Search Results - "Kotze, Andrew"
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A journey through 50 years of research relevant to the control of gastrointestinal nematodes in ruminant livestock and thoughts on future directions
Published in International journal for parasitology (01-12-2021)“…[Display omitted] •We provide an historical perspective, source of references and framework for deeper reading.•Anthelmintic use, discovery and resistance are…”
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Cross-resistance patterns in field strains of the sheep blowfly following laboratory-based selection pressure with dicyclanil or imidacloprid
Published in Veterinary parasitology (01-12-2024)“…Control of the sheep blowfly relies largely on the use of insecticides applied prophylactically in advance of expected fly activity. However, the blowfly has…”
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Reduced synergistic efficacy of piperonyl butoxide in combination with alpha-cypermethrin in vitro in an insecticide-resistant strain of the sheep blowfly, Lucilia cuprina
Published in Veterinary parasitology (01-05-2023)“…Control of flystrike on sheep relies on the use of insecticides. The present study used in vitro assays to examine the potential for increasing the efficacy of…”
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A novel high throughput assay for anthelmintic drug screening and resistance diagnosis by real-time monitoring of parasite motility
Published in PLoS neglected tropical diseases (16-11-2010)“…Helminth parasites cause untold morbidity and mortality to billions of people and livestock. Anthelmintic drugs are available but resistance is a problem in…”
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Overcoming insecticide resistance through computational inhibitor design
Published in Proceedings of the National Academy of Sciences - PNAS (15-10-2019)“…Insecticides allow control of agricultural pests and disease vectors and are vital for global food security and health. The evolution of resistance to…”
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Challenges and opportunities for the adoption of molecular diagnostics for anthelmintic resistance
Published in International journal for parasitology -- drugs and drug resistance (01-12-2020)“…Anthelmintic resistance is a significant threat to livestock production systems worldwide and is emerging as an important issue in companion animal parasite…”
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Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic
Published in PLoS neglected tropical diseases (01-03-2011)“…The three major soil-transmitted helminths (STH) Ascaris lumbricoides, Trichuris trichiura and Necator americanus/Ancylostoma duodenale are among the most…”
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In vitro insecticide resistance patterns in field strains of the sheep blowfly, Lucilia cuprina
Published in Veterinary parasitology (01-06-2024)“…The control of the sheep blowfly relies on the use of insecticides. There have been several reports of in vitro and in vivo resistance to the most widely-used…”
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Recent advances in candidate-gene and whole-genome approaches to the discovery of anthelmintic resistance markers and the description of drug/receptor interactions
Published in International journal for parasitology (01-12-2014)“…•We report on the Consortium for Anthelmintic Resistance and Susceptibility 2013 meeting.•Recent advances in the identification of markers for anthelmintic…”
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Assessment of anthelmintic efficacy of mebendazole in school children in six countries where soil-transmitted helminths are endemic
Published in PLoS neglected tropical diseases (01-10-2014)“…Robust reference values for fecal egg count reduction (FECR) rates of the most widely used anthelmintic drugs in preventive chemotherapy (PC) programs for…”
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A comparison of the sensitivity and fecal egg counts of the McMaster egg counting and Kato-Katz thick smear methods for soil-transmitted helminths
Published in PLoS neglected tropical diseases (01-06-2011)“…The Kato-Katz thick smear (Kato-Katz) is the diagnostic method recommended for monitoring large-scale treatment programs implemented for the control of…”
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Response of drug-susceptible and -resistant Haemonchus contortus larvae to monepantel and abamectin alone or in combination in vitro
Published in Veterinary parasitology (15-01-2018)“…[Display omitted] •We measured effect of an abamectin:monepantel combination on Haemonchus contortus larval development in vitro.•Resistance to the combination…”
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The use of the larval development assay for predicting the in vivo efficacy of levamisole against Haemonchus contortus and Trichostrongylus colubriformis
Published in Veterinary parasitology (30-08-2018)“…•Sensitivity of nematode larvae to levamisole measured in larval development assay.•Susceptible and resistant Haemonchus contortus and Trichostrongylus…”
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Effects of third generation P-glycoprotein inhibitors on the sensitivity of drug-resistant and -susceptible isolates of Haemonchus contortus to anthelmintics in vitro
Published in Veterinary parasitology (30-06-2015)“…•Measured effects of third generation P-gp inhibitors on anthelmintic sensitivity in Haemonchus contortus in vitro.•Zosuquidar and tariquidar synergised…”
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Resistance to dicyclanil and imidacloprid in the sheep blowfly, Lucilia cuprina, in Australia
Published in Pest management science (01-10-2022)“…Background The sheep blowfly, Lucila cuprina, is a myiasis‐causing parasite responsible for significant production losses and welfare issues for the Australian…”
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Venom composition and bioactive RF-amide peptide toxins of the saddleback caterpillar, Acharia stimulea (Lepidoptera: Limacodidae)
Published in Biochemical pharmacology (01-07-2023)“…[Display omitted] Limacodidae is a family of lepidopteran insects comprising >1500 species. More than half of these species produce pain-inducing defensive…”
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Is anthelmintic resistance a concern for the control of human soil-transmitted helminths?
Published in International journal for parasitology -- drugs and drug resistance (01-12-2011)“…[Display omitted] ► Large variation in efficacy across treatment and drug dose regimens and STH. ► Efficacy studies are profoundly confounded. ► There is no…”
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Larval development assays reveal the presence of sub-populations showing high- and low-level resistance in a monepantel (Zolvix®)-resistant isolate of Haemonchus contortus
Published in Veterinary parasitology (15-04-2016)“…•Larval development assay able to define sensitivity to monepantel in Haemonchus contortus.•Resistant isolate readily distinguishable from susceptible…”
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Multipurpose peptides: The venoms of Amazonian stinging ants contain anthelmintic ponericins with diverse predatory and defensive activities
Published in Biochemical pharmacology (01-10-2021)“…[Display omitted] In the face of increasing drug resistance, the development of new anthelmintics is critical for controlling nematodes that parasitise…”
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The antitrypanosomal diarylamidines, diminazene and pentamidine, show anthelmintic activity against Haemonchus contortus in vitro
Published in Veterinary parasitology (01-06-2019)“…•We examined the in vitro anthelmintic activity of diarylamidine compounds.•Pentamidine and diminazene inhibited Haemonchus contortus larval…”
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