Search Results - "Kottur, Jithesh"

Nucleic acid mediated activation of a short prokaryotic Argonaute immune system by Kottur, Jithesh, Malik, Radhika, Aggarwal, Aneel K.

“…A short prokaryotic Argonaute (pAgo) TIR-APAZ (SPARTA) defense system, activated by invading DNA to unleash its TIR domain for NAD(P) + hydrolysis, was…”
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Reactive Oxygen Species Play an Important Role in the Bactericidal Activity of Quinolone Antibiotics by Kottur, Jithesh, Nair, Deepak T.

“…Recent studies posit that reactive oxygen species (ROS) contribute to the cell lethality of bactericidal antibiotics. However, this conjecture has been…”
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A polar filter in DNA polymerases prevents ribonucleotide incorporation by Johnson, Mary K, Kottur, Jithesh, Nair, Deepak T

“…Abstract The presence of ribonucleotides in DNA can lead to genomic instability and cellular lethality. To prevent adventitious rNTP incorporation, the…”
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Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation by Quintana-Feliciano, Richard, Kottur, Jithesh, Ni, Mi, Ghosh, Rikhia, Salas-Estrada, Leslie, Ahlsen, Goran, Rechkoblit, Olga, Shapiro, Lawrence, Filizola, Marta, Fang, Gang, Aggarwal, Aneel K.

“…Burkholderia cenocepacia is an opportunistic and infective bacterium containing an orphan DNA methyltransferase called M.BceJIV with roles in regulating gene…”
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Fast native-SAD phasing for routine macromolecular structure determination by Weinert, Tobias, Olieric, Vincent, Waltersperger, Sandro, Panepucci, Ezequiel, Chen, Lirong, Zhang, Hua, Zhou, Dayong, Rose, John, Ebihara, Akio, Kuramitsu, Seiki, Li, Dianfan, Howe, Nicole, Schnapp, Gisela, Pautsch, Alexander, Bargsten, Katja, Prota, Andrea E, Surana, Parag, Kottur, Jithesh, Nair, Deepak T, Basilico, Federica, Cecatiello, Valentina, Pasqualato, Sebastiano, Boland, Andreas, Weichenrieder, Oliver, Wang, Bi-Cheng, Steinmetz, Michel O, Caffrey, Martin, Wang, Meitian

“…A native-SAD (single-wavelength anomalous diffraction) data collection strategy enables phasing using anomalous signal from a single native crystal,…”
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Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals by Kottur, Jithesh, White, Kris M, Rodriguez, M Luis, Rechkoblit, Olga, Quintana-Feliciano, Richard, Nayar, Ahana, García-Sastre, Adolfo, Aggarwal, Aneel K

“…The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2's nsp14 protein is essential for viral replication and is a target for the development of new…”
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Pyrophosphate hydrolysis is an intrinsic and critical step of the DNA synthesis reaction by Kottur, Jithesh, Nair, Deepak T

“…Abstract DNA synthesis by DNA polymerases (dPols) is central to duplication and maintenance of the genome in all living organisms. dPols catalyze the formation…”
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High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development by Kottur, Jithesh, Rechkoblit, Olga, Quintana-Feliciano, Richard, Sciaky, Daniela, Aggarwal, Aneel K.

“…Emergence of SARS-CoV-2 coronavirus has led to millions of deaths globally. We present three high-resolution crystal structures of the SARS-CoV-2 nsp14…”
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Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides by Rechkoblit, Olga, Sciaky, Daniela, Kreitler, Dale F., Buku, Angeliki, Kottur, Jithesh, Aggarwal, Aneel K.

“…The bacterial cyclic oligonucleotide-based antiphage signaling system (CBASS) is similar to the cGAS–STING system in humans, containing an enzyme that…”
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Expression and purification of organic solvent stable lipase from soil metagenomic library by Khan, Mahejibin, Jithesh, Kottur

“…Gene for organic solvent stable lipase was overexpressed from soil metagenomic library. The clone with maximum activity was selected, and enzyme was purified…”
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A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models by Yu, Xufen, Li, Dongxu, Kottur, Jithesh, Shen, Yudao, Kim, Huen Suk, Park, Kwang-Su, Tsai, Yi-Hsuan, Gong, Weida, Wang, Jun, Suzuki, Kyogo, Parker, Joel, Herring, Laura, Kaniskan, H Ümit, Cai, Ling, Jain, Rinku, Liu, Jing, Aggarwal, Aneel K, Wang, Gang Greg, Jin, Jian

“…Interactions between WD40 repeat domain protein 5 (WDR5) and its various partners such as mixed lineage leukemia (MLL) and c-MYC are essential for sustaining…”
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Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals by Kottur, Jithesh, White, Kris M., Rodriguez, M. Luis, Rechkoblit, Olga, Quintana-Feliciano, Richard, Nayar, Ahana, García-Sastre, Adolfo, Aggarwal, Aneel K., Rey, Félix A.

“…The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2’s nsp14 protein is essential for viral replication and is a target for the development of new…”
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Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals by Kottur, Jithesh, White, Kris M., Rodriguez, M. Luis, Rechkoblit, Olga, Quintana-Feliciano, Richard, Nayar, Ahana, García-Sastre, Adolfo, Aggarwal, Aneel K., Rey, ed., Félix A.

“…The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2’s nsp14 protein is essential for viral replication and is a target for the development of new…”
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Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer by Yu, Xufen, Li, Dongxu, Kottur, Jithesh, Kim, Huen Suk, Herring, Laura E., Yu, Yao, Xie, Ling, Hu, Xiaoping, Chen, Xian, Cai, Ling, Liu, Jing, Aggarwal, Aneel K., Wang, Gang Greg, Jin, Jian

“…As a core chromatin-regulatory scaffolding protein, WDR5 mediates numerous protein–protein interactions (PPIs) with other partner oncoproteins. However,…”
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Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic by Li, Dongxu, Yu, Xufen, Kottur, Jithesh, Gong, Weida, Zhang, Zhao, Storey, Aaron J., Tsai, Yi-Hsuan, Uryu, Hidetaka, Shen, Yudao, Byrum, Stephanie D., Edmondson, Rick D., Mackintosh, Samuel G., Cai, Ling, Liu, Zhijie, Aggarwal, Aneel K., Tackett, Alan J., Liu, Jing, Jin, Jian, Wang, Gang Greg

“…WD repeat domain 5 (WDR5), an integral component of the MLL/KMT2A lysine methyltransferase complex, is critically involved in oncogenesis and represents an…”
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A rescue act: Translesion DNA synthesis past N 2 ‐deoxyguanosine adducts by Nair, Deepak T., Kottur, Jithesh, Sharma, Rahul

“…Abstract Genomic DNA is continually subjected to a number of chemical insults that result in the formation of modified nucleotides—termed as DNA lesions. The N…”
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A strategically located serine residue is critical for the mutator activity of DNA polymerase IV from Escherichia coli by Sharma, Amit, Kottur, Jithesh, Narayanan, Naveen, Nair, Deepak T

“…The Y-family DNA polymerase IV or PolIV (Escherichia coli) is the founding member of the DinB family and is known to play an important role in stress-induced…”
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A rescue act: Translesion DNA synthesis past N super(2)-deoxyguanosine adducts by Nair, Deepak T, Kottur, Jithesh, Sharma, Rahul

“…Genomic DNA is continually subjected to a number of chemical insults that result in the formation of modified nucleotides-termed as DNA lesions. The N…”
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H19 influenza A virus exhibits species-specific MHC class II receptor usage by Karakus, Umut, Mena, Ignacio, Kottur, Jithesh, El Zahed, Sara S, Seoane, Rocío, Yildiz, Soner, Chen, Leanne, Plancarte, Magdalena, Lindsay, LeAnn, Halpin, Rebecca, Stockwell, Timothy B, Wentworth, David E, Boons, Geert-Jan, Krammer, Florian, Stertz, Silke, Boyce, Walter, de Vries, Robert P, Aggarwal, Aneel K, García-Sastre, Adolfo

“…Avian influenza A virus (IAV) surveillance in Northern California, USA, revealed unique IAV hemagglutinin (HA) genome sequences in cloacal swabs from lesser…”
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A rescue act: Translesion DNA synthesis past N(2) -deoxyguanosine adducts by Nair, Deepak T, Kottur, Jithesh, Sharma, Rahul

“…Genomic DNA is continually subjected to a number of chemical insults that result in the formation of modified nucleotides--termed as DNA lesions. The N(2)…”
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