Search Results - "Kotz, Joanne"

Harnessing Connectivity in a Large-Scale Small-Molecule Sensitivity Dataset by Seashore-Ludlow, Brinton, Rees, Matthew G, Cheah, Jaime H, Cokol, Murat, Price, Edmund V, Coletti, Matthew E, Jones, Victor, Bodycombe, Nicole E, Soule, Christian K, Gould, Joshua, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Wawer, Mathias J, Kuru, Nurdan, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Bittker, Joshua A, Palmer, Michelle, Bradner, James E, Shamji, Alykhan F, Clemons, Paul A, Schreiber, Stuart L

“…Identifying genetic alterations that prime a cancer cell to respond to a particular therapeutic agent can facilitate the development of precision cancer…”
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Small-molecule targeting of brachyury transcription factor addiction in chordoma by Sharifnia, Tanaz, Wawer, Mathias J., Chen, Ting, Huang, Qing-Yuan, Weir, Barbara A., Sizemore, Ann, Lawlor, Matthew A., Goodale, Amy, Cowley, Glenn S., Vazquez, Francisca, Ott, Christopher J., Francis, Joshua M., Sassi, Slim, Cogswell, Patricia, Sheppard, Hadley E., Zhang, Tinghu, Gray, Nathanael S., Clarke, Paul A., Blagg, Julian, Workman, Paul, Sommer, Josh, Hornicek, Francis, Root, David E., Hahn, William C., Bradner, James E., Wong, Kwok K., Clemons, Paul A., Lin, Charles Y., Kotz, Joanne D., Schreiber, Stuart L.

“…Chordoma is a primary bone cancer with no approved therapy 1 . The identification of therapeutic targets in this disease has been challenging due to the…”
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Correlating chemical sensitivity and basal gene expression reveals mechanism of action by Rees, Matthew G, Seashore-Ludlow, Brinton, Cheah, Jaime H, Adams, Drew J, Price, Edmund V, Gill, Shubhroz, Javaid, Sarah, Coletti, Matthew E, Jones, Victor L, Bodycombe, Nicole E, Soule, Christian K, Alexander, Benjamin, Li, Ava, Montgomery, Philip, Kotz, Joanne D, Hon, C Suk-Yee, Munoz, Benito, Liefeld, Ted, Dančík, Vlado, Haber, Daniel A, Clish, Clary B, Bittker, Joshua A, Palmer, Michelle, Wagner, Bridget K, Clemons, Paul A, Shamji, Alykhan F, Schreiber, Stuart L

“…A computational tool provides a systematic approach to determine the mechanisms of action of small molecules by examining correlations between basal gene…”
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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes by Schreiber, Stuart L., Kotz, Joanne D., Li, Min, Aubé, Jeffrey, Austin, Christopher P., Reed, John C., Rosen, Hugh, White, E. Lucile, Sklar, Larry A., Lindsley, Craig W., Alexander, Benjamin R., Bittker, Joshua A., Clemons, Paul A., de Souza, Andrea, Foley, Michael A., Palmer, Michelle, Shamji, Alykhan F., Wawer, Mathias J., McManus, Owen, Wu, Meng, Zou, Beiyan, Yu, Haibo, Golden, Jennifer E., Schoenen, Frank J., Simeonov, Anton, Jadhav, Ajit, Jackson, Michael R., Pinkerton, Anthony B., Chung, Thomas D.Y., Griffin, Patrick R., Cravatt, Benjamin F., Hodder, Peter S., Roush, William R., Roberts, Edward, Chung, Dong-Hoon, Jonsson, Colleen B., Noah, James W., Severson, William E., Ananthan, Subramaniam, Edwards, Bruce, Oprea, Tudor I., Conn, P. Jeffrey, Hopkins, Corey R., Wood, Michael R., Stauffer, Shaun R., Emmitte, Kyle A., Brady, Linda S., Driscoll, Jamie, Li, Ingrid Y., Loomis, Carson R., Margolis, Ronald N., Michelotti, Enrique, Perry, Mary E., Pillai, Ajay, Yao, Yong

“…Small-molecule probes can illuminate biological processes and aid in the assessment of emerging therapeutic targets by perturbing biological systems in a…”
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Inhibition of Dihydroorotate Dehydrogenase Overcomes Differentiation Blockade in Acute Myeloid Leukemia by Sykes, David B., Kfoury, Youmna S., Mercier, François E., Wawer, Mathias J., Law, Jason M., Haynes, Mark K., Lewis, Timothy A., Schajnovitz, Amir, Jain, Esha, Lee, Dongjun, Meyer, Hanna, Pierce, Kerry A., Tolliday, Nicola J., Waller, Anna, Ferrara, Steven J., Eheim, Ashley L., Stoeckigt, Detlef, Maxcy, Katrina L., Cobert, Julien M., Bachand, Jacqueline, Szekely, Brian A., Mukherjee, Siddhartha, Sklar, Larry A., Kotz, Joanne D., Clish, Clary B., Sadreyev, Ruslan I., Clemons, Paul A., Janzer, Andreas, Schreiber, Stuart L., Scadden, David T.

“…While acute myeloid leukemia (AML) comprises many disparate genetic subtypes, one shared hallmark is the arrest of leukemic myeloblasts at an immature and…”
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Collaboration for Alzheimer's Prevention: Principles to guide data and sample sharing in preclinical Alzheimer's disease trials by Weninger, Stacie, Carrillo, Maria C, Dunn, Billy, Aisen, Paul S, Bateman, Randall J, Kotz, Joanne D, Langbaum, Jessica B, Mills, Susan L, Reiman, Eric M, Sperling, Reisa, Santacruz, Anna M, Tariot, Pierre N, Welsh-Bohmer, Kathleen A

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The gout pipeline crystallizes by Kotz, Joanne

“…The gout space is heating up, but is there sufficient room in the market to accommodate multiple new therapeutics?…”
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The gout pipeline crystallizes: the gout space is heating up, but is there sufficient room in the market to accommodate multiple new therapeutics? by Kotz, Joanne

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Drug discovery: Polypharmacology on the fly by Kotz, Joanne

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Polypharmacology on the fly by Kotz, Joanne

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Chemical probes: PARP family portraits by Kotz, Joanne

“…Human poly-ADP-ribose polymerases (PARPs) share a common catalytic domain that facilitates the transfer of ADP-ribose. Perhaps the best-studied PARP family…”
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PARP family portraits by Kotz, Joanne

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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway by Viswanathan, Vasanthi S., Ryan, Matthew J., Dhruv, Harshil D., Gill, Shubhroz, Eichhoff, Ossia M., Seashore-Ludlow, Brinton, Kaffenberger, Samuel D., Eaton, John K., Shimada, Kenichi, Aguirre, Andrew J., Viswanathan, Srinivas R., Chattopadhyay, Shrikanta, Tamayo, Pablo, Yang, Wan Seok, Rees, Matthew G., Chen, Sixun, Boskovic, Zarko V., Javaid, Sarah, Huang, Cherrie, Wu, Xiaoyun, Tseng, Yuen-Yi, Roider, Elisabeth M., Gao, Dong, Cleary, James M., Wolpin, Brian M., Mesirov, Jill P., Haber, Daniel A., Engelman, Jeffrey A., Boehm, Jesse S., Kotz, Joanne D., Hon, Cindy S., Chen, Yu, Hahn, William C., Levesque, Mitchell P., Doench, John G., Berens, Michael E., Shamji, Alykhan F., Clemons, Paul A., Stockwell, Brent R., Schreiber, Stuart L.

“…Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid…”
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The promise and peril of chemical probes by Arrowsmith, Cheryl H, Audia, James E, Austin, Christopher, Baell, Jonathan, Bennett, Jonathan, Blagg, Julian, Bountra, Chas, Brennan, Paul E, Brown, Peter J, Bunnage, Mark E, Buser-Doepner, Carolyn, Campbell, Robert M, Carter, Adrian J, Cohen, Philip, Copeland, Robert A, Cravatt, Ben, Dahlin, Jayme L, Dhanak, Dashyant, Edwards, Aled M, Frederiksen, Mathias, Frye, Stephen V, Gray, Nathanael, Grimshaw, Charles E, Hepworth, David, Howe, Trevor, Huber, Kilian V M, Jin, Jian, Knapp, Stefan, Kotz, Joanne D, Kruger, Ryan G, Lowe, Derek, Mader, Mary M, Marsden, Brian, Mueller-Fahrnow, Anke, Müller, Susanne, O'Hagan, Ronan C, Overington, John P, Owen, Dafydd R, Rosenberg, Saul H, Ross, Ruth, Roth, Bryan, Schapira, Matthieu, Schreiber, Stuart L, Shoichet, Brian, Sundström, Michael, Superti-Furga, Giulio, Taunton, Jack, Toledo-Sherman, Leticia, Walpole, Chris, Walters, Michael A, Willson, Timothy M, Workman, Paul, Young, Robert N, Zuercher, William J

“…Chemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of poor quality or that are used incorrectly generate…”
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Scientists Without Borders by Kotz, Joanne

“…A new web portal helps connect scientists and coordinate scientific efforts to address the challenges of the developing world…”
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Ivano Bertini by Kotz, Joanne

“…Building on his contributions to NMR methodologies for studying metalloproteins, Bertini has been instrumental in bringing together inorganic chemists and…”
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Sustainable Sciences Institute by Kotz, Joanne

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Chemical biology at the Broad Institute by Kotz, Joanne

“…Basic biomedical research at the Broad Institute is directed towards genome biology and cell circuits, medical and population genetics, computational biology…”
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Phage‐display as a tool for quantifying protein stability determinants by Kotz, Joanne D., Bond, Christopher J., Cochran, Andrea G.

“…To address questions of protein stability, researchers have increasingly turned to combinatorial approaches that permit the rapid analysis of libraries of…”
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EuCheMS by Kotz, Joanne

“…The newly formed European Association for Chemical and Molecular Sciences (EuCheMS) is bridging national cultures to bring European chemists together. The…”
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