Search Results - "Kovačková, Soňa"

Lipophosphonoxins: New Modular Molecular Structures with Significant Antibacterial Properties by Rejman, Dominik, Rabatinová, Alžbeta, Pombinho, António R, Kovačková, Soňa, Pohl, Radek, Zbornı́ková, Eva, Kolář, Milan, Bogdanová, Kateřina, Nyč, Otakar, Šanderová, Hana, Látal, Tomáš, Bartůněk, Petr, Krásný, Libor

“…Novel compounds termed lipophosphonoxins were prepared using a simple and efficient synthetic approach. The general structure of lipophosphonoxins consists of…”
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The synthesis of piperidine nucleoside analogs—a comparison of several methods to access the introduction of nucleobases by Kovačková, Soňa, Dračínský, Martin, Rejman, Dominik

“…This work deals with the synthesis of piperidine and hydroxypiperidine analogs of nucleosides. Starting from commercially available 3-hydroxypiperidine,…”
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A convenient, high-yield synthesis of 1-substituted uracil and thymine derivatives by Rejman, Dominik, Kovačková, Soňa, Pohl, Radek, Dračínský, Martin, Fiedler, Pavel, Rosenberg, Ivan

“…Novel reagents for the synthesis of 1-substituted uracil and thymine derivatives have been developed. The aminolysis of 2- or 4-nitrophenyl…”
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Mechanism of the Isotopic Exchange Reaction of the 5-H Hydrogen of Uracil Derivatives in Water and Nonprotic Solvents by Dračínský, Martin, Jansa, Petr, Chocholoušová, Jana, Vacek, Jaroslav, Kovačková, Soňa, Holý, Antonín

“…The mechanism of the isotopic exchange reaction of the 5‐H hydrogen of uracil and its methyl derivatives in water and organic solvents has been studied. The…”
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Piperidine nucleosides and nucleotides by Kovačková, Soňa, Pačes, Ondřej, Dračínský, Martin, Rosenberg, Ivan, Rejman, Dominik

“…Abstract A novel series of racemic piperidin-3-yl and piperidin-4-yl derivatives of nucleobases and their phosphonate derivatives were prepared…”
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Pyrrolidine analogues of nucleosides and nucleotides by Rejman, Dominik, Pohl, Radek, Kovačková, Soňa, Kočalka, Petr, Švenková, Alžběta, Šanderová, Hana, Krásný, Libor, Rosenberg, Ivan

“…Abstract Among the structurally diverse nucleoside phosphonic acids, several compounds possessing strong antiviral properties have been found. Our effort in…”
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Selective Inhibitors of Cyclin G Associated Kinase (GAK) as Anti-Hepatitis C Agents by Kovackova, Sona, Chang, Lei, Bekerman, Elena, Neveu, Gregory, Barouch-Bentov, Rina, Chaikuad, Apirat, Heroven, Christina, Šála, Michal, De Jonghe, Steven, Knapp, Stefan, Einav, Shirit, Herdewijn, Piet

“…Cyclin G associated kinase (GAK) emerged as a promising drug target for the treatment of viral infections. However, no potent and selective GAK inhibitors have…”
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Isotopic Exchange of Hydrogen at C‐5 in Pyrimidine Derivatives: Tautomers with an sp 3 ‐Hybridised C‐5 Carbon Atom by Dračínský, Martin, Holý, Antonín, Jansa, Petr, Kovačková, Soňa, Buděšínský, Miloš

“…Abstract The proton‐to‐deuterium exchange reaction of the hydrogen atom at the 5‐position of 15 pyrimidine derivatives has been studied. The exchange proceeds…”
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Fluorescent 6-hydroxy- and 6,7-dihydroxy-4-trifluoro-methylcarbostyrils and formation of o-carboxymethylated derivatives via o-succinimide esters by Uray, Georg, Badgujar, Naresh S., Kováčková, Sona, Stadlbauer, Wolfgang

“…Stepwise demethylation of fluorescent 6,7‐dimethoxy‐3‐trifluoromethylcarbostyrils 5 leads to 6‐hydroxy derivatives 6 and 6,7‐dihydroxyderivative 7. Phenolate…”
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Synthesis of coumarin–nucleoside conjugates via Huisgen 1,3-dipolar cycloaddition by Kosiova, Ivana, Kovackova, Sona, Kois, Pavol

“…An efficient synthesis of fluorescent coumarin–nucleoside conjugates via Cu(I) catalysed Huisgen 1,3-dipolar cycloaddition is described. Starting from…”
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Discovery of Dual Death-Associated Protein Related Apoptosis Inducing Protein Kinase 1 and 2 Inhibitors by a Scaffold Hopping Approach by Gao, Ling-Jie, Kovackova, Sona, Šála, Michal, Ramadori, Anna Teresa, De Jonghe, Steven, Herdewijn, Piet

“…DRAK2 emerged as a promising drug target for the treatment of autoimmune diseases and to prevent graft rejection after organ transplantation. Screening of a…”
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Nucleoside Phosphonic Acids in Thymidine Phosphorylase Inhibition: Structure - Activity Relationship by Panova, Natalya, Košiová, Ivana, Petrová, Magdalena, Vaněk, Václav, Liboska, Radek, Kovačková, Soňa, Kočalka, Petr, Králíková, Šárka, Točík, Zdeněk, Páv, Ondřej, Pačes, Ondřej, Rejman, Dominik, Rosenberg, Ivan

“…Abstract A number of structurally diverse nucleoside phosphonic acids have been tested against human recombinant thymidine phosphorylase and human platelets…”
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Selective inhibitors of Cyclin-G associated kinase (GAK) as anti-HCV agents by Kovackova, Sona, Chang, Lei, Bekerman, Elena, Neveu, Gregory, Barouch-Bentov, Rina, Chaikuad, Apirat, Heroven, Christina, Šála, Michal, De Jonghe, Steven, Knapp, Stefan, Einav, Shirit, Herdewijn, Piet

“…Cyclin-G associated kinase (GAK) emerged as a promising drug target for the treatment of viral infections. However, no potent and selective GAK inhibitors have…”
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Isotopic Exchange of Hydrogen at C‐5 in Pyrimidine Derivatives: Tautomers with an sp3‐Hybridised C‐5 Carbon Atom by Dračínský, Martin, Holý, Antonín, Jansa, Petr, Kovačková, Soňa, Buděšínský, Miloš

“…The proton‐to‐deuterium exchange reaction of the hydrogen atom at the 5‐position of 15 pyrimidine derivatives has been studied. The exchange proceeds under…”
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