Search Results - "Kotovskaya, S K"

Inhibition of DNA gyrase by levofloxacin and related fluorine-containing heterocyclic compounds by Tunitskaya, V L, Khomutov, A R, Kochetkov, S N, Kotovskaya, S K, Charushin, V N

“…Fluoroquinolones are an important class of modern and efficient antibacterial drugs with a broad spectrum of activity. Levofloxacin (the optically active form…”
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5-Alkylamino-7-aminoazolo[1,5-a]pyrimidine-6-carbonitriles: synthetic strategies and anticancer activity in vitro by Urakov, G. V., Savateev, K. V., Melekhin, V. V., Kotovskaya, S. K., Rusinov, V. L.

“…The design of novel antagonists for adenosine A 2a receptor (A 2a AR) is a promising strategy for the development of new-generation anticancer agents…”
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Comparative Analysis of the Antiviral Activity of Various Drugs Based on 6-Fluoro-3-Hydroxy-2-Pyrazinecarboxamide (Favipiravir) Against COVID-19 by S. Ya. Loginova, V. N. Schukina, S. V. Savenko, V. V. Rubtsov, S. V. Borisevich, D. L. Chizhov, G. L. Rusinov, E. V. Verbitskiy, V. N. Charushin, S. K. Kotovskaya, V. L. Rusinov

“…Background. The COVID-19 pandemic, caused by the SARS-CoV-2 coronavirus, originated in Wuhan, China, has claimed millions of lives around the world. In this…”
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The Effects of Nitroazolopyrimidines on the A1 Adenosine Receptor and Intraocular Pressure in Rats by Savateev, K. V., Rusinov, V. L., Kotovskaya, S. K., Spasov, A. A., Naumenko, L. V., Taran, A. S., Brigadirova, A. A., Yakovlev, D. S., Sultanova, K. T., Shcherbakova, N. M.

“…Six compounds of the 5(7)-alkylamino-6-nitroazolopyrimidine and 8-alkylazolo[5,1- b ]purine series were selected based on the structural analysis of A 1…”
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Synthesis and antiviral activity of fluorinated pyrido[1,2-a]benzimidazoles by Kotovskaya, S. K., Baskakova, Z. M., Charushin, V. N., Chupakhin, O. N., Belanov, E. F., Bormotov, N. I., Balakhnin, S. M., Serova, O. A.

“…Methods for the synthesis of fluorinated pyrido[1,2-a]benzimidazoles have been developed, and a series of such compounds has been obtained and studied for…”
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Synthesis of pyridines from 1,2,4-triazines under high pressure by Krayushkin, M. M, Sedishev, I. P, Yarovenko, V. N, Zavarzin, I. V, Kotovskaya, S. K, Kozhevnikov, D. N, Charushin, V. N

“…A procedure has been proposed for the synthesis of pyridines from 1,2,4-triazine derivatives and bicyclo[2.2.1]hepta-2,5-diene under high pressure in the…”
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Synthesis and antiviral activity of fluorinated 3-phenyl-1,2,4-benzotriazines by Kotovskaya, S. K., Zhumabaeva, G. A., Perova, N. M., Baskakova, Z. M., Charushin, V. N., Chupakhin, O. N., Belanov, E. F., Bormotov, N. I., Balakhnin, S. M., Serova, O. A.

“…New synthetic approaches to fluorinated 3-phenyl-1,2,4-benzotriazines for biological testing have been elaborated. 1-(3,4-Difluorophenyl)-3,5-diphenylformazan…”
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Fluorinated derivatives of benz[4,5]imidazo[1,2-b][1,3] thiazole--inhibitors of reproduction of measles virus by Pokrovskii, A G, Il'icheva, T N, Kotovskaya, S K, Romanova, S A, Charushin, V N, Chupakhin, O N

“…(ProQuest: Abstract omitted; see image)[PUBLICATION ABSTRACT]…”
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Intramolecular Nucleophilic Substitution of Hydrogen in (Quinoxalinyl-2)aminovinyl Derivatives as a New Approach to Pyrrolo- and Indolo[2,3-b]quinoxalines by Kotovskaya, S. K., Charushin, V. N., Perova, N. M., Kodess, M. I., Chupakhin, O. N.

“…Pyrrolo[2,3-b]- and indolo[2,3-b]quinoxalines were obtained by the reaction of 2-aminoquinoxalines with ketones followed by the intramolecular displacement of…”
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Fluorine-containing Heterocycles: XI. 5(6)-Fluoro-6(5)-X-benzofuroxans: Synthesis, Tautomerism, and Transformations by Chupakhin, O. N., Kotovskaya, S. K., Romanova, S. A., Charushin, V. N.

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Fused polycyclic nitrogen-containing heterocycles 11. 4-Hydroxy-3,5-diphenyl-2-phenyliminothiazolidines as new key compounds in the synthesis of thiazolo[3,4-a]quinoxaline derivatives by Mamedov, V. A., Nurkhametova, I. Z., Kotovskaya, S. K., Gubaidullin, A. T., Levin, Ya. A., Litvinov, I. A., Charushin, V. N.

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Triazaverin Prophylactic Efficacy Against Influenza Virus A (H5N1) by S. YA. Loginova, S. V. Borisevich, B. A. Maksimov, V. P. Bondarev, S. K. Kotovskaya, V. L. Rusinov, V. N. Charushin, O. N. Chupakhin

“…The experimental study of the prophylactic efficacy of Triazaverin against the experimental form of the influenza virus A (H5N1) on albino mice intranasally…”
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Therapeutic Efficacy of Triazavirin, a Novel Russian Chemotherapeutic, Against Influenza Virus A (H5N1) by S. A. Loginova, S. V. Borisevich, V. A. Maksimov, V. P. Bondarev, S. K. Kotovskaya, V. L. Rusinov, V. N. Charushkin, O. N. Chupakhin

“…Therapeutic activity of Triazavirin against experimental influenza A was studied on albino mice intranazally infected with influenza virus…”
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METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD by A. V. Baklykov, A. A. Tumashov, S. K. Kotovskaya, E. N. Ulomskiy, G. L. Rusinov, V. L. Rusinov, D. S. Kopchuk, O. N. Chupakhin, V. N. Charushin

“…A procedure for the simantenous determination of aminotriazole, triazolopyrimidinone and nirotriazolopyrimidinone was developed using the HPLC method with UV…”
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SIMULTANEOUS DETERMINATION OF AMINOTRIAZOLE AND TRIAZOLOPYRIMIDINONE - SUBSTRATE AND INTERMEDIATE IN THE SYNTHESIS OF «TRIAZIDE» BY HPLC by A. V. Baklykov, A. A. Tumashov, S. K. Kotovskaya, E. N. Ulomskiy, G. L. Rusinov, V. L. Rusinov, O. N. Chupahin, V. N. Charushin

“…Method of simultaneous determination of aminotriazole and triazolopyrimidinone using HPLC with UV-detection was developed. For best chromatographic performance…”
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METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-a]PIRIMIDINIDE l-ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD by A. V. Baklykov, A. A. Tumashov, S. K. Kotovskaya, E. N. Ulomsky, G. L. Rusinov, V. L. Rusinov, G. A. Artem’ev, D. S. Kopchuk, V. N. Charushin

“…A procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV…”
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NEW ANTIVIRAL DRUG TRIAZID. RESULTS OF FIRST PHASE OF CLINICAL TRIAL by E. G. Deyeva, Yu. I. Shevchik, A. A. Shaldghan, K. A. Zagorodnikova, A. A. Tumashov, A. V. Baklykov, S. K. Kotovskaya, O. N. Chupahin, V. N. Charushin, V. L. Rusinov, D. S. Kopchuk

“…The paper contains а results of the study of the pharmacokinetics, tolerability and safety of a new influenza drug Triazide in several dose regimens conducted…”
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Pyrido[2,3- b]- and pyrimido[4,5- b]quinoxalines: the first fluorine-containing derivatives by Charushin, Valerii N., Kotovskaya, Svetlana K., Perova, Natalya M., Chupakhin, Oleg N.

“…Fluorinated derivatives of pyrido[2,3- b]- and pyrimido[4,5- b]quinoxalines 5–8 have been prepared through the condensation of 2-amino-3-cyano- and…”
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Synthesis of fluorine-containing quinoline-2,3-dicarboxylates from products of vicarious nucleophilic substitution of hydrogen in 3-fluoronitroarenes by Kotovskaya, S. K., Zhumabaeva, G. A., Charushin, V. N., Chupakhin, O. N.

“…The reactions of 3-fluoro-4-R-6-phenylsulfonylmethylnitrobenzenes with dimethyl fumarate or diethyl maleate in acetonitrile in the presence of an excess of K 2…”
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Synthesis and reactivity of monothiooxamides of the aminonitroarene series by Yarovenko, V. N., Polushina, A. V., Levchenko, K. S., Zavarzin, I. V., Krayushkin, M. M., Kotovskaya, S. K., Charushin, V. N.

“…Monothiooxamides containing aminonitrobenzene and aminonitropyridine fragments have been synthesized. A possibility to synthesize thioesters and fused…”
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