Immunohistochemical detection of HPV proteins and c-erbB receptors in cervical lesion specimens from young women

The intention of the present study was to assess immunohistochemically the expression of c-erbB receptor family in cervical carcinoma specimens of young women. Simultaneously, HPV was detected in the same specimens using immunohistochemical assays. Seventy-five cervical intraepithelial and invasive...

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Bibliographic Details
Published in:	European journal of gynaecological oncology Vol. 27; no. 1; p. 69
Main Authors:	Ravazoula, P, Androutsopoulos, G, Koumoundouroul, D, Michail, G, Kourounis, G
Format:	Journal Article
Language:	English
Published:	Italy 2006
Subjects:	Adult Age Factors Biopsy, Needle Cervical Intraepithelial Neoplasia - metabolism Cervical Intraepithelial Neoplasia - pathology Female Gene Expression Regulation, Neoplastic Humans Immunohistochemistry Neoplasm Invasiveness - pathology Papillomaviridae - isolation & purification Prognosis Receptor, ErbB-2 - metabolism Retrospective Studies Risk Assessment Sensitivity and Specificity Uterine Cervical Neoplasms - metabolism Uterine Cervical Neoplasms - pathology Viral Proteins - metabolism
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Summary:	The intention of the present study was to assess immunohistochemically the expression of c-erbB receptor family in cervical carcinoma specimens of young women. Simultaneously, HPV was detected in the same specimens using immunohistochemical assays. Seventy-five cervical intraepithelial and invasive cancer specimens were assessed retrospectively. Positive c-erbB-2 immunostaining was revealed in 11.7% of tumor specimens, while for c-erbB-3 and c-erbB-4 receptor the corresponding figures were 32% and 49.3%, respectively. Concerning HPV infection-markers, positive immunostaining was found in 31% of cases, while coilocytes were detected in 64% of patients. The correlation of c-erbB receptor expression with malignant aggressiveness in cervical cancer cells concurs with similar data regarding other neoplasias, thus rendering these receptors an important predictive factor and future therapeutic target.
ISSN:	0392-2936