Search Results - "Koulakoff, A."

Astroglial connexin43 contributes to neuronal suffering in a mouse model of Alzheimer’s disease by Yi, C, Mei, X, Ezan, P, Mato, S, Matias, I, Giaume, C, Koulakoff, A

“…In Alzheimer’s disease (AD), astrocyte properties are modified but their involvement in this pathology is only beginning to be appreciated. The expression of…”
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Astroglial connexin immunoreactivity is specifically altered at β-amyloid plaques in β-amyloid precursor protein/presenilin1 mice by Mei, X, Ezan, P, Giaume, C, Koulakoff, A

“…Abstract Activation of astrocytes surrounding amyloid plaques is a hallmark of Alzheimer disease (AD) with consequences yet poorly understood. Astrocytes are…”
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Carbenoxolone blockade of neuronal network activity in culture is not mediated by an action on gap junctions by Rouach, N., Segal, M., Koulakoff, A., Giaume, C., Avignone, E.

“…Spontaneous activity in the central nervous system is strongly suppressed by blockers of gap junctions (GJs), suggesting that GJs contribute to network…”
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Gap junctions and connexin expression in the normal and pathological central nervous system by Rouach, N, Avignone, E, Même, W, Koulakoff, A, Venance, L, Blomstrand, F, Giaume, C

“…Gap junctions are widely expressed in the various cell types of the central nervous system. These specialized membrane intercellular junctions provide the…”
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Hemichannels Are Required for Amyloid β-Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice by Harcha, Paloma A, Vargas, Aníbal, Yi, Chenju, Koulakoff, Annette A, Giaume, Christian, Sáez, Juan C

“…Mast cells (MCs) store an array of proinflammatory mediators in secretory granules that are rapidly released upon activation by diverse conditions including…”
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Astroglial Metabolic Networks Sustain Hippocampal Synaptic Transmission by Rouach, Nathalie, Koulakoff, Annette, Abudara, Veronica, Willecke, Klaus, Giaume, Christian

“…Astrocytes provide metabolic substrates to neurons in an activity-dependent manner. However, the molecular mechanisms involved in this function, as well as its…”
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Distal Transcript of the Dystrophin Gene Initiated from an Alternative First Exon and Encoding a 75-kDa Protein Widely Distributed in Nonmuscle Tissues by Hugnot, J. P., Gilgenkrantz, H., Vincent, N., Chafey, P., Morris, G. E., Monaco, A. P., Berwald-Netter, Y., Koulakoff, A., Kaplan, J. C., Kahn, A., Chelly, J.

“…A transcript generated by the distal part of the Duchenne Muscular Dystrophy (DMD) gene was initially detected in cells where the full size 14-kilobase (kb)…”
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The Glial Voltage-Gated Sodium Channel: Cell- and Tissue-Specific mRNA Expression by Gautron, Sophie, Santos, Georges Dos, Pinto-Henrique, Domingos, Koulakoff, Annette, Gros, François, Berwald-Netter, Yoheved

“…Previous electrophysiological and pharmacological studies on central and peripheral glia revealed the presence of voltage-gated Na channels with properties…”
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Reversible polyglutamylation of α- and β-tubulin and microtubule dynamics in mouse brain neurons by AUDEBERT, S, DESBRUYERES, E, GRUSZCZYNSKI, C, KOULAKOFF, A, GROS, F, DENOULET, P, EDDE, B

“…The relationship between microtubule dynamics and polyglutamylation of tubulin was investigated in young differentiating mouse brain neurons. Selective…”
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Proinflammatory cytokines released from microglia inhibit gap junctions in astrocytes: potentiation by β‐amyloid by Même, William, Calvo, Charles‐Félix, Froger, Nicolas, Ezan, Pascal, Amigou, Edwige, Koulakoff, Annette, Giaume, Christian

“…Brain inflammation is characterized by a reactive gliosis involving the activation of astrocytes and microglia. This process, common to many brain injuries and…”
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Hemichannels Are Required for Amyloid  -Peptide-Induced Degranulation and Are Activated in Brain Mast Cells of APPswe/PS1dE9 Mice by Harcha, P. A., Vargas, A., Yi, C., Koulakoff, A. A., Giaume, C., Saez, J. C.

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Muscarinic receptor profiles of mouse brain astrocytes in culture vary with their tissue of origin but differ from those of neurons by André, C, Dos Santos, G, Koulakoff, A

“…The two main cell populations in brain tissues are neurons and astrocytes. Cultures of both bear muscarinic acetylcholine receptors (mAChRs). Available data…”
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Cultured neurons from mouse brain reproduce the muscarinic receptor profile of their tissue of origin by André, C, Dos Santos, G, Koulakoff, A

“…These studies investigate the regional variations in the muscarinic acetylcholine receptor (mAChR) profiles in neuron populations of the CNS using primary…”
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Astroglial connexin immunoreactivity is specifically altered at b-amyloid plaques in b-amyloid precursor protein/presenilin1 mice by Mei, X, Ezan, P, Giaume, C, Koulakoff, A

“…Activation of astrocytes surrounding amyloid plaques is a hallmark of Alzheimer disease (AD) with consequences yet poorly understood. Astrocytes are…”
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Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons by Francis, F, Koulakoff, A, Boucher, D, Chafey, P, Schaar, B, Vinet, M C, Friocourt, G, McDonnell, N, Reiner, O, Kahn, A, McConnell, S K, Berwald-Netter, Y, Denoulet, P, Chelly, J

“…Recently, we and others reported that the doublecortin gene is responsible for X-linked lissencephaly and subcortical laminar heterotopia. Here, we show that…”
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Doublecortin Functions at the Extremities of Growing Neuronal Processes by Friocourt, Gaëlle, Koulakoff, Annette, Chafey, Philippe, Boucher, Dominique, Fauchereau, Fabien, Chelly, Jamel, Francis, Fiona

“…Type I lissencephaly is a cortical malformation disorder characterized by disorganized cortical layers and gyral abnormalities and associated with severe…”
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Neurotoxin-sensitive sodium channels in neurons developing in vivo and in vitro by Couraud, F, Martin-Moutot, N, Koulakoff, A, Berwald-Netter, Y

“…Fetal mouse brain cells were investigated by 22Na+ flux assays with the aim to determine the ontogenetic time course of appearance of functional…”
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A Novel CNS Gene Required for Neuronal Migration and Involved in X-Linked Subcortical Laminar Heterotopia and Lissencephaly Syndrome by Portes, Vincent des, Pinard, Jean Marc, Billuart, Pierre, Vinet, Marie Claude, Koulakoff, Annette, Carrié, Alain, Gelot, Antoinette, Dupuis, Elisabeth, Motte, Jacques, Berwald-Netter, Yoheved, Catala, Martin, Kahn, Axel, Beldjord, Cherif, Chelly, Jamel

“…X-SCLH/LIS syndrome is a neuronal migration disorder with disruption of the six-layered neocortex. It consists of subcortical laminar heterotopia (SCLH, band…”
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Na+[sodium-ion]-channel-associated scorpion toxin receptor sites as probes for neuronal evolution in vivo and in vitro by Berwald-Netter, Y, Martin-Moutot, N, Koulakoff, A, Couraud, F

“…Purified neurotoxin II of the scorpion Androctonus australis Hector (ScTx) has previously been shown to bind specifically to the Na--ionophore-associated,…”
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Neurons set the tone of gap junctional communication in astrocytic networks by Rouach, Nathalie, Koulakoff, Annette, Giaume, Christian

“…A number of studies have contributed to demonstrate that neurons and astrocytes tightly and actively interact. Indeed, the presence of astrocytes in neuronal…”
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