherapy and radiation. Immune checkpoint…”
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Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer by Mirzapoiazova, Tamara, Xiao, Gang, Mambetsariev, Bolot, Nasser, Mohd W, Miaou, Emily, Singhal, Sharad S, Srivastava, Saumya, Mambetsariev, Isa, Nelson, Michael S, Nam, Arin, Behal, Amita, Arvanitis, Leonidas, Atri, Pranita, Muschen, Markus, Tissot, François L H, Miser, James, Kovach, John S, Sattler, Martin, Batra, Surinder K, Kulkarni, Prakash, Salgia, Ravi

“…Protein phosphatase 2A (PP2A), a serine/threonine phosphatase involved in the regulation of apoptosis, proliferation, and DNA-damage response, is overexpressed…”
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Paradoxical Activation of Oncogenic Signaling as a Cancer Treatment Strategy by Dias, Matheus Henrique, Friskes, Anoek, Wang, Siying, Fernandes Neto, Joao M, van Gemert, Frank, Mourragui, Soufiane, Papagianni, Chrysa, Kuiken, Hendrik J, Mainardi, Sara, Alvarez-Villanueva, Daniel, Lieftink, Cor, Morris, Ben, Dekker, Anna, van Dijk, Emma, Wilms, Lieke H S, da Silva, Marcelo S, Jansen, Robin A, Mulero-Sánchez, Antonio, Malzer, Elke, Vidal, August, Santos, Cristina, Salazar, Ramón, Wailemann, Rosangela A M, Torres, Thompson E P, De Conti, Giulia, Raaijmakers, Jonne A, Snaebjornsson, Petur, Yuan, Shengxian, Qin, Wenxin, Kovach, John S, Armelin, Hugo A, Te Riele, Hein, van Oudenaarden, Alexander, Jin, Haojie, Beijersbergen, Roderick L, Villanueva, Alberto, Medema, Rene H, Bernards, Rene

“…Cancer homeostasis depends on a balance between activated oncogenic pathways driving tumorigenesis and engagement of stress response programs that counteract…”
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Correction: Protein Phosphatase 2A as a Therapeutic Target in Small Cell Lung Cancer by Mirzapoiazova, Tamara, Xiao, Gang, Mambetsariev, Bolot, Nasser, Mohd W, Miaou, Emily, Singhal, Sharad S, Srivastava, Saumya, Mambetsariev, Isa, Nelson, Michael S, Nam, Arin, Behal, Amita, Arvanitis, Leonidas D, Atri, Pranita, Muschen, Markus, Tissot, François L H, Miser, James, Kovach, John S, Sattler, Martin, Batra, Surinder K, Kulkarni, Prakash, Salgia, Ravi

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Inhibition of PP2A with LB-100 Enhances Efficacy of CAR-T Cell Therapy Against Glioblastoma by Cui, Jing, Wang, Herui, Medina, Rogelio, Zhang, Qi, Xu, Chen, Indig, Iris H, Zhou, Jingcheng, Song, Qi, Dmitriev, Pauline, Sun, Mitchell Y, Guo, Liemei, Wang, Yang, Rosenblum, Jared S, Kovach, John S, Gilbert, Mark R, Zhuang, Zhengping

“…Chimeric antigen receptor (CAR)-engineered T cells represent a promising modality for treating glioblastoma. Recently, we demonstrated that CAR-T cells…”
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Environmental cadmium and breast cancer risk by Gallagher, Carolyn M., Chen, John J., Kovach, John S.

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A Community and Academic Partnership to Improve Breast Cancer Outcomes for African Americans on Long Island: A Ministry of Health Dissemination by Schoenfeld, Elinor Randi, Davis, Margaret V., Kovach, John S., Mchunguzi, Cheryl, Nies, Mary A.

“…Communities on Long Island have a widespread interest and a pressing need for approaches to promote early detection and prompt treatment of breast cancer given…”
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A phase I study of a novel inhibitor of protein phosphatase 2A alone and with docetaxel by Mansfield, Aaron Scott, Chung, Vincent M., Kovach, John S.

“…Abstract only…”
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Abstract LB-193: Protein phosphatase 2A inhibition,with a novel small molecule inhibitor, LB-100, achieves durable immune-mediated antitumor activity when combined with PD1 blockade in a preclinical model by Ho, Winson S., Wang, Herui, Kovach, John S., Lu, Rongze, Zhuang, Zhengping

“…Abstract LB-100 is a novel, first-in-class, small molecule inhibitor of protein phosphatase 2A (PP2A) recently shown in a Phase I trial to be well-tolerated at…”
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Abstract A175: A phase 1 study of a novel inhibitor of protein phosphatase 2A alone or in combination with docetaxel by Chung, Vincent, Richards, Donald, Braiteh, Fadi, Kovach, John S., Mansfield, Aaron Scott

“…Abstract Background Protein phosphatase (PP2A) is a multifunctional protein involved in regulation of cell cycle, DNA-damage response, and apoptosis. LB-100, a…”
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