Search Results - "Kouidou, Sofia"

In silico structural analysis of sequences containing 5-hydroxymethylcytosine reveals its potential as binding regulator for development, ageing and cancer-related transcription factors by Malousi, Andigoni, Andreou, Alexandra-Zoi, Kouidou, Sofia

“…The presence of 5-hydroxymethyl cytosine in DNA has been previously associated with ageing. Using in silico analysis of normal liver samples we presently…”
Get full text

Human epigenome data reveal increased CpG methylation in alternatively spliced sites and putative exonic splicing enhancers by Anastasiadou, Christina, Malousi, Andigoni, Maglaveras, Nicos, Kouidou, Sofia

“…The role of gene body methylation, which represents a major part of methylation in DNA, remains mostly unknown. Evidence based on the CpG distribution…”
Get more information

Recovering circulating extracellular or cell-free RNA from bodily fluids by Tzimagiorgis, Georgios, Michailidou, Evangelia Z, Kritis, Aristidis, Markopoulos, Anastasios K, Kouidou, Sofia

“…Abstract The presence of extracellular circulating or cell-free RNA in biological fluids is becoming a promising diagnostic tool for non invasive and cost…”
Get full text

OPG/RANK/RANKL signaling axis in patients with type I diabetes: Associations with parathormone and vitamin D by Karalazou, Paraskevi, Ntelios, Dimitrios, Chatzopoulou, Fani, Fragou, Aikaterini, Taousani, Maria, Mouzaki, Konstantina, Galli-Tsinopoulou, Assimina, Kouidou, Sofia, Tzimagiorgis, Georgios

“…Type 1 diabetes (T1D) has been associated with a higher fracture risk due to alterations in bone structure and metabolism. On the other hand, the important…”
Get full text

Age-dependent methylation in epigenetic clock CpGs is associated with G-quadruplex, co-transcriptionally formed RNA structures and tentative splice sites by Malousi, Andigoni, Andreou, Alexandra-Zoi, Georgiou, Elisavet, Tzimagiorgis, Georgios, Kovatsi, Leda, Kouidou, Sofia

“…Horvath's epigenetic clock consists of 353 CpGs whose methylation levels can accurately predict the age of individuals. Using bioinformatics analysis, we…”
Get full text

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection: Triggering a Lethal Fight to Keep Control of the Ten-Eleven Translocase (TET)-Associated DNA Demethylation? by Kouidou, Sofia, Malousi, Andigoni, Andreou, Alexandra-Zoi

“…The extended and diverse interference of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in multiple host functions and the diverse associated…”
Get full text

p16 promoter methylation in Pb2+-exposed individuals by Kovatsi, Leda, Georgiou, Elisavet, Ioannou, Antrea, Haitoglou, Costas, Tzimagiorgis, George, Tsoukali, Helen, Kouidou, Sofia

“…Background. One of the principle symptoms of lead poisoning is the development of neurological disorders. Neuronal response is closely related to DNA…”
Get full text

Electroanalytical study of SYBR Green I and ethidium bromide intercalation in methylated and unmethylated amplicons by Ioannou, Andrea K., Alexiadou, Despina K., Kouidou, Sofia A., Voulgaropoulos, Anastasios N., Girousi, Stella Th

“…This work involves the electrochemical study of the interaction of SYBR Green I (SG) with native DNA using differential pulse voltammetry at a carbon paste…”
Get full text

Intronic CpG content and alternative splicing in human genes containing a single cassette exon by Malousi, Andigoni, Maglaveras, Nicos, Kouidou, Sofia

“…Clinical data provide evidence for the association of missplicing with methyl-binding protein mutations and inhibition of methylation. In this study, we…”
Get full text

DNA hypermethylation of alternatively spliced and repeat sequences in humans by Malousi, Andigoni, Kouidou, Sofia

“…DNA methylation is presently accepted as a tentative regulatory parameter in splicing. Recently, we reported significant methylation differences among various…”
Get full text

MeinteR: A framework to prioritize DNA methylation aberrations based on conformational and cis-regulatory element enrichment by Malousi, Andigoni, Kouidou, Sofia, Tsagiopoulou, Maria, Papakonstantinou, Nikos, Bouras, Emmanouil, Georgiou, Elisavet, Tzimagiorgis, Georgios, Stamatopoulos, Kostas

“…DNA methylation studies have been reformed with the advent of single-base resolution arrays and bisulfite sequencing methods, enabling deeper investigation of…”
Get full text

Salivary mRNA markers having the potential to detect oral squamous cell carcinoma segregated from oral leukoplakia with dysplasia by Michailidou, Evangelia, Tzimagiorgis, Georgios, Chatzopoulou, Fani, Vahtsevanos, Konstantinos, Antoniadis, Konstantinos, Kouidou, Sofia, Markopoulos, Anastasios, Antoniades, Dimitrios

“…Highlights • Evaluation of the presence of extracellular IL-1B, IL-8, OAZ and SAT mRNAs in saliva. • Employment of saliva in early detection of oral squamous…”
Get full text

Effect of chronic heroin and cocaine administration on global DNA methylation in brain and liver by Fragou, Domniki, Zanos, Panos, Kouidou, Sofia, Njau, Samuel, Kitchen, Ian, Bailey, Alexis, Kovatsi, Leda

“…► This is the first report on global DNA methylation in brain and liver following chronic heroin or cocaine treatment. ► The % 5-MedC content of DNA is higher…”
Get full text

Elevated plasma levels of miR-29a are associated with hemolysis in patients with hypertrophic cardiomyopathy by Ntelios, Dimitrios, Meditskou, Soultana, Efthimiadis, Georgios, Pitsis, Antonios, Nikolakaki, Eleni, Girtovitis, Fotios, Parcharidou, Despoina, Zegkos, Thomas, Kouidou, Sofia, Karvounis, Haralampos, Tzimagiorgis, Georgios

“…miR-29a is a small non-coding RNA that is known to repress collagen synthesis. Interestingly, elevated plasma miR-29a was reported to correlate with pronounced…”
Get full text

Increased Δ133p53 mRNA in lung carcinoma corresponds with reduction of p21 expression by Fragou, Aikaterini, Tzimagiorgis, Georgios, Karageorgopoulos, Christos, Barbetakis, Nikolaos, Lazopoulos, Axilleas, Papaioannou, Maria, Haitoglou, Costas, Kouidou, Sofia

“…Modification of p53 expression levels and its principle apoptosis and cell cycle regulatory partners, mouse double minute 2 homolog (MDM-2) and p21, has been…”
Get full text

Epigenetic mechanisms in metal toxicity by Fragou, Domniki, Fragou, Aikaterini, Kouidou, Sofia, Njau, Samuel, Kovatsi, Leda

“…The true understanding of epigenetics evolved over time as our knowledge on DNA methylation and chromatin modifications and their effects on gene expression…”
Get full text

Li-Fraumeni and Li-Fraumeni-like syndrome mutations in p53 are associated with exonic methylation and splicing regulatory elements by Kouidou, Sofia, Malousi, Andigoni, Maglaveras, Nicos

“…Mutations in codon 133 of p53, which cause the loss of the Δ133 isoform(s) expression, are very frequent in the Li–Fraumeni (LF) and Li–Fraumeni‐like (LFL)…”
Get full text

Epigenetically modified nucleotides in chronic heroin and cocaine treated mice by Chao, Mu-Rong, Fragou, Domniki, Zanos, Panos, Hu, Chiung-Wen, Bailey, Alexis, Kouidou, Sofia, Kovatsi, Leda

“…•Determination of modified bases in liver and brain of cocaine or heroin treated mice.•Global 5-methylcytosine levels are unaffected by heroin or cocaine…”
Get full text

Electroanalytical study of proflavine intercalation in 5-methyl or inosine-containing amplicons by Alexiadou, Despina K, Ioannou, Andrea K, Kouidou-Andreou, Sofia A, Voulgaropoulos, Anastasios N, Girousi, Stella Th

“…Amplicons corresponding to the GC-rich p53 exon 5 and its analogues, synthesized by substituting 60% of cytosine by 5-methyl-cytosine, or 60% of guanosine by…”
Get full text

GREMET: An integrative tool for the prediction of mutation effects on gene regulation by Athanasiadis, Polykarpos, Malousi, Andigoni, Kouidou, Sofia, Maglaveras, Nicos

“…Abstract The identification of thousands of mutations yearly has put new challenges to researchers who are interested in fast and effective annotation as well…”
Get full text