Search Results - "Kott, Katharine A"

A hierarchical approach to removal of unwanted variation for large-scale metabolomics data by Kim, Taiyun, Tang, Owen, Vernon, Stephen T., Kott, Katharine A., Koay, Yen Chin, Park, John, James, David E., Grieve, Stuart M., Speed, Terence P., Yang, Pengyi, Figtree, Gemma A., O’Sullivan, John F., Yang, Jean Yee Hwa

“…Liquid chromatography-mass spectrometry-based metabolomics studies are increasingly applied to large population cohorts, which run for several weeks or even…”
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High-Throughput Measure of Mitochondrial Superoxide Levels as a Marker of Coronary Artery Disease to Accelerate Drug Translation in Patient-Derived Endothelial Cells Using Opera Phenix ® Technology by Lee, Weiqian E, Besnier, Marie, Genetzakis, Elijah, Tang, Owen, Kott, Katharine A, Vernon, Stephen T, Gray, Michael P, Grieve, Stuart M, Kassiou, Michael, Figtree, Gemma A

“…Improved human-relevant preclinical models of coronary artery disease (CAD) are needed to improve translational research and drug discovery. Mitochondrial…”
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Single-Cell Immune Profiling in Coronary Artery Disease: The Role of State-of-the-Art Immunophenotyping With Mass Cytometry in the Diagnosis of Atherosclerosis by Kott, Katharine A, Vernon, Stephen T, Hansen, Thomas, de Dreu, Macha, Das, Souvik K, Powell, Joseph, Fazekas de St Groth, Barbara, Di Bartolo, Belinda A, McGuire, Helen M, Figtree, Gemma A

“…Coronary artery disease remains the leading cause of death globally and is a major burden to every health system in the world. There have been significant…”
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Serum Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 (sLOX-1) Is Associated with Atherosclerosis Severity in Coronary Artery Disease by Kott, Katharine A, Genetzakis, Elijah, Gray, Michael P, Hansen, Peter, McGuire, Helen M, Yang, Jean Y, Grieve, Stuart M, Vernon, Stephen T, Figtree, Gemma A

“…Risk-factor-based scoring systems for atherosclerotic coronary artery disease (CAD) remain concerningly inaccurate at the level of the individual and would…”
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Lipidomics Profiling and Risk of Coronary Artery Disease in the BioHEART-CT Discovery Cohort by Zhu, Dantong, Vernon, Stephen T, D'Agostino, Zac, Wu, Jingqin, Giles, Corey, Chan, Adam S, Kott, Katharine A, Gray, Michael P, Gholipour, Alireza, Tang, Owen, Beyene, Habtamu B, Patrick, Ellis, Grieve, Stuart M, Meikle, Peter J, Figtree, Gemma A, Yang, Jean Y H

“…The current coronary artery disease (CAD) risk scores for predicting future cardiovascular events rely on well-recognized traditional cardiovascular risk…”
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The Translation and Commercialisation of Biomarkers for Cardiovascular Disease—A Review by Saleh, Soloman, George, Jacob, Kott, Katharine A., Meikle, Peter J., Figtree, Gemma A.

“…As a leading cause of mortality and morbidity worldwide, cardiovascular disease and its diagnosis, quantification, and stratification remain significant health…”
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Metabolic Signatures in Coronary Artery Disease: Results from the BioHEART-CT Study by Vernon, Stephen T, Tang, Owen, Kim, Taiyun, Chan, Adam S, Kott, Katharine A, Park, John, Hansen, Thomas, Koay, Yen C, Grieve, Stuart M, O'Sullivan, John F, Yang, Jean Y, Figtree, Gemma A

“…Despite effective prevention programs targeting cardiovascular risk factors, coronary artery disease (CAD) remains the leading cause of death. Novel biomarkers…”
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Biomarker Development in Cardiology: Reviewing the Past to Inform the Future by Kott, Katharine A, Bishop, Michael, Yang, Christina H J, Plasto, Toby M, Cheng, Daniel C, Kaplan, Adam I, Cullen, Louise, Celermajer, David S, Meikle, Peter J, Vernon, Stephen T, Figtree, Gemma A

“…Cardiac biomarkers have become pivotal to the clinical practice of cardiology, but there remains much to discover that could benefit cardiology patients. We…”
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Patient Endothelial Colony-Forming Cells to Model Coronary Artery Disease Susceptibility and Unravel the Role of Dysregulated Mitochondrial Redox Signalling by Besnier, Marie, Finemore, Meghan, Yu, Christine, Kott, Katharine A., Vernon, Stephen T., Seebacher, Nicole A., Genetzakis, Elijah, Furman, Anamarija, Tang, Owen, Davis, Ryan L., Hansen, Thomas, Psaltis, Peter J., Bubb, Kristen J., Wise, Steven G., Grieve, Stuart M., Di Bartolo, Belinda A., Figtree, Gemma A.

“…Mechanisms involved in the individual susceptibility to atherosclerotic coronary artery disease (CAD) beyond traditional risk factors are poorly understood…”
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Mass cytometry analysis reveals altered immune profiles in patients with coronary artery disease by Kott, Katharine A, Chan, Adam S, Vernon, Stephen T, Hansen, Thomas, Kim, Taiyun, de Dreu, Macha, Gunasegaran, Bavani, Murphy, Andrew J, Patrick, Ellis, Psaltis, Peter J, Grieve, Stuart M, Yang, Jean Y, Fazekas de St Groth, Barbara, McGuire, Helen M, Figtree, Gemma A

“…Abstract Objective The importance of inflammation in atherosclerosis is well accepted, but the role of the adaptive immune system is not yet fully understood…”
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Utilizing state‐of‐the‐art “omics” technology and bioinformatics to identify new biological mechanisms and biomarkers for coronary artery disease by Vernon, Stephen T., Hansen, Thomas, Kott, Katharine A., Yang, Jean Y., O'Sullivan, John F., Figtree, Gemma A.

“…Identification of the four standard modifiable cardiovascular risk factors (SMuRFs)—diabetes mellitus, hyperlipidaemia, hypertension, and cigarette smoking—has…”
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Immunoglobulin E Sensitization to Mammalian Oligosaccharide Galactose-α-1,3 (α-Gal) Is Associated With Noncalcified Plaque, Obstructive Coronary Artery Disease, and ST-Segment–Elevated Myocardial Infarction by Vernon, Stephen T., Kott, Katharine A., Hansen, Thomas, Finemore, Meghan, Baumgart, Karl W., Bhindi, Ravinay, Yang, Jean, Hansen, Peter S., Nicholls, Stephen J., Celermajer, David S., Ward, Michael R., van Nunen, Sheryl A., Grieve, Stuart M., Figtree, Gemma A.

“…Treating known risk factors for coronary artery disease (CAD) has substantially reduced CAD morbidity and mortality. However, a significant burden of CAD…”
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Coronary artery disease burden in women poorly explained by traditional risk factors: Sex disaggregated analyses from the BioHEART-CT study by Vernon, Stephen T., Kott, Katharine A., Hansen, Thomas, Zhang, Kimble J., Cole, Ben R., Coffey, Sean, Grieve, Stuart M., Figtree, Gemma A.

“…Targeting the modifiable risk factors for coronary artery disease (CAD) has substantial impact at the community level. However, it is not uncommon for…”
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Biobanking for discovery of novel cardiovascular biomarkers using imaging-quantified disease burden: protocol for the longitudinal, prospective, BioHEART-CT cohort study by Kott, Katharine A, Vernon, Stephen T, Hansen, Thomas, Yu, Christine, Bubb, Kristen J, Coffey, Sean, Sullivan, David, Yang, Jean, O'Sullivan, John, Chow, Clara, Patel, Sanjay, Chong, James, Celermajer, David S, Kritharides, Leonard, Grieve, Stuart M, Figtree, Gemma A

“…IntroductionCoronary artery disease (CAD) persists as a major cause of morbidity and mortality worldwide despite intensive identification and treatment of…”
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Association of Global Coagulation Profiles With Cardiovascular Risk Factors and Atherosclerosis: A Sex Disaggregated Analysis From the BioHEART-CT Study by Kott, Katharine A, Morel-Kopp, Marie-Christine, Vernon, Stephen T, Takagi, Yuki, Di Bartolo, Belinda A, Peter, Karlheinz, Yang, Jean Y, Grieve, Stuart M, Ward, Christopher, Figtree, Gemma A

“…Background Although the association between dysregulated coagulation and atherosclerosis is well recognized, individual assays have been of minimal value in…”
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Abstract 16324: The Overall Haemostatic Potential: A Novel Coagulation Measure Associated With Sex-specific Differences in Early Atherosclerosis and Metabolic Dysfunction by Kott, Katharine A, Morel-Kopp, Marie-Christine, Vernon, Stephen T, Takagi, Yuki, Ward, Christopher, Figtree, Gemma A

“…Introduction & AimPlaque micro-ruptures and associated thrombosis are a contributor to the progression of coronary artery disease (CAD). We sought to determine…”
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Immunoglobulin E Sensitization to Mammalian Oligosaccharide Galactose-a-1,3 (α-Gal) Is Associated With Noncalcified Plaque, Obstructive Coronary Artery Disease, and ST-Segment–Elevated Myocardial Infarction by Vernon, Stephen T., Kott, Katharine A., Hansen, Thomas, Finemore, Meghan, Baumgart, Karl W., Bhindi, Ravinay, Yang, Jean, Hansen, Peter S., Nicholls, Stephen J., Celermajer, David S., Ward, Michael R., van Nunen, Sheryl A., Grieve, Stuart M., Figtree, Gemma A.

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Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: JACC State-of-the-Art Review by Figtree, Gemma A, Vernon, Stephen T, Harmer, Jason A, Gray, Michael P, Arnott, Clare, Bachour, Eric, Barsha, Giannie, Brieger, David, Brown, Alex, Celermajer, David S, Channon, Keith M, Chew, Nicholas W S, Chong, James J H, Chow, Clara K, Cistulli, Peter A, Ellinor, Patrick T, Grieve, Stuart M, Guzik, Tomasz J, Hagström, Emil, Jenkins, Alicia, Jennings, Garry, Keech, Anthony C, Kott, Katharine A, Kritharides, Leonard, Mamas, Mamas A, Mehran, Roxana, Meikle, Peter J, Natarajan, Pradeep, Negishi, Kazuaki, O'Sullivan, John, Patel, Sanjay, Psaltis, Peter J, Redfern, Julie, Steg, Philippe G, Sullivan, David R, Sundström, Johan, Vogel, Birgit, Wilson, Andrew, Wong, Dennis, Bhatt, Deepak L, Kovacic, Jason C, Nicholls, Stephen J

“…Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery…”
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Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors: State-of-the-Art Review by Figtree, Gemma A., Vernon, Stephen T., Harmer, Jason A., Gray, Michael P., Arnott, Clare, Bachour, Eric, Barsha, Giannie, Brieger, David, Brown, Alex, Celermajer, David S., Channon, Keith M., Chew, Nicholas W.S., Chong, James J.H., Chow, Clara K., Cistulli, Peter A., Ellinor, Patrick T., Grieve, Stuart M., Guzik, Tomasz J., Hagström, Emil, Jenkins, Alicia, Jennings, Garry, Keech, Anthony C., Kott, Katharine A., Kritharides, Leonard, Mamas, Mamas A., Mehran, Roxana, Meikle, Peter J., Natarajan, Pradeep, Negishi, Kazuaki, O’Sullivan, John, Patel, Sanjay, Psaltis, Peter J., Redfern, Julie, Steg, Philippe G., Sullivan, David R., Sundström, Johan, Vogel, Birgit, Wilson, Andrew, Wong, Dennis, Bhatt, Deepak L., Kovacic, Jason C., Nicholls, Stephen J.

“…Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery…”
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Clinical Pathway for Coronary Atherosclerosis in Patients Without Conventional Modifiable Risk Factors by Figtree, Gemma A., Vernon, Stephen T., Harmer, Jason A., Gray, Michael P., Arnott, Clare, Bachour, Eric, Barsha, Giannie, Brieger, David, Brown, Alex, Celermajer, David S., Channon, Keith M., Chew, Nicholas W.S., Chong, James J.H., Chow, Clara K., Cistulli, Peter A., Ellinor, Patrick T., Grieve, Stuart M., Guzik, Tomasz J., Hagström, Emil, Jenkins, Alicia, Jennings, Garry, Keech, Anthony C., Kott, Katharine A., Kritharides, Leonard, Mamas, Mamas A., Mehran, Roxana, Meikle, Peter J., Natarajan, Pradeep, Negishi, Kazuaki, O’Sullivan, John, Patel, Sanjay, Psaltis, Peter J., Redfern, Julie, Steg, Philippe G., Sullivan, David R., Sundström, Johan, Vogel, Birgit, Wilson, Andrew, Wong, Dennis, Bhatt, Deepak L., Kovacic, Jason C., Nicholls, Stephen J., Ademi, Zanfina, Avis, Suzanne Robyn, Chan, Adam, Contreras, Osvaldo, Coorey, Craig P., Fathieh, Sina, Genetzakis, Elijah, Gholipour, Alireza, Giles, Corey, Hollings, Matthew, Hyun, Karice, Kazi, Samia, Kovacic, Jason C., Larance, Mark, Marathe, Jessica A., Marquina, Clara, Nelson, Adam, Ng, Hooi Hooi, Patrick, Ellis, Peter, Karlheinz, Tran, Andy, Yang, Jean, Zhu, Dantong, Zwack, Clara

“…Reducing the incidence and prevalence of standard modifiable cardiovascular risk factors (SMuRFs) is critical to tackling the global burden of coronary artery…”
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