Bone Tissue Condition during Osteosynthesis of a Femoral Shaft Fracture Using Biodegradable Magnesium Implants with an Anticorrosive Coating in Rats with Experimental Osteoporosis

Bone Tissue Condition during Osteosynthesis of a Femoral Shaft Fracture Using Biodegradable Magnesium Implants with an Anticorrosive Coating in Rats with Experimental Osteoporosis

Today, osteoporosis has become a major global health issues. The World Health Organization declares that 320 billion people have osteoporosis now, and more than 1.5 billion osteoporosis traumatic events occur every year. Bones become fragile and fracture risk is high; thus, it is crucial to choose t...

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Bibliographic Details
Published in:Applied sciences Vol. 12; no. 9; p. 4617
Main Authors: Maistrovskaia, Yuliya V., Nevzorova, Vera A., Ugay, Liyudmila G., Gnedenkov, Sergey V., Kotsurbei, Evgeny A., Moltyh, Ekaterina A., Kostiv, Roman E., Sinebryukhov, Sergey L.
Format: Journal Article
Language:English
Published: Basel MDPI AG 01-05-2022
Subjects:
Angiogenesis
Biocompatibility
Biodegradability
biodegradable implants
Biodegradable materials
Biodegradation
Biomedical materials
Bone density
Bone growth
Bones
Coatings
Corrosion
Corrosion prevention
Femur
Fractures
Global health
Hydroxyapatite
Laboratory animals
Magnesium
Magnesium alloys
Medical research
Metabolism
Orthopaedic implants
Osteogenesis
Osteoporosis
Osteosynthesis
Patients
polytetrafluoroethylene
Protective coatings
Public health
Surgical implants
Transplants & implants
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Summary:Today, osteoporosis has become a major global health issues. The World Health Organization declares that 320 billion people have osteoporosis now, and more than 1.5 billion osteoporosis traumatic events occur every year. Bones become fragile and fracture risk is high; thus, it is crucial to choose the right biodegradable implants in order to minimize reoperations of patients with systemic osteoporosis. This investigation aimed to carry out a morphological assessment of the state of bone tissue with osteosynthesis of a femoral fracture in rats, using a model of osteoporosis with the installation of magnesium alloy implants coated with hydroxyapatite and sealed with polytetrafluoroethylene. According to this study, the indicators of angiogenesis and bone formation in experimental animals were significantly higher when an implant coated with hydroxyapatite sealed with polytetrafluoroethylene was used, compared to an implant coated only with hydroxyapatite and in rats without an implant. Based on the data obtained, it is possible to consider a magnesium implant coated with hydroxyapatite and sealed with polytetrafluoroethylene as a promising material for fracture therapy in patients with reduced bone density.
ISSN:2076-3417
2076-3417
DOI:10.3390/app12094617