Search Results - "Kovac, Stjepana"

Seizures induced by direct electrical cortical stimulation – Mechanisms and clinical considerations by Kovac, Stjepana, Kahane, Philippe, Diehl, Beate

“…Highlights • CS-induced seizures are used to define the epileptogenic zone in some centres. • Other centres consider them as a by-product of CS with limited…”
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KEAP1 inhibition is neuroprotective and suppresses the development of epilepsy by Shekh-Ahmad, Tawfeeq, Eckel, Ramona, Dayalan Naidu, Sharadha, Higgins, Maureen, Yamamoto, Masayuki, Dinkova-Kostova, Albena T, Kovac, Stjepana, Abramov, Andrey Y, Walker, Matthew C

“…Reactive oxygen species are hypothesised to play a critical role in the development of epilepsy. Shekh-Ahmad et al. report that decreasing reactive oxygen…”
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Uncensored EEG: The role of DC potentials in neurobiology of the brain by Kovac, Stjepana, Speckmann, Erwin-Josef, Gorji, Ali

“…Brain direct current (DC) potentials denote sustained shifts and slow deflections of cerebral potentials superimposed with conventional electroencephalography…”
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Metabolic and Homeostatic Changes in Seizures and Acquired Epilepsy-Mitochondria, Calcium Dynamics and Reactive Oxygen Species by Kovac, Stjepana, Dinkova Kostova, Albena T, Herrmann, Alexander M, Melzer, Nico, Meuth, Sven G, Gorji, Ali

“…Acquired epilepsies can arise as a consequence of brain injury and result in unprovoked seizures that emerge after a latent period of epileptogenesis. These…”
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Astrocyte-mediated inflammation in cortical spreading depression by Ghaemi, Amir, Alizadeh, Leila, Babaei, Shahnaz, Jafarian, Maryam, Khaleghi Ghadiri, Maryam, Meuth, Sven G, Kovac, Stjepana, Gorji, Ali

“…Background Cortical spreading depression (CSD) related diseases such as migraine, cerebrovascular diseases, and epilepsy have been associated with reactive…”
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Carvacrol after status epilepticus (SE) prevents recurrent SE, early seizures, cell death, and cognitive decline by Khalil, Aytakin, Kovac, Stjepana, Morris, Gareth, Walker, Matthew C.

“…Summary Objective Carvacrol is a naturally occurring monoterpenic phenol that has been suggested to have an action at transient receptor potential cation…”
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Occurrence of status epilepticus in persons with epilepsy is determined by sex, epilepsy classification, and etiology: a single center cohort study by Langenbruch, Lisa, Strippel, Christine, Görlich, Dennis, Elger, Christian E., Möddel, Gabriel, Meuth, Sven G., Kellinghaus, Christoph, Wiendl, Heinz, Kovac, Stjepana

“…Background Status epilepticus (SE) can occur in persons with or without epilepsy and is associated with high morbidity and mortality. Methods This survey aimed…”
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Combination antioxidant therapy prevents epileptogenesis and modifies chronic epilepsy by Shekh-Ahmad, Tawfeeq, Lieb, Andreas, Kovac, Stjepana, Gola, Lukas, Christian Wigley, W, Abramov, Andrey Y, Walker, Matthew C

“…Many epilepsies are acquired conditions following an insult to the brain such as a prolonged seizure, traumatic brain injury or stroke. The generation of…”
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Prolonged seizure activity impairs mitochondrial bioenergetics and induces cell death by Kovac, Stjepana, Domijan, Ana-Marija, Walker, Matthew C, Abramov, Andrey Y

“…The mechanisms underlying neuronal death following excessive activity such as occurs during prolonged seizures are unclear, but mitochondrial dysfunction has…”
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K2P18.1 translates T cell receptor signals into thymic regulatory T cell development by Ruck, Tobias, Bock, Stefanie, Pfeuffer, Steffen, Schroeter, Christina B., Cengiz, Derya, Marciniak, Paul, Lindner, Maren, Herrmann, Alexander, Liebmann, Marie, Kovac, Stjepana, Gola, Lukas, Rolfes, Leoni, Pawlitzki, Marc, Opel, Nils, Hahn, Tim, Dannlowski, Udo, Pap, Thomas, Luessi, Felix, Schreiber, Julian A., Wünsch, Bernhard, Kuhlmann, Tanja, Seebohm, Guiscard, Tackenberg, Björn, Seja, Patricia, Döring, Frank, Wischmeyer, Erhard, Chasan, Achmet Imam, Roth, Johannes, Klotz, Luisa, Meyer zu Hörste, Gerd, Wiendl, Heinz, Marschall, Tobias, Floess, Stefan, Huehn, Jochen, Budde, Thomas, Bopp, Tobias, Bittner, Stefan, Meuth, Sven G.

“…It remains largely unclear how thymocytes translate relative differences in T cell receptor (TCR) signal strength into distinct developmental programs that…”
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Contactin-associated protein 2 autoantibodies can be associated with multifocal motor-like neuropathy: a case report by Müller-Miny, Louisa, Sauer, Raoul, Schulte-Mecklenbeck, Andreas, Gross, Catharina C., Kovac, Stjepana, Schilling, Matthias, Beuker, Carolin, Wiendl, Heinz, Meyer zu Hörste, Gerd

“…Autoantibodies against contactin-associated protein 2 (CASPR2) are usually associated with autoimmune encephalitis and neuromyotonia. Their association with…”
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Targeted and optimized multi-channel transcranial direct current stimulation for focal epilepsy: An N-of-1 trial by Antonakakis, Marios, Kaiser, Fabian, Rampp, Stefan, Kovac, Stjepana, Wiendl, Heinz, Stummer, Walter, Gross, Joachim, Kellinghaus, Christoph, Khaleghi-Ghadiri, Maryam, Möddel, Gabriel, Wolters, Carsten H.

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Cell injury and receptor expression in the epileptic human amygdala by Jafarian, Maryam, Modarres Mousavi, Sayed Mostafa, Alipour, Fatemeh, Aligholi, Hadi, Noorbakhsh, Farshid, Ghadipasha, Masoud, Gharehdaghi, Jaber, Kellinghaus, Christoph, Kovac, Stjepana, Khaleghi Ghadiri, Maryam, Meuth, Sven G., Speckmann, Erwin-Josef, Stummer, Walter, Gorji, Ali

“…Neuropathological findings in the amygdala obtained from patients with mesial temporal lobe epilepsy (MTLE) indicate varying degrees of histopathological…”
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Atonic phenomena in focal seizures: Nomenclature, clinical findings and pathophysiological concepts by Kovac, Stjepana, Diehl, Beate

“…Abstract Atonic seizures have traditionally been described in patients with generalized epilepsies; however, ictal atonia is increasingly recognized as a…”
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Flow cytometry identifies changes in peripheral and intrathecal lymphocyte patterns in CNS autoimmune disorders and primary CNS malignancies by Räuber, Saskia, Schulte-Mecklenbeck, Andreas, Willison, Alice, Hagler, Ramona, Jonas, Marius, Pul, Duygu, Masanneck, Lars, Schroeter, Christina B, Golombeck, Kristin S, Lichtenberg, Stefanie, Strippel, Christine, Gallus, Marco, Dik, Andre, Kerkhoff, Ruth, Barman, Sumanta, Weber, Katharina J, Kovac, Stjepana, Korsen, Melanie, Pawlitzki, Marc, Goebels, Norbert, Ruck, Tobias, Gross, Catharina C, Paulus, Werner, Reifenberger, Guido, Hanke, Michael, Grauer, Oliver, Rapp, Marion, Sabel, Michael, Wiendl, Heinz, Meuth, Sven G, Melzer, Nico

“…Abstract Background Immune dysregulation is a hallmark of autoimmune diseases of the central nervous system (CNS), characterized by an excessive immune…”
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Spreading depression triggers ictaform activity in partially disinhibited neuronal tissues by Eickhoff, Marius, Kovac, Stjepana, Shahabi, Parviz, Khaleghi Ghadiri, Maryam, Dreier, Jens P., Stummer, Walter, Speckmann, Erwin-Josef, Pape, Hans-Christian, Gorji, Ali

“…There is unequivocal electrophysiological evidence that spreading depression (SD) can trigger epileptiform field potentials. In vitro experiments on human…”
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NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody by Malviya, Manish, Barman, Sumanta, Golombeck, Kristin S., Planagumà, Jesús, Mannara, Francesco, Strutz‐Seebohm, Nathalie, Wrzos, Claudia, Demir, Fatih, Baksmeier, Christine, Steckel, Julia, Falk, Kim Kristin, Gross, Catharina C., Kovac, Stjepana, Bönte, Kathrin, Johnen, Andreas, Wandinger, Klaus‐Peter, Martín‐García, Elena, Becker, Albert J., Elger, Christian E., Klöcker, Nikolaj, Wiendl, Heinz, Meuth, Sven G., Hartung, Hans‐Peter, Seebohm, Guiscard, Leypoldt, Frank, Maldonado, Rafael, Stadelmann, Christine, Dalmau, Josep, Melzer, Nico, Goebels, Norbert

“…Objective Autoimmune encephalitis is most frequently associated with anti‐NMDAR autoantibodies. Their pathogenic relevance has been suggested by passive…”
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MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD by Korn, Lisanne, Speicher, Anna M., Schroeter, Christina B., Gola, Lukas, Kaehne, Thilo, Engler, Alexander, Disse, Paul, Fernández-Orth, Juncal, Csatári, Júlia, Naumann, Michael, Seebohm, Guiscard, Meuth, Sven G., Schöler, Hans R., Wiendl, Heinz, Kovac, Stjepana, Pawlowski, Matthias

“…Tauopathies are a major type of proteinopathies underlying neurodegenerative diseases. Mutations in the tau-encoding MAPT-gene lead to hereditary cases of…”
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Tackling obstacles for gene therapy targeting neurons: disrupting perineural nets with hyaluronidase improves transduction by Wanisch, Klaus, Kovac, Stjepana, Schorge, Stephanie

“…Gene therapy has been proposed for many diseases in the nervous system. In most cases for successful treatment, therapeutic vectors must be able to transduce…”
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Impact of COVID-19 pandemic on physical and mental health status and care of adults with epilepsy in Germany by Körbel, Kimberly, Rosenow, Felix, Maltseva, Margarita, Müller, Heiko, Schulz, Juliane, Tsalouchidou, Panagiota-Eleni, Langenbruch, Lisa, Kovac, Stjepana, Menzler, Katja, Hamacher, Mario, von Podewils, Felix, Willems, Laurent M, Mann, Catrin, Strzelczyk, Adam

“…Abstract Background To mitigate the potential consequences of the coronavirus disease 2019 (COVID-19) pandemic on public life, the German Federal Government…”
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