Search Results - "Kouzel, Ian U."
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MAPP unravels frequent co-regulation of splicing and polyadenylation by RNA-binding proteins and their dysregulation in cancer
Published in Nature communications (15-05-2024)“…Maturation of eukaryotic pre-mRNAs via splicing and polyadenylation is modulated across cell types and conditions by a variety of RNA-binding proteins (RBPs)…”
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Histone demethylase Lsd1 is required for the differentiation of neural cells in Nematostella vectensis
Published in Nature communications (24-01-2022)“…Chromatin regulation is a key process in development but its contribution to the evolution of animals is largely unexplored. Chromatin is regulated by a…”
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NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis
Published in Nature communications (10-08-2023)“…Neurogenesis has been studied extensively in the ectoderm, from which most animals generate the majority of their neurons. Neurogenesis from non-ectodermal…”
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Pitstop‐2 and its novel derivative RVD‐127 disrupt global cell dynamics and nuclear pores integrity by direct interaction with small GTPases
Published in Bioengineering & translational medicine (01-07-2023)“…Clathrin‐mediated endocytosis (CME) is an essential cell physiological process of broad biomedical relevance. Since the recent introduction of Pitstop‐2 as a…”
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scTEA-db: a comprehensive database of novel terminal exon isoforms identified from human single cell transcriptomes
Published in Nucleic acids research (05-01-2024)“…The usage of alternative terminal exons results in messenger RNA (mRNA) isoforms that differ in their 3' untranslated regions (3' UTRs) and often also in their…”
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RpoS Acts as a Global Repressor of Virulence Gene Expression in Escherichia coli O104:H4 and Enteroaggregative E coli
Published in The Journal of infectious diseases (16-10-2024)“…In 2011, in Germany, Escherichia coli O104:H4 caused the enterohemorrhagic E coli (EHEC) outbreak with the highest incidence rate of hemolytic uremic syndrome…”
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