Search Results - "Koushika, Sandhya P"

A synthetic icosahedral DNA-based host–cargo complex for functional in vivo imaging by Bhatia, Dhiraj, Surana, Sunaina, Chakraborty, Saikat, Koushika, Sandhya P., Krishnan, Yamuna

“…The encapsulation of molecular cargo within well-defined supramolecular architectures is highly challenging. Synthetic hosts are desirable because of their…”
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Neurodegeneration and microtubule dynamics: death by a thousand cuts by Dubey, Jyoti, Ratnakaran, Neena, Koushika, Sandhya P

“…Microtubules form important cytoskeletal structures that play a role in establishing and maintaining neuronal polarity, regulating neuronal morphology,…”
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Crowd Control: Effects of Physical Crowding on Cargo Movement in Healthy and Diseased Neurons by Sabharwal, Vidur, Koushika, Sandhya P.

“…High concentration of cytoskeletal filaments, organelles, and proteins along with the space constraints due to the axon’s narrow geometry lead inevitably to…”
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The C-terminal of CASY-1/Calsyntenin regulates GABAergic synaptic transmission at the Caenorhabditis elegans neuromuscular junction by Thapliyal, Shruti, Vasudevan, Amruta, Dong, Yongming, Bai, Jihong, Koushika, Sandhya P, Babu, Kavita

“…The C. elegans ortholog of mammalian calsyntenins, CASY-1, is an evolutionarily conserved type-I transmembrane protein that is highly enriched in the nervous…”
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UNC-33 (CRMP) and ankyrin organize microtubules and localize kinesin to polarize axon-dendrite sorting by Maniar, Tapan A, Kaplan, Miriam, Wang, George J, Shen, Kang, Wei, Li, Shaw, Jocelyn E, Koushika, Sandhya P, Bargmann, Cornelia I

“…Polarized transport to axons and dendrites is critical for neuronal function, but the molecular mechanisms and cytoskeletal cues for asymmetry are incompletely…”
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LRK-1/LRRK2 and AP-3 regulate trafficking of synaptic vesicle precursors through active zone protein SYD-2/Liprin-α by Nadiminti, Sravanthi S P, Dixit, Shirley B, Ratnakaran, Neena, Deb, Anushka, Hegde, Sneha, Boyanapalli, Sri Padma Priya, Swords, Sierra, Grant, Barth D, Koushika, Sandhya P

“…Synaptic vesicle proteins (SVps) are transported by the motor UNC-104/KIF1A. We show that SVps travel in heterogeneous carriers in C. elegans neuronal…”
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UNC-16 alters DLK-1 localization and negatively regulates actin and microtubule dynamics in Caenorhabditis elegans regenerating neurons by Kulkarni, Sucheta S, Sabharwal, Vidur, Sheoran, Seema, Basu, Atrayee, Matsumoto, Kunihiro, Hisamoto, Naoki, Ghosh-Roy, Anindya, Koushika, Sandhya P

“…Abstract Neuronal regeneration after injury depends on the intrinsic growth potential of neurons. Our study shows that UNC-16, a Caenorhabditis elegans JIP3…”
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Cargo crowding at actin‐rich regions along axons causes local traffic jams by Sood, Parul, Murthy, Kausalya, Kumar, Vinod, Nonet, Michael L., Menon, Gautam I., Koushika, Sandhya P.

“…Steady axonal cargo flow is central to the functioning of healthy neurons. However, a substantial fraction of cargo in axons remains stationary up to several…”
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Synaptic branch stability is mediated by non-enzymatic functions of MEC-17/αTAT1 and ATAT-2 by Teoh, Jean-Sébastien, Vasudevan, Amruta, Wang, Wenyue, Dhananjay, Samiksha, Chandhok, Gursimran, Pocock, Roger, Koushika, Sandhya P., Neumann, Brent

“…Microtubules are fundamental elements of neuronal structure and function. They are dynamic structures formed from protofilament chains of α- and β-tubulin…”
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The vesicle protein SAM-4 regulates the processivity of synaptic vesicle transport by Zheng, Qun, Ahlawat, Shikha, Schaefer, Anneliese, Mahoney, Tim, Koushika, Sandhya P, Nonet, Michael L

“…Axonal transport of synaptic vesicles (SVs) is a KIF1A/UNC-104 mediated process critical for synapse development and maintenance yet little is known of how SV…”
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UNC-16/JIP3 regulates early events in synaptic vesicle protein trafficking via LRK-1/LRRK2 and AP complexes by Choudhary, Bikash, Kamak, Madhushree, Ratnakaran, Neena, Kumar, Jitendra, Awasthi, Anjali, Li, Chun, Nguyen, Ken, Matsumoto, Kunihiro, Hisamoto, Naoki, Koushika, Sandhya P

“…JIP3/UNC-16/dSYD is a MAPK-scaffolding protein with roles in protein trafficking. We show that it is present on the Golgi and is necessary for the polarized…”
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"JIP"ing along the axon: the complex roles of JIPs in axonal transport by Koushika, Sandhya P.

“…JIPs are JNK interacting proteins and bind to JNK cascade kinases. JIP1 and JIP3 were known to be adaptors linking cargo to Kinesin‐I, a major molecular motor…”
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Imaging in vivo Neuronal Transport in Genetic Model Organisms Using Microfluidic Devices by Mondal, Sudip, Ahlawat, Shikha, Rau, Kaustubh, Venkataraman, V., Koushika, Sandhya P.

“…Microfluidic devices have been developed for imaging behavior and various cellular processes in Caenorhabditis elegans, but not subcellular processes requiring…”
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Tissue-specific targeting of DNA nanodevices in a multicellular living organism by Chakraborty, Kasturi, Anees, Palapuravan, Surana, Sunaina, Martin, Simona, Aburas, Jihad, Moutel, Sandrine, Perez, Franck, Koushika, Sandhya P, Kratsios, Paschalis, Krishnan, Yamuna

“…Nucleic acid nanodevices present great potential as agents for logic-based therapeutic intervention as well as in basic biology. Often, however, the disease…”
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RAB-6.1 and RAB-6.2 Promote Retrograde Transport in C. elegans by Zhang, Donglei, Dubey, Jyoti, Koushika, Sandhya P, Rongo, Christopher

“…Retrograde transport is a critical mechanism for recycling certain membrane cargo. Following endocytosis from the plasma membrane, retrograde cargo is moved…”
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The Caenorhabditis elegans Kinesin-3 motor UNC-104/KIF1A is degraded upon loss of specific binding to cargo by Kumar, Jitendra, Choudhary, Bikash C, Metpally, Raghu, Zheng, Qun, Nonet, Michael L, Ramanathan, Sowdhamini, Klopfenstein, Dieter R, Koushika, Sandhya P

“…UNC-104/KIF1A is a Kinesin-3 motor that transports synaptic vesicles from the cell body towards the synapse by binding to PI(4,5)P(2) through its PH domain…”
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Loss of the Putative RNA-Directed RNA Polymerase RRF-3 Makes C. elegans Hypersensitive to RNAi by Simmer, Femke, Tijsterman, Marcel, Parrish, Susan, Koushika, Sandhya P, Nonet, Michael L, Fire, Andrew, Ahringer, Julie, Plasterk, Ronald H.A

“…RNA interference (RNAi) is a broadly used reverse genetics method in C. elegans [1]. Unfortunately, RNAi does not inhibit all genes [2, 3]. We show that loss…”
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Distinct DNA binding sites contribute to the TCF transcriptional switch in C. elegans and Drosophila by Bhambhani, Chandan, Ravindranath, Aditi J, Mentink, Remco A, Chang, Mikyung V, Betist, Marco C, Yang, Yaxuan X, Koushika, Sandhya P, Korswagen, Hendrik C, Cadigan, Ken M

“…Regulation of gene expression by signaling pathways often occurs through a transcriptional switch, where the transcription factor responsible for…”
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Transport-dependent maturation of organelles in neurons by Mathew, Amal, Koushika, Sandhya P.

“…Some organelles show a spatial gradient of maturation along the neuronal process where more mature organelles are found closer to the cell body. This gradient…”
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A post-docking role for active zone protein Rim by Nonet, Michael L, Koushika, Sandhya P, Richmond, Janet E, Hadwiger, Gayla, Weimer, Robby M, Jorgensen, Erik M

“…Rim1 was previously identified as a Rab3 effector localized to the presynaptic active zone in vertebrates. Here we demonstrate that C. elegans unc-10 mutants…”
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