Search Results - "Kotsinas, A."

The DNA damage checkpoint precedes activation of ARF in response to escalating oncogenic stress during tumorigenesis by Evangelou, K, Bartkova, J, Kotsinas, A, Pateras, I S, Liontos, M, Velimezi, G, Kosar, M, Liloglou, T, Trougakos, I P, Dyrskjot, L, Andersen, C L, Papaioannou, M, Drosos, Y, Papafotiou, G, Hodny, Z, Sosa-Pineda, B, Wu, X-R, Klinakis, A, Ørntoft, T, Lukas, J, Bartek, J, Gorgoulis, V G

“…Oncogenic stimuli trigger the DNA damage response (DDR) and induction of the alternative reading frame (ARF) tumor suppressor, both of which can activate the…”
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Oncogene-induced replication stress preferentially targets common fragile sites in preneoplastic lesions. A genome-wide study by Tsantoulis, P K, Kotsinas, A, Sfikakis, P P, Evangelou, K, Sideridou, M, Levy, B, Mo, L, Kittas, C, Wu, X-R, Papavassiliou, A G, Gorgoulis, V G

“…Common fragile sites (CFSs) are regions of the genome prone to breakage by replication inhibitors (extrinsic replication stress). Recently, we and others…”
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Gene amplification is a relatively frequent event leading to ZBTB7A (Pokemon) overexpression in non-small cell lung cancer by Apostolopoulou, K, Pateras, IS, Evangelou, K, Tsantoulis, PK, Liontos, M, Kittas, C, Tiniakos, DG, Kotsinas, A, Cordon-Cardo, C, Gorgoulis, VG

“…ZBTB7A (Pokemon) is a member of the POK family of transcriptional repressors. Its main function is the suppression of the p14ARF tumour suppressor gene…”
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E2F-1 overexpression correlates with decreased proliferation and better prognosis in adenocarcinomas of Barrett oesophagus by Evangelou, K, Kotsinas, A, Mariolis-Sapsakos, T, Giannopoulos, A, Tsantoulis, P K, Constantinides, C, Troupis, T G, Salmas, M, Kyroudis, A, Kittas, C, Gorgoulis, V G

“…E2F-1 expression is positively associated with tumour growth in oesophageal squamous-cell carcinomas (OSCC), while it exhibits oncosuppressive features in…”
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Why is p53-inducible gene 3 rarely affected in cancer? by Kotsinas, A, Pateras, I S, Galanos, P S, Karamouzis, M V, Sfikakis, P P, Gorgoulis, V G

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Heregulin, Cysteine Rich-61 and Matrix Metalloproteinase 9 Expression in Human Carotid Atherosclerotic Plaques: Relationship with Clinical Data by Sigala, F., Georgopoulos, S., Papalambros, E., Chasiotis, D., Vourliotakis, G., Niforou, A., Kotsinas, A., Kavantzas, N., Patsouris, E., Gorgoulis, V.G., Bastounis, E.

“…Heregulins (HRGs) are known to induce expression of angiogenic factors such as cysteine rich-61 (CYR61) and collectively to promote neoangiogenesis. Along with…”
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Relationship between iNOS expression and aortic cell proliferation and apoptosis in an elastase-induced model of aorta aneurysm and the effect of 1400 W administration by Sigala, F., Papalambros, E., Kotsinas, A., Andreadou, I., Sigalas, P., Kremastinos, D., Bastounis, E., Gorgoulis, V.G.

“…In the present study, we employed an elastase infusion–dependent abdominal aortic aneurysm (AAA) model to examine inducible nitric oxide synthase (iNOS)…”
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Absence of association with cancer risk and low frequency of alterations at a p53 responsive PIG3 gene polymorphism in breast and lung carcinomas by Gorgoulis, V G, Liloglou, T, Sigala, F, Korkolis, D, Yannoukakos, D, Papalambros, E, Asimacopoulos, P J, Papavassiliou, A G, Kotsinas, A

“…The mechanisms of p53-dependent apoptosis involve a set of genes that possess the ability to modulate oxidative stress. One of them PIG3, is induced by p53…”
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9052 Single-nucleotide polymorphism K469E G>A in ICAM-1 gene in non-small cell lung cancer by Thanopoulou, E, Kotzamanis, G, Evangelou, K, Tomos, P, Dosios, T, Kotsinas, A, Gorgoulis, V.G

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A Deep Learning Framework for Predicting Response to Therapy in Cancer by Sakellaropoulos, Theodore, Vougas, Konstantinos, Narang, Sonali, Koinis, Filippos, Kotsinas, Athanassios, Polyzos, Alexander, Moss, Tyler J., Piha-Paul, Sarina, Zhou, Hua, Kardala, Eleni, Damianidou, Eleni, Alexopoulos, Leonidas G., Aifantis, Iannis, Townsend, Paul A., Panayiotidis, Mihalis I., Sfikakis, Petros, Bartek, Jiri, Fitzgerald, Rebecca C., Thanos, Dimitris, Mills Shaw, Kenna R., Petty, Russell, Tsirigos, Aristotelis, Gorgoulis, Vassilis G.

“…A major challenge in cancer treatment is predicting clinical response to anti-cancer drugs on a personalized basis. Using a pharmacogenomics database of 1,001…”
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Robust, universal biomarker assay to detect senescent cells in biological specimens by Evangelou, Konstantinos, Lougiakis, Nikolaos, Rizou, Sophia V., Kotsinas, Athanassios, Kletsas, Dimitris, Muñoz‐Espín, Daniel, Kastrinakis, Nikolaos G, Pouli, Nicole, Marakos, Panagiotis, Townsend, Paul, Serrano, Manuel, Bartek, Jiri, Gorgoulis, Vassilis G.

“…Summary Cellular senescence contributes to organismal development, aging, and diverse pathologies, yet available assays to detect senescent cells remain…”
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Machine learning and data mining frameworks for predicting drug response in cancer: An overview and a novel in silico screening process based on association rule mining by Vougas, Konstantinos, Sakellaropoulos, Theodore, Kotsinas, Athanassios, Foukas, George-Romanos P., Ntargaras, Andreas, Koinis, Filippos, Polyzos, Alexander, Myrianthopoulos, Vassilios, Zhou, Hua, Narang, Sonali, Georgoulias, Vassilis, Alexopoulos, Leonidas, Aifantis, Iannis, Townsend, Paul A., Sfikakis, Petros, Fitzgerald, Rebecca, Thanos, Dimitris, Bartek, Jiri, Petty, Russell, Tsirigos, Aristotelis, Gorgoulis, Vassilis G.

“…A major challenge in cancer treatment is predicting the clinical response to anti-cancer drugs on a personalized basis. The success of such a task largely…”
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Altered expression of the cell cycle regulatory molecules pRb, p53 and MDM2 exert a synergetic effect on tumor growth and chromosomal instability in non-small cell lung carcinomas (NSCLCs) by Gorgoulis, V G, Zacharatos, P, Kotsinas, A, Mariatos, G, Liloglou, T, Vogiatzi, T, Foukas, P, Rassidakis, G, Garinis, G, Ioannides, T, Zoumpourlis, V, Bramis, J, Michail, P O, Asimacopoulos, P J, Field, J K, Kittas, C

“…Recent in vitro studies provide evidence that the cell cycle molecules pRb, p53 and MDM2 form a tightly regulated protein network. In this study, we examined…”
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A recurrent chromosomal inversion suffices for driving escape from oncogene-induced senescence via subTAD reorganization by Zampetidis, Christos P., Galanos, Panagiotis, Angelopoulou, Andriani, Zhu, Yajie, Polyzou, Aikaterini, Karamitros, Timokratis, Kotsinas, Athanassios, Lagopati, Nefeli, Mourkioti, Ioanna, Mirzazadeh, Reza, Polyzos, Alexandros, Garnerone, Silvano, Mizi, Athanasia, Gusmao, Eduardo G., Sofiadis, Konstantinos, Gál, Zita, Larsen, Dorthe H., Pefani, Dafni-Eleftheria, Demaria, Marco, Tsirigos, Aristotelis, Crosetto, Nicola, Maya-Mendoza, Apolinar, Papaspyropoulos, Angelos, Evangelou, Konstantinos, Bartek, Jiri, Papantonis, Argyris, Gorgoulis, Vassilis G.

“…Oncogene-induced senescence (OIS) is an inherent and important tumor suppressor mechanism. However, if not removed timely via immune surveillance, senescent…”
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Alterations of p16-pRb pathway and chromosome locus 9p21-22 in sporadic invasive breast carcinomas by Gorgoulis, V G, Koutroumbi, E N, Kotsinas, A, Zacharatos, P, Markopoulos, C, Giannikos, L, Kyriakou, V, Voulgaris, Z, Gogas, I, Kittas, C

“…The p16-pRb pathway represents a vital cell-cycle checkpoint. In the present study we investigated the alterations of this G1-phase protein pathway using…”
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Sensitive differential detection of genetically related mycobacterial pathogens in archival material by IKONOMOPOULOS, John A, GORGOULIS, Vassilis G, KASTRINAKIS, Nikos G, ZACHARATOS, Panayotis V, KOKOTAS, Stavros N, EVANGELOU, Kostas, KOTSINAS, Athanassios G, TSAKRIS, Athanassios G, MANOLIS, Evangelos N, KITTAS, Christos N

“…A polymerase chain reaction (PCR) assay targeted to the immunogenic protein MPB64 gene was used to detect members of the Mycobacterium tuberculosis complex,…”
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A fluorophore-conjugated reagent enabling rapid detection, isolation and live tracking of senescent cells by Magkouta, Sophia, Veroutis, Dimitris, Pousias, Athanasios, Papaspyropoulos, Angelos, Pippa, Natassa, Lougiakis, Nikolaos, Kambas, Konstantinos, Lagopati, Nefeli, Polyzou, Aikaterini, Georgiou, Maria, Chountoulesi, Maria, Pispas, Stergios, Foutadakis, Spyros, Pouli, Nicole, Marakos, Panagiotis, Kotsinas, Athanassios, Verginis, Panayotis, Valakos, Dimitrios, Mizi, Athanasia, Papantonis, Argyris, Vatsellas, Giannis, Galanos, Panagiotis, Bartek, Jiri, Petty, Russell, Serrano, Manuel, Thanos, Dimitris, Roussos, Charis, Demaria, Marco, Evangelou, Konstantinos, Gorgoulis, Vassilis G.

“…Cellular senescence is a stress-response mechanism implicated in various physiological processes, diseases, and aging. Current detection approaches have…”
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Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability by Galanos, Panagiotis, Pappas, George, Polyzos, Alexander, Kotsinas, Athanassios, Svolaki, Ioanna, Giakoumakis, Nickolaos N, Glytsou, Christina, Pateras, Ioannis S, Swain, Umakanta, Souliotis, Vassilis L, Georgakilas, Alexandros G, Geacintov, Nicholas, Scorrano, Luca, Lukas, Claudia, Lukas, Jiri, Livneh, Zvi, Lygerou, Zoi, Chowdhury, Dipanjan, Sørensen, Claus Storgaard, Bartek, Jiri, Gorgoulis, Vassilis G

“…Genomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic…”
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Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions by DiTullio, Richard A, Vassiliou, Leandros-Vassilios F, Karakaidos, Panagiotis, Kastrinakis, Nikolaos G, Halazonetis, Thanos D, Liloglou, Triantafillos, Yoneta, Akihiro, Kletsas, Dimitris, Kotsinas, Athanassios, Kittas, Christos, Zacharatos, Panayotis, Gorgoulis, Vassilis G, Herlyn, Meenhard, Venere, Monica, Levy, Brynn

“…DNA damage checkpoint genes, such as p53, are frequently mutated in human cancer, but the selective pressure for their inactivation remains elusive. We…”
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Low levels of p27 in association with deregulated p53-pRb protein status enhance tumor proliferation and chromosomal instability in non-small cell lung carcinomas by Tsoli, E, Gorgoulis, V G, Zacharatos, P, Kotsinas, A, Mariatos, G, Kastrinakis, N G, Kokotas, S, Kanavaros, P, Asimacopoulos, P, Bramis, J, Kletsas, D, Papavassiliou, A G, Kittas, C

“…Down-regulation or overexpression of the cyclin-dependent kinase inhibitor p27 have been observed in a range of malignancies, including lung cancer. To further…”
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