Search Results - "Kotzé, Awie"

Beneficial Pharmacokinetic Drug Interactions: A Tool to Improve the Bioavailability of Poorly Permeable Drugs by Gerber, Werner, Steyn, Johan D, Kotzé, Awie F, Hamman, Josias H

“…Simultaneous oral intake of herbs, supplements, foods and drugs with other drug(s) may result in pharmacokinetic or pharmacodynamic interactions with the…”
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Effect of moisture content, temperature and exposure time on the physical stability of chitosan powder and tablets by Viljoen, Joe M., Steenekamp, Jan H., Marais, Andries F., Kotzé, Awie F.

“…Abstract Context: Chitosan does not rank highly regarding its employment as tablet filler due to certain limitations. Undesirable properties that limit its…”
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Applications of lipid based formulation technologies in the delivery of biotechnology-based therapeutics by du Plessis, Lissinda H, Marais, Etienne B, Mohammed, Faruq, Kotzé, Awie F

“…In the last decades several new biotechnologically-based therapeutics have been developed due to progress in genetic engineering. A growing challenge facing…”
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Oral delivery of peptide drugs: barriers and developments by Hamman, Josias H, Enslin, Gill M, Kotzé, Awie F

“…A wide variety of peptide drugs are now produced on a commercial scale as a result of advances in the biotechnology field. Most of these therapeutic peptides…”
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Formulation and evaluation of Pheroid vesicles containing mefloquine for the treatment of malaria by du Plessis, Lissinda H., Helena, Chrizaan, van Huysteen, Este, Wiesner, Lubbe, Kotzé, Awie F.

“…Objectives Mefloquine (MQ) is an antimalarial drug with high efficacy, often used in the treatment and chemoprophylaxis of malaria. However, it has low…”
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A toxicity profile of the Pheroid® technology in rodents by Kleynhans, Janke, Elgar, Dale, Ebenhan, Thomas, Zeevaart, Jan Rijn, Kotzé, Awie, Grobler, Anne

“…[Display omitted] •Acute administration of 2000 mg/kg of the Pheroid® delivery system was tolerated upon intravenous administration in BALB/c mice and…”
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In vitro activity of Pheroid vesicles containing antibiotics against Plasmodium falciparum by Du Plessis, Lissinda H, van Niekerk, Anel C, Maritz, Marlene M, Kotzé, Awie F

“…The macrolide antibiotics, erythromycin and azithromycin, have been studied for their potential antimalarial activity, but only modest activity has been…”
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Nasal and rectal delivery of insulin with chitosan and N-trimethyl chitosan chloride by du Plessis, Lissinda H, Kotzé, Awie F, Junginger, Hans E

“…The aim of this study was to evaluate the ability of TMC, with different degrees of quaternization, to increase insulin absorption in vivo following nasal and…”
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Permeation enhancement effects of leaf materials from different aloe species on in vitro and ex vivo nasal epithelial models by Gerber, Werner, Steyn, Dewald, Kotzé, Awie, Svitina, Hanna, Weldon, Ché, Hamman, Josias

“…Introduction: The nasal route of drug administration offers an alternative way for oral drug delivery and has the benefit of avoiding first-pass metabolism…”
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Comparison of the effect of different chitosan salts and N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2) by Kotzé, Awie F, Lueßen, Henrik L, de Leeuw, Bas J, de Boer, (A)Bert G, Coos Verhoef, J, Junginger, Hans E

“…A partially quaternized chitosan derivative, N-trimethyl chitosan chloride (TMC) (degree of quaternization 12.28%), was synthesized and the effects of this…”
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Intestinal Drug Absorption Enhancers: Synergistic Effects of Combinations by Enslin, Gill M., Hamman, Josias H., Kotzé, Awie F.

“…Although many absorption enhancers have been investigated, very few are used clinically. A need exists therefore for more effective absorption enhancers. The…”
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Capsaicin and Piperine as Functional Excipients for Improved Drug Delivery across Nasal Epithelial Models by Gerber, Werner, Steyn, Dewald, Kotzé, Awie, Svitina, Hanna, Weldon, Ché, Hamman, Josias

“…The fruit from various pepper plants has been employed for the seasoning of food, as perfuming agents, and also as traditional medicines. Phytochemicals…”
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Comparison of RPMI 2650 cell layers and excised sheep nasal epithelial tissues in terms of nasal drug delivery and immunocytochemistry properties by Gerber, Werner, Svitina, Hanna, Steyn, Dewald, Peterson, Bianca, Kotzé, Awie, Weldon, Ché, Hamman, Josias H.

“…Nasal drug administration has been identified as a potential alternative to oral drug administration, especially for systemic delivery of large molecular…”
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Absorption of the novel artemisinin derivatives artemisone and artemiside: Potential application of Pheroid™ technology by Steyn, J. Dewald, Wiesner, Lubbe, du Plessis, Lissinda H., Grobler, Anne F., Smith, Peter J., Chan, Wing-Chi, Haynes, Richard K., Kotzé, Awie F.

“…Artemisinins have low aqueous solubility that results in poor and erratic absorption upon oral administration. The poor solubility and erratic absorption…”
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Nasal delivery of recombinant human growth hormone: in vivo evaluation with Pheroid technology and N-trimethyl chitosan chloride by Steyn, Dewald, du Plessis, Lissinda, Kotzé, Awie

“…It was the aim of this study to investigate the possible enhancement of the absorption of recombinant human growth hormone (rhGH) in the nasal cavity, in the…”
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Direct compression of chitosan: process and formulation factors to improve powder flow and tablet performance by Buys, Gerhard M, du Plessis, Lissinda H, Marais, Andries F, Kotze, Awie F, Hamman, Josias H

“…Chitosan is a polymer derived from chitin that is widely available at relatively low cost, but due to compression challenges it has limited application for the…”
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Evaluation of the Mucoadhesive Properties of N-Trimethyl Chitosan Chloride by Snyman, Dewald, Hamman, Josias H., Kotze, Awie F.

“…Abstract Previous studies have established that N-trimethyl chitosan chloride (TMC) is a potent absorption enhancer for peptides and large hydrophilic…”
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N-trimethyl chitosan chloride as a potential absorption enhancer across mucosal surfaces : In vitro evaluation in intestinal epithelial cells (Caco-2) by KOTZE, A. F, LUESSEN, H. L, DE LEEUW, B. J, DE BOER, A. B. G, VERHOEF, J. C, JUNGINGER, H. E

“…Previous studies have established that chitosan hydrochloride and glutamate are potent absorption enhancers for large hydrophilic compounds across mucosal…”
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Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2) by Kotzé, A F, Thanou, M M, Luebetaen, H L, de Boer, A G, Verhoef, J C, Junginger, H E

“…Previous studies have established that a partially quaternized derivative of chitosan, N-trimethyl chitosan chloride (TMC), can be used as an absorption…”
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Effect of the degree of quaternization of N-trimethyl chitosan chloride on the permeability of intestinal epithelial cells (Caco-2) by Kotzé, Awie F, Thanou, Maya M, Lueßen, Henrik L, de Boer, (A)Bert G, Verhoef, J.Coos, Junginger, Hans E

“…N-trimethyl chitosan chloride (TMC), a partially quaternized derivative of chitosan with superior water solubility, was synthesized with different degrees of…”
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