Localization of leptin receptor mRNA expression in mouse brain

The distribution of the leptin receptor in the brain of C57 mice was investigated using a non-radioactive in situ hybridization method. Leptin receptor mRNA expression was highest in the arcuate nucleus and median eminence of the hypothalamus, but it was also abundant in hippocampus, primarily in th...

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Bibliographic Details
Published in:	Neuroreport Vol. 7; no. 15-17; p. 2635
Main Authors:	Huang, X F, Koutcherov, I, Lin, S, Wang, H Q, Storlien, L
Format:	Journal Article
Language:	English
Published:	England 04-11-1996
Subjects:	Animals Base Sequence Brain - metabolism Carrier Proteins - metabolism Female In Situ Hybridization Male Mice Mice, Inbred C57BL Molecular Sequence Data Receptors, Cell Surface Receptors, Leptin
Online Access:	Get more information
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Summary:	The distribution of the leptin receptor in the brain of C57 mice was investigated using a non-radioactive in situ hybridization method. Leptin receptor mRNA expression was highest in the arcuate nucleus and median eminence of the hypothalamus, but it was also abundant in hippocampus, primarily in the dentate gyrus and CA1, and was detected at low levels in piriform cortex and the medial margin of the medial habenular nucleus. The localization of leptin receptor-containing neurones in the present study indicates the possibility that the leptin receptor is expressed on neuropeptide Y-containing neurones.
ISSN:	0959-4965
DOI:	10.1097/00001756-199611040-00045