Search Results - "Kouril, Theresa"

N-Myc-induced metabolic rewiring creates novel therapeutic vulnerabilities in neuroblastoma by Tjaden, Britta, Baum, Katharina, Marquardt, Viktoria, Simon, Mareike, Trajkovic-Arsic, Marija, Kouril, Theresa, Siebers, Bettina, Lisec, Jan, Siveke, Jens T., Schulte, Johannes H., Benary, Uwe, Remke, Marc, Wolf, Jana, Schramm, Alexander

“…N-Myc is a transcription factor that is aberrantly expressed in many tumor types and is often correlated with poor patient prognosis. Recently, several lines…”
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The Carbon Switch at the Level of Pyruvate and Phosphoenolpyruvate in Sulfolobus solfataricus P2 by Haferkamp, Patrick, Tjaden, Britta, Shen, Lu, Bräsen, Christopher, Kouril, Theresa, Siebers, Bettina

“…P2 grows on different carbohydrates as well as alcohols, peptides and amino acids. Carbohydrates such as D-glucose or D-galactose are degraded via the…”
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Systems biology of the modified branched Entner-Doudoroff pathway in Sulfolobus solfataricus by Figueiredo, Ana Sofia, Kouril, Theresa, Esser, Dominik, Haferkamp, Patrick, Wieloch, Patricia, Schomburg, Dietmar, Ruoff, Peter, Siebers, Bettina, Schaber, Jörg

“…Sulfolobus solfataricus is a thermoacidophilic Archaeon that thrives in terrestrial hot springs (solfatares) with optimal growth at 80°C and pH 2-4. It…”
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novel trehalose synthesizing pathway in the hyperthermophilic Crenarchaeon Thermoproteus tenax: the unidirectional TreT pathway by Kouril, Theresa, Zaparty, Melanie, Marrero, Jeannette, Brinkmann, Henner, Siebers, Bettina

“…In the genome of the hyperthermophilic archaeon Thermoproteus tenax a gene (treS/P) encoding a protein with similarity to annotated trehalose phosphorylase…”
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Volatilisation of metals and metalloids: An inherent feature of methanoarchaea? by Meyer, Jörg, Michalke, Klaus, Kouril, Theresa, Hensel, Reinhard

“…As shown by recent studies, anaerobic members of Archaea and Bacteria are involved in processes that transform ionic species of metals and metalloids (arsenic,…”
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Kinetic modelling of glycolytic oscillations by van Niekerk, David D, van Wyk, Morne, Kouril, Theresa, Snoep, Jacky L

“…Glycolytic oscillations have been studied for well over 60 years, but aspects of their function, and mechanisms of regulation and synchronisation remain…”
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Inhibitor titrations reveal low control of glyceraldehyde 3-phosphate dehydrogenase and high control of hexokinase on glycolytic flux in an aggressive triple-negative breast cancer cell line by Kouril, Theresa, October, Craig, Hollocks, Stephanie, Odendaal, Christoff, van Niekerk, David D., Snoep, Jacky L.

“…The glycolytic flux, and in particular lactate production, is strongly increased in cancer cells compared to normal cells, a characteristic often referred to…”
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Phosphoglycerate kinase acts as a futile cycle at high temperature by Kouril, Theresa, Eicher, Johann J, Siebers, Bettina, Snoep, Jacky L

“…In (hyper)thermophilic organisms metabolic processes have to be adapted to function optimally at high temperature. We compared the gluconeogenic conversion of…”
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Enhanced underground metabolism challenges life at high temperature–metabolic thermoadaptation in hyperthermophilic Archaea by Schmerling, Christian, Kouril, Theresa, Snoep, Jacky, Bräsen, Christopher, Siebers, Bettina

“…The text-book picture of a perfect, well organised metabolism with highly specific enzymes, is challenged by non-enzymatic reactions and promiscuous enzymes…”
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A systems biology approach reveals major metabolic changes in the thermoacidophilic archaeon Sulfolobus solfataricus in response to the carbon source L‐fucose versus D‐glucose by Wolf, Jacqueline, Stark, Helge, Fafenrot, Katharina, Albersmeier, Andreas, Pham, Trong K., Müller, Katrin B., Meyer, Benjamin H., Hoffmann, Lena, Shen, Lu, Albaum, Stefan P., Kouril, Theresa, Schmidt‐Hohagen, Kerstin, Neumann‐Schaal, Meina, Bräsen, Christopher, Kalinowski, Jörn, Wright, Phillip C., Albers, Sonja‐Verena, Schomburg, Dietmar, Siebers, Bettina

“…Summary Archaea are characterised by a complex metabolism with many unique enzymes that differ from their bacterial and eukaryotic counterparts. The…”
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Intermediate instability at high temperature leads to low pathway efficiency for an in vitro reconstituted system of gluconeogenesis in Sulfolobus solfataricus by Kouril, Theresa, Esser, Dominik, Kort, Julia, Westerhoff, Hans V., Siebers, Bettina, Snoep, Jacky L.

“…Four enzymes of the gluconeogenic pathway in Sulfolobus solfataricus were purified and kinetically characterized. The enzymes were reconstituted in vitro to…”
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One-step synthesis of 2-keto-3-deoxy-d-gluconate by biocatalytic dehydration of d-gluconate by Matsubara, Kohei, Köhling, Rudi, Schönenberger, Bernhard, Kouril, Theresa, Esser, Dominik, Bräsen, Christopher, Siebers, Bettina, Wohlgemuth, Roland

“…•A novel highly economic production procedure for stereochemically pure 2-keto-3-deoxy-d-gluconate (d-KDG) from d-gluconate is presented.•d-KDG is produced…”
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The Peculiar Glycolytic Pathway in Hyperthermophylic Archaea: Understanding Its Whims by Experimentation In Silico by Zhang, Yanfei, Kouril, Theresa, Snoep, Jacky L, Siebers, Bettina, Barberis, Matteo, Westerhoff, Hans V

“…Mathematical models are key to systems biology where they typically describe the topology and dynamics of biological networks, listing biochemical entities and…”
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Unraveling the function of the two Entner–Doudoroff branches in the thermoacidophilic Crenarchaeon Sulfolobus solfataricus P2 by Kouril, Theresa, Wieloch, Patricia, Reimann, Julia, Wagner, Michaela, Zaparty, Melanie, Albers, Sonja‐Verena, Schomburg, Dietmar, Ruoff, Peter, Siebers, Bettina

“…Sulfolobus solfataricus P2 is a thermoacidophilic archaeon that metabolizes glucose and galactose via an unusual branched Entner–Doudoroff (ED) pathway, which…”
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A systems biology approach reveals major metabolic changes in the thermoacidophilic archaeon S ulfolobus solfataricus in response to the carbon source L ‐fucose versus D ‐glucose by Wolf, Jacqueline, Stark, Helge, Fafenrot, Katharina, Albersmeier, Andreas, Pham, Trong K., Müller, Katrin B., Meyer, Benjamin H., Hoffmann, Lena, Shen, Lu, Albaum, Stefan P., Kouril, Theresa, Schmidt‐Hohagen, Kerstin, Neumann‐Schaal, Meina, Bräsen, Christopher, Kalinowski, Jörn, Wright, Phillip C., Albers, Sonja‐Verena, Schomburg, Dietmar, Siebers, Bettina

“…Archaea are characterised by a complex metabolism with many unique enzymes that differ from their bacterial and eukaryotic counterparts. The thermoacidophilic…”
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“Hot standards” for the thermoacidophilic archaeon Sulfolobus solfataricus by Zaparty, Melanie, Esser, Dominik, Gertig, Susanne, Haferkamp, Patrick, Kouril, Theresa, Manica, Andrea, Pham, Trong K, Reimann, Julia, Schreiber, Kerstin, Sierocinski, Pawel, Teichmann, Daniela, van Wolferen, Marleen, von Jan, Mathias, Wieloch, Patricia, Albers, Sonja V, Driessen, Arnold J. M, Klenk, Hans-Peter, Schleper, Christa, Schomburg, Dietmar, van der Oost, John, Wright, Phillip C, Siebers, Bettina

“…Within the archaea, the thermoacidophilic crenarchaeote Sulfolobus solfataricus has become an important model organism for physiology and biochemistry,…”
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Functional curation of the Sulfolobus solfataricus P2 and S. acidocaldarius 98-3 complete genome sequences by Esser, Domink, Kouril, Theresa, Zaparty, Melanie, Sierocinski, Pawel, Chan, Patricia P., Lowe, Todd, Van der Oost, John, Albers, Sonja-Verena, Schomburg, Dietmar, Makarova, Kira S., Siebers, Bettina

“…The thermoacidophiles Sulfolobus solfataricus P2 and S. acidocaldarius 98-3 are considered key model organisms representing a major phylum of the…”
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A novel trehalose synthesizing pathway in the hyperthermophilic Crenarchaeon Thermoproteus tenax : the unidirectional TreT pathway: Genome function and gene regulation in Archaea by KOURIL, Theresa, ZAPARTY, Melanie, MARRERO, Jeannette, BRINKMANN, Henner, SIEBERS, Bettina

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SulfoSYS (Sulfolobus Systems Biology): towards a silicon cell model for the central carbohydrate metabolism of the archaeon Sulfolobus solfataricus under temperature variation by Albers, Sonja-Verena, Birkeland, Nils-Kåre, Driessen, Arnold J M, Gertig, Susanne, Haferkamp, Patrick, Klenk, Hans-Peter, Kouril, Theresa, Manica, Andrea, Pham, Trong K, Ruoff, Peter, Schleper, Christa, Schomburg, Dietmar, Sharkey, Kieran J, Siebers, Bettina, Sierocinski, Pawel, Steuer, Ralf, van der Oost, John, Westerhoff, Hans V, Wieloch, Patricia, Wright, Phillip C, Zaparty, Melanie

“…SulfoSYS (Sulfolobus Systems Biology) focuses on the study of the CCM (central carbohydrate metabolism) of Sulfolobus solfataricus and its regulation under…”
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